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LIAI_BACSU
ID   LIAI_BACSU              Reviewed;         126 AA.
AC   O32202;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Protein LiaI;
GN   Name=liaI; Synonyms=yvqI; OrderedLocusNames=BSU33130;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9639930; DOI=10.1099/00221287-144-6-1593;
RA   Wipat A., Brignell C.S., Guy J.B., Rose M., Emmerson P.T., Harwood C.R.;
RT   "The yvsA-yvqA (293 degrees - 289 degrees) region of the Bacillus subtilis
RT   chromosome containing genes involved in metal ion uptake and a putative
RT   sigma factor.";
RL   Microbiology 144:1593-1600(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   INDUCTION BY VANCOMYCIN.
RC   STRAIN=168 / CU1065;
RX   PubMed=12207695; DOI=10.1046/j.1365-2958.2002.03050.x;
RA   Cao M., Wang T., Ye R., Helmann J.D.;
RT   "Antibiotics that inhibit cell wall biosynthesis induce expression of the
RT   Bacillus subtilis sigma(W) and sigma(M) regulons.";
RL   Mol. Microbiol. 45:1267-1276(2002).
RN   [4]
RP   INDUCTION BY BACITRACIN.
RC   STRAIN=168 / CU1065;
RX   PubMed=14651641; DOI=10.1046/j.1365-2958.2003.03786.x;
RA   Mascher T., Margulis N.G., Wang T., Ye R.W., Helmann J.D.;
RT   "Cell wall stress responses in Bacillus subtilis: the regulatory network of
RT   the bacitracin stimulon.";
RL   Mol. Microbiol. 50:1591-1604(2003).
RN   [5]
RP   INDUCTION BY ANTIBIOTICS.
RX   PubMed=15273097; DOI=10.1128/aac.48.8.2888-2896.2004;
RA   Mascher T., Zimmer S.L., Smith T.-A., Helmann J.D.;
RT   "Antibiotic-inducible promoter regulated by the cell envelope stress-
RT   sensing two-component system LiaRS of Bacillus subtilis.";
RL   Antimicrob. Agents Chemother. 48:2888-2896(2004).
RN   [6]
RP   INDUCTION BY STRESS.
RX   PubMed=15856219; DOI=10.1007/s00253-005-1898-1;
RA   Hyyrylaeinen H.-L., Sarvas M., Kontinen V.P.;
RT   "Transcriptome analysis of the secretion stress response of Bacillus
RT   subtilis.";
RL   Appl. Microbiol. Biotechnol. 67:389-396(2005).
RN   [7]
RP   INDUCTION BY LL-37; PG-1 AND TRITON X-100.
RC   STRAIN=168;
RX   PubMed=15870467; DOI=10.1099/mic.0.27761-0;
RA   Pietiaeinen M., Gardemeister M., Mecklin M., Leskelae S., Sarvas M.,
RA   Kontinen V.P.;
RT   "Cationic antimicrobial peptides elicit a complex stress response in
RT   Bacillus subtilis that involves ECF-type sigma factors and two-component
RT   signal transduction systems.";
RL   Microbiology 151:1577-1592(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Induced, via the two-component regulatory system LiaS/LiaR,
CC       by antibiotics (vancomycin, bacitracin, nisin and ramoplanin), cationic
CC       antimicrobial peptides (human LL-37 and porcine PG-1), Triton X-100 and
CC       severe secretion stress. {ECO:0000269|PubMed:12207695,
CC       ECO:0000269|PubMed:14651641, ECO:0000269|PubMed:15273097,
CC       ECO:0000269|PubMed:15856219, ECO:0000269|PubMed:15870467}.
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DR   EMBL; AJ223978; CAA11740.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15303.1; -; Genomic_DNA.
DR   PIR; B70046; B70046.
DR   RefSeq; NP_391193.1; NC_000964.3.
DR   RefSeq; WP_003243447.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; O32202; -.
DR   STRING; 224308.BSU33130; -.
DR   PaxDb; O32202; -.
DR   PRIDE; O32202; -.
DR   EnsemblBacteria; CAB15303; CAB15303; BSU_33130.
DR   GeneID; 935958; -.
DR   KEGG; bsu:BSU33130; -.
DR   PATRIC; fig|224308.179.peg.3591; -.
DR   eggNOG; COG4758; Bacteria.
DR   OMA; FGWKMMK; -.
DR   BioCyc; BSUB:BSU33130-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..126
FT                   /note="Protein LiaI"
FT                   /id="PRO_0000084416"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   126 AA;  13381 MW;  B2604CAFDE55DEB2 CRC64;
     MKINKKTIGG FLLIVFGISV FFGGGSFGFI IPLAIGSLMT YAGIKRFAAG KTITGIIVGG
     IGAIMLICSL PFVVGIALAA AMVYYGWKLM KNGSADNGVS SFDPEPASAA YQSHFDDEWE
     EFLKKK
 
 
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