LHX9_CHICK
ID LHX9_CHICK Reviewed; 397 AA.
AC Q90881;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=LIM/homeobox protein Lhx9;
DE Short=LIM homeobox protein 9;
GN Name=LHX9; Synonyms=LH-2A;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9299541; DOI=10.1006/bbrc.1997.7320;
RA Nohno T., Kawakami Y., Wada N., Ishikawa T., Ohuchi H., Noji S.;
RT "Differential expression of the two closely related LIM-class homeobox
RT genes LH-2A and LH-2B during limb development.";
RL Biochem. Biophys. Res. Commun. 238:506-511(1997).
CC -!- FUNCTION: May be involved in gonadal development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the limb mesenchyme throughout stages
CC 16 to 32. Expressed in the prospective wing bud at stage 16. Expressed
CC in the leg bud at stage 17. Expressed in the forebrain throughout
CC stages 14 to 21. {ECO:0000269|PubMed:9299541}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA50258.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L35566; AAA50258.1; ALT_INIT; mRNA.
DR PIR; JC5658; JC5658.
DR RefSeq; NP_990757.1; NM_205426.1.
DR AlphaFoldDB; Q90881; -.
DR SMR; Q90881; -.
DR STRING; 9031.ENSGALP00000003475; -.
DR PaxDb; Q90881; -.
DR GeneID; 396397; -.
DR KEGG; gga:396397; -.
DR CTD; 56956; -.
DR VEuPathDB; HostDB:geneid_396397; -.
DR eggNOG; KOG0490; Eukaryota.
DR InParanoid; Q90881; -.
DR OrthoDB; 1174930at2759; -.
DR PhylomeDB; Q90881; -.
DR PRO; PR:Q90881; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0097380; P:dorsal spinal cord interneuron anterior axon guidance; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IEP:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Zinc.
FT CHAIN 1..397
FT /note="LIM/homeobox protein Lhx9"
FT /id="PRO_0000364229"
FT DOMAIN 69..130
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 131..193
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 267..326
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 40..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 397 AA; 44109 MW; 8C124654B394C43B CRC64;
MEIVGCRAEE NTCPFRPPAM LFHGISGGHI QGIMEEMERR SKTESRLAKG GQMNGRETNM
PPMSPEKPAL CAGCGGKISD RYYLLAVDKQ WHLRCLKCCE CKLALESELT CFAKDGSIYC
KEDYYRRFSV QRCARCHLGI SASEMVMRAR ESVYHLSCFT CTTCNKTLTT GDHFGMKDNL
VYCRAHFESL LQGEYPPQLS YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV
NYNSGCNENE ADHMDRDQQP YPPSQKTKRM ATSFKHHQLR TMKSYFAINH NPDAKDLKQL
AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS GALTPPGTAT
TLTDLTNPTI TVVTSVTSNL DSHEPGSPSQ TTLTNLF