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LHX9_CHICK
ID   LHX9_CHICK              Reviewed;         397 AA.
AC   Q90881;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=LIM/homeobox protein Lhx9;
DE            Short=LIM homeobox protein 9;
GN   Name=LHX9; Synonyms=LH-2A;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=9299541; DOI=10.1006/bbrc.1997.7320;
RA   Nohno T., Kawakami Y., Wada N., Ishikawa T., Ohuchi H., Noji S.;
RT   "Differential expression of the two closely related LIM-class homeobox
RT   genes LH-2A and LH-2B during limb development.";
RL   Biochem. Biophys. Res. Commun. 238:506-511(1997).
CC   -!- FUNCTION: May be involved in gonadal development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the limb mesenchyme throughout stages
CC       16 to 32. Expressed in the prospective wing bud at stage 16. Expressed
CC       in the leg bud at stage 17. Expressed in the forebrain throughout
CC       stages 14 to 21. {ECO:0000269|PubMed:9299541}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA50258.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L35566; AAA50258.1; ALT_INIT; mRNA.
DR   PIR; JC5658; JC5658.
DR   RefSeq; NP_990757.1; NM_205426.1.
DR   AlphaFoldDB; Q90881; -.
DR   SMR; Q90881; -.
DR   STRING; 9031.ENSGALP00000003475; -.
DR   PaxDb; Q90881; -.
DR   GeneID; 396397; -.
DR   KEGG; gga:396397; -.
DR   CTD; 56956; -.
DR   VEuPathDB; HostDB:geneid_396397; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; Q90881; -.
DR   OrthoDB; 1174930at2759; -.
DR   PhylomeDB; Q90881; -.
DR   PRO; PR:Q90881; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0097380; P:dorsal spinal cord interneuron anterior axon guidance; IDA:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021522; P:spinal cord motor neuron differentiation; IEP:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Zinc.
FT   CHAIN           1..397
FT                   /note="LIM/homeobox protein Lhx9"
FT                   /id="PRO_0000364229"
FT   DOMAIN          69..130
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          131..193
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DNA_BIND        267..326
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          40..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          378..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   397 AA;  44109 MW;  8C124654B394C43B CRC64;
     MEIVGCRAEE NTCPFRPPAM LFHGISGGHI QGIMEEMERR SKTESRLAKG GQMNGRETNM
     PPMSPEKPAL CAGCGGKISD RYYLLAVDKQ WHLRCLKCCE CKLALESELT CFAKDGSIYC
     KEDYYRRFSV QRCARCHLGI SASEMVMRAR ESVYHLSCFT CTTCNKTLTT GDHFGMKDNL
     VYCRAHFESL LQGEYPPQLS YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV
     NYNSGCNENE ADHMDRDQQP YPPSQKTKRM ATSFKHHQLR TMKSYFAINH NPDAKDLKQL
     AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS GALTPPGTAT
     TLTDLTNPTI TVVTSVTSNL DSHEPGSPSQ TTLTNLF
 
 
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