ID   LHX9_BOVIN              Reviewed;         397 AA.
AC   A0JNI8; Q0V893;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=LIM/homeobox protein Lhx9;
DE            Short=LIM homeobox protein 9;
GN   Name=LHX9;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in gonadal development. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with LDB1 and LDB2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A0JNI8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A0JNI8-2; Sequence=VSP_036427;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BT026326; ABG81482.1; -; mRNA.
DR   EMBL; BC126704; AAI26705.1; -; mRNA.
DR   RefSeq; XP_010811854.1; XM_010813552.2. [A0JNI8-1]
DR   RefSeq; XP_015330757.1; XM_015475271.1. [A0JNI8-2]
DR   AlphaFoldDB; A0JNI8; -.
DR   BMRB; A0JNI8; -.
DR   SMR; A0JNI8; -.
DR   STRING; 9913.ENSBTAP00000041150; -.
DR   PaxDb; A0JNI8; -.
DR   GeneID; 515012; -.
DR   CTD; 56956; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; A0JNI8; -.
DR   OrthoDB; 1174930at2759; -.
DR   TreeFam; TF315442; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0097380; P:dorsal spinal cord interneuron anterior axon guidance; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Homeobox; LIM domain; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Zinc.
FT   CHAIN           1..397
FT                   /note="LIM/homeobox protein Lhx9"
FT                   /id="PRO_0000278839"
FT   DOMAIN          69..130
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          131..193
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DNA_BIND        267..326
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          248..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..18
FT                   /note="MEIVGCRAEDSSCPFRPP -> MLNGTTLEA (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_036427"
SQ   SEQUENCE   397 AA;  43889 MW;  C7BBF0DE784C6FBD CRC64;
     MEIVGCRAED SSCPFRPPAM LFHGISGGHI QGIMEEMERR SKSEARLAKG AQLNGRDAGM
     PPLSPEKPAL CAGCGGKIAD RYYLLAVDKQ WHLRCLKCCE CKLALESELT CFAKDGSIYC
     KEDYYRRFSV QRCARCHLGI SASEMVMRAR DSVYHLSCFT CSTCNKTLTT GDHFGMKDSL
     VYCRAHFETL LQGEYPPQLS YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV
     NYNSGCNENE ADHLDRDQQP YPPSQKTKRM RTSFKHHQLR TMKSYFAINH NPDAKDLKQL
     AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS GALSPPGTAT
     TLTDLTNPSI TVVTAVTSNM DSHESASPSQ TTLTNLF