LIAT1_MOUSE
ID LIAT1_MOUSE Reviewed; 228 AA.
AC Q810M6;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein LIAT1 {ECO:0000305|PubMed:25369936};
DE AltName: Full=Ligand of ATE1 protein {ECO:0000305|PubMed:25369936};
GN Name=Liat1 {ECO:0000303|PubMed:25369936};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, INTERACTION WITH ATE1; JMJD6 AND MRPS14, TISSUE SPECIFICITY, AND
RP DOMAIN.
RX PubMed=25369936; DOI=10.1073/pnas.1419587111;
RA Brower C.S., Rosen C.E., Jones R.H., Wadas B.C., Piatkov K.I.,
RA Varshavsky A.;
RT "Liat1, an arginyltransferase-binding protein whose evolution among
RT primates involved changes in the numbers of its 10-residue repeats.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:E4936-E4945(2014).
CC -!- FUNCTION: May be involved in ATE1-mediated N-terminal arginylation.
CC {ECO:0000269|PubMed:25369936}.
CC -!- SUBUNIT: Interacts with ATE1; it is not a substrate of LIAT1. Interacts
CC with JMJD6 and MRPS14. {ECO:0000269|PubMed:25369936}.
CC -!- TISSUE SPECIFICITY: Highly expressed in spleen, thymus, liver and brown
CC adipose tissue. Moderately expressed in liver, testis and lung.
CC {ECO:0000269|PubMed:25369936}.
CC -!- DOMAIN: LIAT1 proteins of some primates, from macaques to humans,
CC contain tandem repeats of a 10-residue sequence, whereas LIAT1 proteins
CC of other mammals contain a single copy of this motif. Quantities of
CC these repeats are, in general, different in LIAT1 of different
CC primates. For example, there are 1, 4, 13, 13, 17, and 17 repeats in
CC the gibbon, gorilla, orangutan, bonobo, neanderthal, and human LIAT1,
CC respectively. {ECO:0000305|PubMed:25369936}.
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DR EMBL; AK132806; BAE21367.1; -; mRNA.
DR EMBL; AL645569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049758; AAH49758.1; -; mRNA.
DR CCDS; CCDS25059.1; -.
DR RefSeq; NP_941039.1; NM_198637.2.
DR AlphaFoldDB; Q810M6; -.
DR STRING; 10090.ENSMUSP00000063358; -.
DR PhosphoSitePlus; Q810M6; -.
DR PaxDb; Q810M6; -.
DR PRIDE; Q810M6; -.
DR ProteomicsDB; 265069; -.
DR Antibodypedia; 10251; 46 antibodies from 12 providers.
DR Ensembl; ENSMUST00000066408; ENSMUSP00000063358; ENSMUSG00000053783.
DR GeneID; 74230; -.
DR KEGG; mmu:74230; -.
DR UCSC; uc007key.2; mouse.
DR MGI; MGI:1921480; 1700016K19Rik.
DR VEuPathDB; HostDB:ENSMUSG00000053783; -.
DR eggNOG; ENOG502SC86; Eukaryota.
DR GeneTree; ENSGT00440000038370; -.
DR HOGENOM; CLU_083042_0_0_1; -.
DR InParanoid; Q810M6; -.
DR OMA; SKDHGPR; -.
DR OrthoDB; 1530041at2759; -.
DR PhylomeDB; Q810M6; -.
DR TreeFam; TF337007; -.
DR BioGRID-ORCS; 74230; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q810M6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q810M6; protein.
DR Bgee; ENSMUSG00000053783; Expressed in seminiferous tubule of testis and 61 other tissues.
DR Genevisible; Q810M6; MM.
DR GO; GO:0016598; P:protein arginylation; IDA:UniProtKB.
DR InterPro; IPR038794; LIAT1.
DR PANTHER; PTHR36474; PTHR36474; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..228
FT /note="Protein LIAT1"
FT /id="PRO_0000340234"
FT REPEAT 169..178
FT /note="1"
FT /evidence="ECO:0000250|UniProtKB:Q6ZQX7"
FT REGION 1..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..165
FT /note="Interaction with ATE1"
FT /evidence="ECO:0000269|PubMed:25369936"
FT COMPBIAS 12..26
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 228 AA; 25512 MW; 0DDABD34E39DB504 CRC64;
MAGRGGTGAA EYGEEGEEEE EEEAREGGAE GSPGSKLPPI VGTASELAKR KVKKKKKKKK
TKGSGKGDAD KHHSRGRKNQ PLSSSFHDIL NPHKDHGLRA EPRDKEENRQ TLPYSYSINH
PCFAEIEDTL SSQINESLRW DGILTDPEAE KERIRIYKLN RRKRYRLMAL KCFHSDPCVE
ESVENLPYLS DKDCSPCSKQ PSSKGDHAHS YFEASKLLHP ELATTVAE
