LHX9_GLARU
ID LHX9_GLARU Reviewed; 379 AA.
AC A2PZF9; A2PZG0; A2PZG1; A2PZG2; A2PZG3;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=LIM/homeobox protein Lhx9;
DE Short=LIM homeobox protein 9;
GN Name=lhx9;
OS Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Glandirana.
OX NCBI_TaxID=8410;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RX PubMed=18217486; DOI=10.2108/zsj.24.798;
RA Oshima Y., Noguchi K., Nakamura M.;
RT "Expression of Lhx9 isoforms in the developing gonads of Rana rugosa.";
RL Zool. Sci. 24:798-802(2007).
CC -!- FUNCTION: May be involved in gonadal development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=A2PZF9-1; Sequence=Displayed;
CC Name=2; Synonyms=Beta;
CC IsoId=A2PZF9-2; Sequence=VSP_036433;
CC Name=3; Synonyms=Alpha;
CC IsoId=A2PZF9-3; Sequence=VSP_036434;
CC Name=4; Synonyms=Gamma;
CC IsoId=A2PZF9-4; Sequence=VSP_036435;
CC Name=5; Synonyms=Delta;
CC IsoId=A2PZF9-5; Sequence=VSP_036436;
CC -!- TISSUE SPECIFICITY: Isoform 1 and isoform 3 are expressed in ovary,
CC testis, brain and heart. Isoform 4 and isoform 5 are expressed in
CC brain. {ECO:0000269|PubMed:18217486}.
CC -!- DEVELOPMENTAL STAGE: Isoform 1, isoform 3, isoform 4 and isoform 5 are
CC expressed in the gonad/mesonephros complex at stage 25. Isoform 1 is
CC expressed in somatic cells of the gonad mesonephros and somites of a
CC tadpole at stage 25. {ECO:0000269|PubMed:18217486}.
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DR EMBL; AB269882; BAF46216.1; -; mRNA.
DR EMBL; AB269883; BAF46217.1; -; mRNA.
DR EMBL; AB269884; BAF46218.1; -; mRNA.
DR EMBL; AB269885; BAF46219.1; -; mRNA.
DR EMBL; AB269886; BAF46220.1; -; mRNA.
DR AlphaFoldDB; A2PZF9; -.
DR SMR; A2PZF9; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0097380; P:dorsal spinal cord interneuron anterior axon guidance; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Homeobox; LIM domain; Metal-binding;
KW Nucleus; Repeat; Zinc.
FT CHAIN 1..379
FT /note="LIM/homeobox protein Lhx9"
FT /id="PRO_0000364232"
FT DOMAIN 51..112
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 113..175
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 249..308
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 232..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 295..379
FT /note="VWFQNARAKFRRNLLRQENGGGDKVEGPSLSAPASTDSAALTPTGAASTLSD
FT LTSPSLNVGASVTPNMDSHESGSPSQTTLTNLF -> EVCYWPDDQVKTEGKKLKKRKL
FT MQPPHLMIGLVSKRTGEIQKESFTTGEWGRR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:18217486"
FT /id="VSP_036433"
FT VAR_SEQ 295..379
FT /note="VWFQNARAKFRRNLLRQENGGGDKVEGPSLSAPASTDSAALTPTGAASTLSD
FT LTSPSLNVGASVTPNMDSHESGSPSQTTLTNLF -> GEQCSGFNSHTTRRLKIP (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:18217486"
FT /id="VSP_036434"
FT VAR_SEQ 295..379
FT /note="VWFQNARAKFRRNLLRQENGGGDKVEGPSLSAPASTDSAALTPTGAASTLSD
FT LTSPSLNVGASVTPNMDSHESGSPSQTTLTNLF -> EVCYWPDDQVKTEGKKSKKRKL
FT MQPPHLMIGRTMFGV (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:18217486"
FT /id="VSP_036435"
FT VAR_SEQ 295..379
FT /note="VWFQNARAKFRRNLLRQENGGGDKVEGPSLSAPASTDSAALTPTGAASTLSD
FT LTSPSLNVGASVTPNMDSHESGSPSQTTLTNLF -> NVS (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:18217486"
FT /id="VSP_036436"
FT CONFLICT 264
FT /note="T -> M (in Ref. 1; BAF46218)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="K -> R (in Ref. 1; BAF46218)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="G -> R (in Ref. 1; BAF46220)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 379 AA; 42078 MW; 37BB060A84665DA1 CRC64;
MLFHGITGGH IQGIMEEMER RSKSADNRLA KTIQVNGRET RMPPLSPEKP TLCAGCGGKI
SDRYYLLAVD KQWHLRCLKC CECKLALESE LTCFAKDGSI YCKEDYYRRF SVQRCARCHL
GISASEIVMR ARESVYHLSC FTCTTCNKTL STGDHFGMKE NLVYRRAHFE LLVQGDFHSQ
LNYTELSAKG GGLSALPYFT NGTGAVQKGR PRKRKSPALG VDIINYTSGC NENDTDLDRD
QSYPPSQKTK RMRTSFKHHQ LRTTKSYFAI NHNPDAKDLK QLAQKTGLTK RVLQVWFQNA
RAKFRRNLLR QENGGGDKVE GPSLSAPAST DSAALTPTGA ASTLSDLTSP SLNVGASVTP
NMDSHESGSP SQTTLTNLF
