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LIAH_BACSU
ID   LIAH_BACSU              Reviewed;         225 AA.
AC   O32201;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Protein LiaH;
GN   Name=liaH; Synonyms=yvqH; OrderedLocusNames=BSU33120;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9639930; DOI=10.1099/00221287-144-6-1593;
RA   Wipat A., Brignell C.S., Guy J.B., Rose M., Emmerson P.T., Harwood C.R.;
RT   "The yvsA-yvqA (293 degrees - 289 degrees) region of the Bacillus subtilis
RT   chromosome containing genes involved in metal ion uptake and a putative
RT   sigma factor.";
RL   Microbiology 144:1593-1600(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   INDUCTION BY VANCOMYCIN.
RC   STRAIN=168 / CU1065;
RX   PubMed=12207695; DOI=10.1046/j.1365-2958.2002.03050.x;
RA   Cao M., Wang T., Ye R., Helmann J.D.;
RT   "Antibiotics that inhibit cell wall biosynthesis induce expression of the
RT   Bacillus subtilis sigma(W) and sigma(M) regulons.";
RL   Mol. Microbiol. 45:1267-1276(2002).
RN   [4]
RP   INDUCTION BY BACITRACIN.
RC   STRAIN=168 / CU1065;
RX   PubMed=14651641; DOI=10.1046/j.1365-2958.2003.03786.x;
RA   Mascher T., Margulis N.G., Wang T., Ye R.W., Helmann J.D.;
RT   "Cell wall stress responses in Bacillus subtilis: the regulatory network of
RT   the bacitracin stimulon.";
RL   Mol. Microbiol. 50:1591-1604(2003).
RN   [5]
RP   INDUCTION BY ANTIBIOTICS.
RX   PubMed=15273097; DOI=10.1128/aac.48.8.2888-2896.2004;
RA   Mascher T., Zimmer S.L., Smith T.-A., Helmann J.D.;
RT   "Antibiotic-inducible promoter regulated by the cell envelope stress-
RT   sensing two-component system LiaRS of Bacillus subtilis.";
RL   Antimicrob. Agents Chemother. 48:2888-2896(2004).
RN   [6]
RP   INDUCTION BY STRESS.
RX   PubMed=15856219; DOI=10.1007/s00253-005-1898-1;
RA   Hyyrylaeinen H.-L., Sarvas M., Kontinen V.P.;
RT   "Transcriptome analysis of the secretion stress response of Bacillus
RT   subtilis.";
RL   Appl. Microbiol. Biotechnol. 67:389-396(2005).
RN   [7]
RP   INDUCTION BY LL-37; PG-1 AND TRITON X-100.
RC   STRAIN=168;
RX   PubMed=15870467; DOI=10.1099/mic.0.27761-0;
RA   Pietiaeinen M., Gardemeister M., Mecklin M., Leskelae S., Sarvas M.,
RA   Kontinen V.P.;
RT   "Cationic antimicrobial peptides elicit a complex stress response in
RT   Bacillus subtilis that involves ECF-type sigma factors and two-component
RT   signal transduction systems.";
RL   Microbiology 151:1577-1592(2005).
CC   -!- INDUCTION: Induced, via the two-component regulatory system LiaS/LiaR,
CC       by antibiotics (vancomycin, bacitracin, nisin and ramoplanin), cationic
CC       antimicrobial peptides (human LL-37 and porcine PG-1), Triton X-100 and
CC       severe secretion stress. {ECO:0000269|PubMed:12207695,
CC       ECO:0000269|PubMed:14651641, ECO:0000269|PubMed:15273097,
CC       ECO:0000269|PubMed:15856219, ECO:0000269|PubMed:15870467}.
CC   -!- SIMILARITY: Belongs to the PspA/IM30 family. {ECO:0000305}.
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DR   EMBL; AJ223978; CAA11741.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15302.1; -; Genomic_DNA.
DR   PIR; A70046; A70046.
DR   RefSeq; NP_391192.1; NC_000964.3.
DR   RefSeq; WP_003243047.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; O32201; -.
DR   SMR; O32201; -.
DR   STRING; 224308.BSU33120; -.
DR   PaxDb; O32201; -.
DR   PRIDE; O32201; -.
DR   EnsemblBacteria; CAB15302; CAB15302; BSU_33120.
DR   GeneID; 938585; -.
DR   KEGG; bsu:BSU33120; -.
DR   PATRIC; fig|224308.179.peg.3590; -.
DR   eggNOG; COG1842; Bacteria.
DR   InParanoid; O32201; -.
DR   OMA; MIFRAKA; -.
DR   PhylomeDB; O32201; -.
DR   BioCyc; BSUB:BSU33120-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   InterPro; IPR007157; PspA_IM30.
DR   PANTHER; PTHR31088; PTHR31088; 1.
DR   Pfam; PF04012; PspA_IM30; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..225
FT                   /note="Protein LiaH"
FT                   /id="PRO_0000166295"
FT   COILED          58..151
FT                   /evidence="ECO:0000255"
FT   COILED          161..182
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   225 AA;  25698 MW;  9D4054676DA5F8F3 CRC64;
     MVLKRIRDMF VASVHEGLDK MENPKVMLNQ YVRDMESDIA KAKQTIVKQH TIAYQFKKKY
     EEAAEVAGKR KNQAQLAFDA GEEELAKKAL TEMKYLEGKA AEHKASYEQA NSQLADLKEQ
     LAALETKLQD VKDKKQALIA RANAAKAKEH MNTTFDKIDS ESAYREFLRI ENRIEEMEIR
     ANYSKSAEAG TELTRKEFAD DVEAEIEKMR TLSLQKSDQT KAANE
 
 
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