ID   LIC4_KLULA              Reviewed;         283 AA.
AC   Q6CQB7; Q9Y851;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Protein ATC1/LIC4;
GN   Name=ATC1; OrderedLocusNames=KLLA0D18326g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 157-283.
RC   STRAIN=ATCC 76492 / CBS 2359/152 / CLIB 210;
RX   PubMed=10669872;
RX   DOI=10.1002/1097-0061(20000315)16:4<343::aid-yea534>3.0.co;2-f;
RA   Bao W.-G., Fukuhara H.;
RT   "The ubiquitin-encoding genes of Kluyveromyces lactis.";
RL   Yeast 16:343-351(2000).
CC   -!- FUNCTION: Involved in cation homeostasis and in the regulation of the
CC       cation stress signaling cascades. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; CR382124; CAH00968.1; -; Genomic_DNA.
DR   EMBL; AJ243802; CAB50895.1; -; Genomic_DNA.
DR   RefSeq; XP_453872.1; XM_453872.1.
DR   AlphaFoldDB; Q6CQB7; -.
DR   SMR; Q6CQB7; -.
DR   STRING; 28985.XP_453872.1; -.
DR   EnsemblFungi; CAH00968; CAH00968; KLLA0_D18326g.
DR   GeneID; 2893476; -.
DR   KEGG; kla:KLLA0_D18326g; -.
DR   eggNOG; ENOG502S4IW; Eukaryota.
DR   HOGENOM; CLU_983745_0_0_1; -.
DR   InParanoid; Q6CQB7; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..283
FT                   /note="Protein ATC1/LIC4"
FT                   /id="PRO_0000076238"
FT   REGION          148..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   283 AA;  32162 MW;  D8A1A4EA91F11243 CRC64;
     MYQSMDLDDI KGHSHIINED AEFDKTDSDN TFALELQKII QQETNGGKVQ DDVLAEAIAT
     VDVDLPYLSN VSSPGLVYGT NKQSEHPQSH GGKDSDLTVE HILGDLQSGT EDDKEFTDRL
     NRLLCAPDSL KRGFSGDMEI DIPSNKKRKS VYETLSPPES MSPLSDKNDA QQNRDLNTHK
     DFSAMKRKIN SQRMLKQVPL PPKLTNEFTM TQVAEMKKRV INTHKLILNF NFLKDGYARS
     CEELSKTVVK LKDSEFDRAR LVKENQDLKR MVLEMSKQLN EKQ