ID   LIC2B_HAEIF             Reviewed;         266 AA.
AC   Q57394;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Lipooligosaccharide biosynthesis protein lic2B;
DE            EC=2.-.-.-;
GN   Name=lic2B;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INVOLVEMENT IN LIPOOLIGOSACCHARIDE
RP   SYNTHESIS.
RC   STRAIN=RM 7004 / Serotype B;
RX   PubMed=8861214; DOI=10.1111/j.1365-2958.1996.tb02498.x;
RA   High N.J., Jennings M.P., Moxon E.R.;
RT   "Tandem repeats of the tetramer 5'-CAAT-3' present in lic2A are required
RT   for phase variation but not lipopolysaccharide biosynthesis in Haemophilus
RT   influenzae.";
RL   Mol. Microbiol. 20:165-174(1996).
CC   -!- FUNCTION: Involved in extracellular lipooligosaccharide (LOS)
CC       biosynthesis and virulence expression. Involved in the synthesis of the
CC       oligosaccharide moiety of the LOS molecule by adding GalNAc (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 25 family.
CC       {ECO:0000305}.
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DR   EMBL; Z54182; CAA90892.1; -; Genomic_DNA.
DR   EMBL; U36398; AAA84947.1; -; Genomic_DNA.
DR   PIR; S71025; S71025.
DR   AlphaFoldDB; Q57394; -.
DR   CAZy; GT25; Glycosyltransferase Family 25.
DR   GO; GO:0016757; F:glycosyltransferase activity; IMP:CACAO.
DR   CDD; cd06532; Glyco_transf_25; 1.
DR   InterPro; IPR002654; Glyco_trans_25.
DR   Pfam; PF01755; Glyco_transf_25; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Transferase; Virulence.
FT   CHAIN           1..266
FT                   /note="Lipooligosaccharide biosynthesis protein lic2B"
FT                   /id="PRO_0000216234"
SQ   SEQUENCE   266 AA;  31131 MW;  0C68AE9BA249BD39 CRC64;
     MHINYVISLT SAYQRREHIQ KEFSQQNIPF EFFDALKPSK ELTSLIEKFI PNLLHAKLTE
     GEKACFMSHY MLWQKCFSED LPYIYIFEDD VLLGENADKF LAEDEWLEEA FKQTDKFILR
     FETFLNFSKC KDKKIKPYSG RKILKLVSEN CGAAGYVISR EAVKQLSAHI CSLTSNHLLA
     IDLLMFNIFN QSTYQVSPGV CVQEGQLYPK DIKLHSQLET ERQKYLSVKK KRTLKTVLIS
     LAGKPKKILR KIYRKLFISK HIVPFR