LIAT1_HUMAN
ID LIAT1_HUMAN Reviewed; 453 AA.
AC Q6ZQX7; A5D8T6; Q6NSI2; Q6PFW9;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein LIAT1 {ECO:0000305};
DE AltName: Full=Ligand of ATE1 protein {ECO:0000305};
GN Name=LIAT1 {ECO:0000305}; Synonyms=C17orf97 {ECO:0000312|HGNC:HGNC:33800};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLU-220.
RC TISSUE=Stomach;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 12-453 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE
RP MRNA] OF 21-453 (ISOFORM 4), AND VARIANTS LYS-56 AND GLU-220.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP DOMAIN.
RX PubMed=25369936; DOI=10.1073/pnas.1419587111;
RA Brower C.S., Rosen C.E., Jones R.H., Wadas B.C., Piatkov K.I.,
RA Varshavsky A.;
RT "Liat1, an arginyltransferase-binding protein whose evolution among
RT primates involved changes in the numbers of its 10-residue repeats.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:E4936-E4945(2014).
CC -!- FUNCTION: May be involved in ATE1-mediated N-terminal arginylation.
CC {ECO:0000250|UniProtKB:Q810M6}.
CC -!- SUBUNIT: Interacts with ATE1; it is not a substrate of LIAT1. Interacts
CC with JMJD6 and MRPS14 (By similarity). {ECO:0000250|UniProtKB:Q810M6}.
CC -!- INTERACTION:
CC Q6ZQX7-4; P68133: ACTA1; NbExp=3; IntAct=EBI-25830459, EBI-367510;
CC Q6ZQX7-4; P13637: ATP1A3; NbExp=3; IntAct=EBI-25830459, EBI-948169;
CC Q6ZQX7-4; P08684: CYP3A4; NbExp=3; IntAct=EBI-25830459, EBI-3928618;
CC Q6ZQX7-4; P03372: ESR1; NbExp=3; IntAct=EBI-25830459, EBI-78473;
CC Q6ZQX7-4; P10809: HSPD1; NbExp=3; IntAct=EBI-25830459, EBI-352528;
CC Q6ZQX7-4; P16284: PECAM1; NbExp=3; IntAct=EBI-25830459, EBI-716404;
CC Q6ZQX7-4; Q13393: PLD1; NbExp=3; IntAct=EBI-25830459, EBI-2827556;
CC Q6ZQX7-4; P05771-2: PRKCB; NbExp=3; IntAct=EBI-25830459, EBI-5774511;
CC Q6ZQX7-4; P20339: RAB5A; NbExp=3; IntAct=EBI-25830459, EBI-399437;
CC Q6ZQX7-4; P08670: VIM; NbExp=3; IntAct=EBI-25830459, EBI-353844;
CC Q6ZQX7-4; P04275-2: VWF; NbExp=3; IntAct=EBI-25830459, EBI-25896548;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q6ZQX7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZQX7-2; Sequence=VSP_034197, VSP_034198;
CC Name=3;
CC IsoId=Q6ZQX7-3; Sequence=VSP_034195;
CC Name=4;
CC IsoId=Q6ZQX7-4; Sequence=VSP_034196;
CC -!- DOMAIN: LIAT1 proteins of some primates, from macaques to humans,
CC contain tandem repeats of a 10-residue sequence, whereas LIAT1 proteins
CC of other mammals contain a single copy of this motif. Quantities of
CC these repeats are, in general, different in LIAT1 of different
CC primates. For example, there are 1, 4, 13, 13, 17, and 17 repeats in
CC the gibbon, gorilla, orangutan, bonobo, neanderthal, and human LIAT1,
CC respectively. {ECO:0000305|PubMed:25369936}.
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DR EMBL; AK128660; BAC87555.1; -; mRNA.
DR EMBL; AC141424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057385; AAH57385.1; -; mRNA.
DR EMBL; BC070116; AAH70116.2; -; mRNA.
DR EMBL; BC141806; AAI41807.1; -; mRNA.
DR CCDS; CCDS32519.2; -. [Q6ZQX7-4]
DR RefSeq; NP_001013694.4; NM_001013672.4. [Q6ZQX7-4]
DR AlphaFoldDB; Q6ZQX7; -.
DR BioGRID; 134634; 3.
DR IntAct; Q6ZQX7; 12.
DR MINT; Q6ZQX7; -.
DR STRING; 9606.ENSP00000353245; -.
DR iPTMnet; Q6ZQX7; -.
DR PhosphoSitePlus; Q6ZQX7; -.
DR BioMuta; C17orf97; -.
DR DMDM; 327478504; -.
DR EPD; Q6ZQX7; -.
DR MassIVE; Q6ZQX7; -.
DR MaxQB; Q6ZQX7; -.
DR PeptideAtlas; Q6ZQX7; -.
DR PRIDE; Q6ZQX7; -.
DR ProteomicsDB; 68096; -. [Q6ZQX7-1]
DR ProteomicsDB; 68097; -. [Q6ZQX7-2]
DR ProteomicsDB; 68098; -. [Q6ZQX7-3]
DR ProteomicsDB; 68099; -. [Q6ZQX7-4]
DR Antibodypedia; 10251; 46 antibodies from 12 providers.
DR DNASU; 400566; -.
