ID   LICA1_HAEIN             Reviewed;         267 AA.
AC   P71392;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Protein LicA;
GN   Name=licA; OrderedLocusNames=HI_1537;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Mediates phase variation of the LPS epitopes. Phase variation
CC       of H.influenza LPS epitopes expressed by LicA is determined by a
CC       translational switch (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: Lipopolysaccharide (LPS) is a glycolipid that is a
CC       necessary component and antigenic determinant of the outer membrane and
CC       has been shown to be an important factor in the host-parasite
CC       interaction in a number of Gram-negative species.
CC   -!- MISCELLANEOUS: H.influenzae is able to display an extensive repertoire
CC       of different surface configurations through variability of its LPS
CC       oligosaccharide.
CC   -!- SIMILARITY: Belongs to the peptidase S49 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC23187.1; -; Genomic_DNA.
DR   PIR; B64128; B64128.
DR   RefSeq; NP_439686.1; NC_000907.1.
DR   AlphaFoldDB; P71392; -.
DR   SMR; P71392; -.
DR   STRING; 71421.HI_1537; -.
DR   DNASU; 950399; -.
DR   EnsemblBacteria; AAC23187; AAC23187; HI_1537.
DR   KEGG; hin:HI_1537; -.
DR   PATRIC; fig|71421.8.peg.1608; -.
DR   eggNOG; COG0510; Bacteria.
DR   HOGENOM; CLU_055115_1_0_6; -.
DR   OMA; WVFHVIR; -.
DR   PhylomeDB; P71392; -.
DR   BioCyc; HINF71421:G1GJ1-1557-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004305; F:ethanolamine kinase activity; IBA:GO_Central.
DR   GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..267
FT                   /note="Protein LicA"
FT                   /id="PRO_0000171451"
SQ   SEQUENCE   267 AA;  31395 MW;  BA4866B07E87E1DD CRC64;
     MTNQNVLLNI SGVKFVLRIP NAVNLSLINR EYEAFNNAQA YRAGLNVETP VLDAKSGVKL
     TRYLENSNTL SQIQLNEQSC LSQVVNNLYR LHNSEFVFRN VFSVFDEFRQ YFSLLENKSA
     FYQADSRMDK LSAVFWQFEE INKEVILRPC HNDLVPENML LQDDRLFFID WEYSGLNDPL
     FDIATIIEEA HLSKEAADFL LETYCNQTNK YHKTEFQIAH KRLKIHRFCQ NVLWFLWTKV
     KEEHGENFGD YALKRLDAAF KLLEELP