LHX9_RAT
ID LHX9_RAT Reviewed; 388 AA.
AC Q80W90; A1A5M2; Q811Z4;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=LIM/homeobox protein Lhx9;
DE Short=LIM homeobox protein 9;
GN Name=Lhx9;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Shan Y.X., Pan J., Geng D.C., Gu M.Y., Yu L.;
RT "Cloning and characterization of Rat LIM-homeodomain type transcription
RT factor Lhx9.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 23-347 (ISOFORM 1), AND DEVELOPMENTAL STAGE.
RC STRAIN=Wistar;
RX PubMed=12617828; DOI=10.1016/s1567-133x(02)00050-9;
RA Mazaud S., Oreal E., Guigon C.J., Carre-Eusebe D., Magre S.;
RT "Lhx9 expression during gonadal morphogenesis as related to the state of
RT cell differentiation.";
RL Gene Expr. Patterns 2:373-377(2002).
CC -!- FUNCTION: Involved in gonadal development. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with LDB1 and LDB2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80W90-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80W90-2; Sequence=VSP_036432;
CC -!- DEVELOPMENTAL STAGE: Expressed in the proliferating cells of the
CC coelomic epithelium of male and female gonads at 12 dpc. In female,
CC expressed in the whole gonadal primordium at 13.5 dpc; in the surface
CC epithelium and in the ovigerous cords at 15.5 dpc. In male, expressed
CC at surface cells of the gonads at 13.5 dpc; in mesenchymal cells
CC outside testicular cords at 18.5 dpc. {ECO:0000269|PubMed:12617828}.
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DR EMBL; AY273890; AAP32472.1; -; mRNA.
DR EMBL; BC128722; AAI28723.1; -; mRNA.
DR EMBL; AF527619; AAO27570.1; -; mRNA.
DR RefSeq; NP_852032.1; NM_181367.2. [Q80W90-1]
DR RefSeq; XP_006249978.1; XM_006249916.2. [Q80W90-1]
DR RefSeq; XP_006249981.1; XM_006249919.3. [Q80W90-2]
DR AlphaFoldDB; Q80W90; -.
DR SMR; Q80W90; -.
DR STRING; 10116.ENSRNOP00000013873; -.
DR PhosphoSitePlus; Q80W90; -.
DR PaxDb; Q80W90; -.
DR Ensembl; ENSRNOT00000014218; ENSRNOP00000014218; ENSRNOG00000010357. [Q80W90-2]
DR Ensembl; ENSRNOT00000101843; ENSRNOP00000092128; ENSRNOG00000010357. [Q80W90-1]
DR GeneID; 289048; -.
DR KEGG; rno:289048; -.
DR UCSC; RGD:727956; rat. [Q80W90-1]
DR CTD; 56956; -.
DR RGD; 727956; Lhx9.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000158821; -.
DR HOGENOM; CLU_027802_4_1_1; -.
DR InParanoid; Q80W90; -.
DR OMA; MQINGRE; -.
DR OrthoDB; 1174930at2759; -.
DR PhylomeDB; Q80W90; -.
DR TreeFam; TF315442; -.
DR PRO; PR:Q80W90; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000010357; Expressed in ovary and 2 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0008283; P:cell population proliferation; ISO:RGD.
DR GO; GO:0097380; P:dorsal spinal cord interneuron anterior axon guidance; ISS:UniProtKB.
DR GO; GO:0008585; P:female gonad development; ISO:RGD.
DR GO; GO:0035262; P:gonad morphogenesis; ISO:RGD.
DR GO; GO:0008584; P:male gonad development; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Homeobox; LIM domain; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Zinc.
FT CHAIN 1..388
FT /note="LIM/homeobox protein Lhx9"
FT /id="PRO_0000364228"
FT DOMAIN 69..130
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 131..193
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 267..326
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 239..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 304..388
FT /note="VWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALTPPGTATTLTD
FT LTNPTVTVVTTVTSNMDSHESGSPSQTTLTNLF -> GEQILGHYSQTSRRLKIP (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_036432"
SQ SEQUENCE 388 AA; 42934 MW; EFB0E5B612A3729C CRC64;
MLNGTTLEAA MLFHGISGGH IQGIMEEMER RSKTEARLAK GTQLNGRDAG MPPLSPEKPA
LCAGCGGKIS DRYYLLAVDK QWHLRCLKCC ECKLALESEL TCFAKDGSIY CKEDYYRRFS
VQRCARCHLG ISASEMVMRA RDSVYHLSCF TCSTCNKTLT TGDHFGMKDS LVYCRAHFET
LLQGEYPPQL SYTELAAKSG GLALPYFNGT GTVQKGRPRK RKSPALGVDI VNYNSGCNEN
EADHLDRDQQ PYPPSQKTKR MRTSFKHHQL RTMKSYFAIN HNPDAKDLKQ LAQKTGLTKR
VLQVWFQNAR AKFRRNLLRQ ENGGVDKADG TSLPAPPSAD SGALTPPGTA TTLTDLTNPT
VTVVTTVTSN MDSHESGSPS QTTLTNLF