DR Ensembl; ENST00000360127.7; ENSP00000353245.6; ENSG00000187624.9. [Q6ZQX7-4]
DR Ensembl; ENST00000639297.2; ENSP00000491943.1; ENSG00000283985.2. [Q6ZQX7-4]
DR GeneID; 400566; -.
DR KEGG; hsa:400566; -.
DR MANE-Select; ENST00000360127.7; ENSP00000353245.6; NM_001013672.5; NP_001013694.4. [Q6ZQX7-4]
DR UCSC; uc021tna.1; human. [Q6ZQX7-1]
DR CTD; 400566; -.
DR DisGeNET; 400566; -.
DR GeneCards; C17orf97; -.
DR HGNC; HGNC:33800; C17orf97.
DR HPA; ENSG00000187624; Tissue enriched (testis).
DR neXtProt; NX_Q6ZQX7; -.
DR OpenTargets; ENSG00000187624; -.
DR PharmGKB; PA162378582; -.
DR VEuPathDB; HostDB:ENSG00000187624; -.
DR eggNOG; ENOG502SC86; Eukaryota.
DR GeneTree; ENSGT00440000038370; -.
DR HOGENOM; CLU_049741_0_0_1; -.
DR InParanoid; Q6ZQX7; -.
DR OMA; LKGFHTD; -.
DR PhylomeDB; Q6ZQX7; -.
DR TreeFam; TF337007; -.
DR PathwayCommons; Q6ZQX7; -.
DR SignaLink; Q6ZQX7; -.
DR BioGRID-ORCS; 400566; 14 hits in 1042 CRISPR screens.
DR GenomeRNAi; 400566; -.
DR Pharos; Q6ZQX7; Tdark.
DR PRO; PR:Q6ZQX7; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6ZQX7; protein.
DR Bgee; ENSG00000187624; Expressed in left testis and 98 other tissues.
DR ExpressionAtlas; Q6ZQX7; baseline and differential.
DR Genevisible; Q6ZQX7; HS.
DR GO; GO:0016598; P:protein arginylation; ISS:UniProtKB.
DR InterPro; IPR038794; LIAT1.
DR PANTHER; PTHR36474; PTHR36474; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..453
FT /note="Protein LIAT1"
FT /id="PRO_0000340233"
FT REPEAT 201..210
FT /note="1"
FT REPEAT 211..220
FT /note="2"
FT REPEAT 221..230
FT /note="3"
FT REPEAT 231..240
FT /note="4"
FT REPEAT 241..250
FT /note="5"
FT REPEAT 251..260
FT /note="6"
FT REPEAT 261..270
FT /note="7"
FT REPEAT 271..280
FT /note="8"
FT REPEAT 281..290
FT /note="9"
FT REPEAT 291..300
FT /note="10"
FT REPEAT 301..310
FT /note="11"
FT REPEAT 311..320
FT /note="12"
FT REPEAT 321..330
FT /note="13"
FT REPEAT 331..340
FT /note="14"
FT REPEAT 341..350
FT /note="15"
FT REPEAT 351..360
FT /note="16"
FT REPEAT 361..370
FT /note="17"
FT REPEAT 371..380
FT /note="18"
FT REPEAT 381..390
FT /note="19"
FT REPEAT 391..400
FT /note="20"
FT REGION 1..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..197
FT /note="Interaction with ATE1"
FT /evidence="ECO:0000250|UniProtKB:Q810M6"
FT REGION 201..400
FT /note="20 X 10 AA approximate tandem repeat of A-L-K-G-F-H-
FT P-D-P-E"
FT REGION 225..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..97
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 201..220
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034195"
FT VAR_SEQ 236..265
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034196"
FT VAR_SEQ 256..265
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034197"
FT VAR_SEQ 348..367
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034198"
FT VARIANT 56
FT /note="E -> K (in dbSNP:rs4581766)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_044008"
FT VARIANT 220
FT /note="D -> E (in dbSNP:rs35229416)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_044009"
FT CONFLICT 105
FT /note="Q -> L (in Ref. 3; AAI41807)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="L -> P (in Ref. 3; AAH57385)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="E -> D (in Ref. 3; AAH57385)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 453 AA; 49656 MW; B6EB88592B0ED514 CRC64;
METRGPGLAV RAESRRLVGI GPRAPPGRVG LQPSGRLDRR GGAGTMGYKD NDGEEEEREG
GAAGPRGSRL PPITGGASEL AKRKVKKKKR KKKTKGSGKG DDKHQSQSLK SQPLSSSFHD
ILSPCKERGP KPEHRQSKVE KKHLPSDSST VSLPDFAEIE NLANRINESL RWDGILADPE
AEKERIRIYK LNRRKRYRCL ALKGFHPDPE ALKGFHPDPD ALKGFHPDPE ALKGFHPDPE
ALKGFHPDPE ALKGFHPDPE ALKGIHPDPE ALKGIHPDPE ALKGFHPDPE ALKGFHPDPE
ALKGFHTDPE ALKGFHIDPE ALKGFHPDPK ALKGFHPDPK ALKGFHTDPE ALKGFHPDPK
ALKGFHPDPE ALKGFHPDPE ALKGFHPDPE ALKGFHTDPN AEEAPENLPY LSDKDGSSSH
RQPTSKAECP NLCFEGNLTP KLLHSDLAPT LLE
