LHY_PETHY
ID LHY_PETHY Reviewed; 770 AA.
AC A0A0G3VTN5;
DT 02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT 16-SEP-2015, sequence version 1.
DT 25-MAY-2022, entry version 26.
DE RecName: Full=Protein LATE ELONGATED HYPOCOTYL {ECO:0000303|PubMed:26124104};
DE Short=PhLHY {ECO:0000303|PubMed:26124104};
GN Name=LHY {ECO:0000303|PubMed:26124104};
OS Petunia hybrida (Petunia).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Petunioideae; Petunia.
OX NCBI_TaxID=4102;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
RX PubMed=26124104; DOI=10.1073/pnas.1422875112;
RA Fenske M.P., Hewett Hazelton K.D., Hempton A.K., Shim J.S., Yamamoto B.M.,
RA Riffell J.A., Imaizumi T.;
RT "Circadian clock gene LATE ELONGATED HYPOCOTYL directly regulates the
RT timing of floral scent emission in Petunia.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:9775-9780(2015).
CC -!- FUNCTION: Transcription repressor involved in the circadian clock
CC (PubMed:26124104). Binds to the promoter region of target genes to
CC repress their transcription (e.g. PRR5 and GI) (PubMed:26124104).
CC Regulates the timing of floral scent, by restricting the expression of
CC ODO1 and other floral volatile benzenoids and phenylpropanoids (FVBP)
CC pathway genes (e.g. EPSPS and IGS1) to the evening (PubMed:26124104).
CC This scent, mostly produced in the evening and night by the petals,
CC attracts the pollinators (e.g. the night-active hawkmoth pollinator
CC Manduca sexta) (PubMed:26124104). Binds to and repress ODO1 and FVBP
CC genes (e.g. EPSPS and IGS1) promoters via cis-regulatory evening
CC elements (PubMed:26124104). {ECO:0000269|PubMed:26124104}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q6R0H1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- INDUCTION: Circadian-regulation with peak levels occurring in the
CC morning. {ECO:0000269|PubMed:26124104}.
CC -!- DISRUPTION PHENOTYPE: Early production of scent at the end of the light
CC period, associated with an early peak expression during the day of
CC floral volatile benzenoids and phenylpropanoids (FVBP) pathway genes
CC responsible for volatile precursor synthesis (e.g. EOBI, EOBII, ODO1,
CC EPSPS, CM1, ADT, and PAL). {ECO:0000269|PubMed:26124104}.
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DR EMBL; KP017483; AKL88450.1; -; mRNA.
DR AlphaFoldDB; A0A0G3VTN5; -.
DR SMR; A0A0G3VTN5; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR GO; GO:0007623; P:circadian rhythm; IEP:UniProtKB.
DR GO; GO:0010597; P:green leaf volatile biosynthetic process; IMP:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0042752; P:regulation of circadian rhythm; IMP:UniProtKB.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 2: Evidence at transcript level;
KW Biological rhythms; DNA-binding; Nucleus; Phosphoprotein; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..770
FT /note="Protein LATE ELONGATED HYPOCOTYL"
FT /id="PRO_0000451489"
FT DOMAIN 19..73
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 46..69
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 89..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 6
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P92973"
SQ SEQUENCE 770 AA; 84243 MW; A86EAC76B79F0577 CRC64;
MDPYSSGEEL VVKTRKPYTI TKQRERWTEE EHNRFLEALK LYGRAWQRIE EHIGTKTAVQ
IRSHAQKFFT KLEKEALIKG VPISEALDIE IPPPRPKRKP SNPYPRKTSI AVPTSQVGTK
DGKLSTPFPS ICENRNLLDL EKEPIIESVG GNEKLSNVQE NQNKKNFSQG FTLFKEGASA
ASVSLGKSSQ TLAEPTDSCT LNESVSVSKG VINHDVANKS FPAVESKGHQ QLDILDAKQS
FQFDSSCNTS SVGKSCQSNE KWAQGEQKDQ PSQPDHFEEF SRNDMQVPHN YPRHVPVHIL
DGTLGANGAQ TTPDMFYHKS VSHQVGGLQG LSDMYTNPAS SATSEQHSNA ARSSIHQSFP
CFHPIFTPIR DPDDYRSFLQ LSSTFSSLVV SALLQNPAAH AAASFAASFW PYANMEAPVD
STGNNTASQI NSAPSMAAIA AATVAAATAW WAAHGLLPLC SPFHSSLTCV PTSATSMQVD
VCQPKEGKSE GREGTHNSPP HVQQPGPECS EALQEQHSAS KLPTSPSSDS GESEGRNLKN
GLTATDTEQG AAVTETHEPN AEKVRKQVDR SSCGSNTPSS SEVETDALEK DEKGKEEPEE
PNVNLLAGDA ANRRGRNCIS NSNDSWKEVS EEGRMAFQAL FSREVLPQSF SRSNYLKTKG
NIDFEKFQQK PDEQGPSGSQ LDLNDQASNI CSSHQAVEEN VQFLLGNKEG AEKCQPTMEL
GEIRLKARRT GFKPYKRCSL EAKDSRVANS SCQDEEKSCK RLRLEGEAST
