LICA2_HAEIF
ID LICA2_HAEIF Reviewed; 339 AA.
AC P14181;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Protein LicA;
GN Name=licA; Synonyms=lic1A;
OS Haemophilus influenzae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=727;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RM 7004 / Serotype B;
RX PubMed=2479481; DOI=10.1016/0092-8674(89)90011-1;
RA Weiser J.N., Love J.M., Moxon E.R.;
RT "The molecular mechanism of phase variation of H. influenzae
RT lipopolysaccharide.";
RL Cell 59:657-665(1989).
RN [2]
RP EXTENT OF VARIATION IN REPEAT NUMBERS.
RC STRAIN=26 strains, and RM 7004 / Serotype B;
RX PubMed=8861214; DOI=10.1111/j.1365-2958.1996.tb02498.x;
RA High N.J., Jennings M.P., Moxon E.R.;
RT "Tandem repeats of the tetramer 5'-CAAT-3' present in lic2A are required
RT for phase variation but not lipopolysaccharide biosynthesis in Haemophilus
RT influenzae.";
RL Mol. Microbiol. 20:165-174(1996).
CC -!- FUNCTION: Mediates phase variation of the LOS 6A2 and 12D9 epitopes.
CC Phase variation of H.influenza LOS epitopes expressed by LicA is
CC determined by a translational switch.
CC -!- DOMAIN: Between 2 and 19 copies of the INQS repeats are to be found in
CC different strains; these are thought to serve to generate phase-
CC variable expression of this gene.
CC -!- MISCELLANEOUS: There is spontaneous, high frequency switching between
CC three discrete levels of expression (++++, +, -) of oligosaccharide
CC epitopes.
CC -!- MISCELLANEOUS: Lipooligosaccharide (LOS) is a glycolipid that is a
CC necessary component and antigenic determinant of the outer membrane and
CC has been shown to be an important factor in the host-parasite
CC interaction in a number of Gram-negative species.
CC -!- MISCELLANEOUS: H.influenzae is able to display an extensive repertoire
CC of different surface configurations through variability of its LOS.
CC -!- SIMILARITY: Belongs to the peptidase S49 family. {ECO:0000305}.
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DR EMBL; M27280; AAA24971.1; -; Genomic_DNA.
DR PIR; A33465; A33465.
DR AlphaFoldDB; P14181; -.
DR SMR; P14181; -.
DR BRENDA; 2.7.1.32; 2529.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR SUPFAM; SSF56112; SSF56112; 1.
PE 3: Inferred from homology;
KW Repeat.
FT CHAIN 1..339
FT /note="Protein LicA"
FT /id="PRO_0000171452"
FT REPEAT 4..7
FT /note="1"
FT /evidence="ECO:0000269|PubMed:8861214"
FT REPEAT 8..11
FT /note="2"
FT /evidence="ECO:0000269|PubMed:8861214"
FT REPEAT 12..15
FT /note="3"
FT /evidence="ECO:0000269|PubMed:8861214"
FT REPEAT 16..19
FT /note="4"
FT /evidence="ECO:0000269|PubMed:8861214"
FT REPEAT 20..23
FT /note="5"
FT /evidence="ECO:0000269|PubMed:8861214"
FT REPEAT 24..27
FT /note="6"
FT /evidence="ECO:0000269|PubMed:8861214"
FT REPEAT 28..31
FT /note="7"
FT /evidence="ECO:0000269|PubMed:8861214"
FT REPEAT 32..35
FT /note="8"
FT /evidence="ECO:0000269|PubMed:8861214"
FT REPEAT 36..39
FT /note="9"
FT /evidence="ECO:0000269|PubMed:8861214"
FT REGION 4..39
FT /note="9 X 4 AA tandem repeats of I-N-Q-S"
FT VARIANT 1..3
FT /note="MQS -> IQKCYA (- phenotype)"
FT VARIANT 1
FT /note="M -> MNTKMLCN (++++ phenotype)"
SQ SEQUENCE 339 AA; 39466 MW; BAA4806828817743 CRC64;
MQSINQSINQ SINQSINQSI NQSINQSINQ SINQSINQSI NQIVGFVKTC YKPEEVFHFL
HQHSIPFSSI GGMTNQNVLL NISGVKFVLR IPNAVNLSLI NREYEAFNNA QAYRAGLNVE
TPVLDAKSGV KLTRYLENSN TLSQIQLNEQ SCLSQVVNNL YRLHNSEFVF RNVFSVFDEF
RQYFSLLENK SAFYQADSRM DKLSAVFWQF EEINKDIILR PCHNDLVPEN MLLQDDRLFF
IDWEYSGLND PLFDIATIIE EAHLSKEAAD FLLETYCNQT NKYHKTEFQI AHKRLKIHRF
CQNVLWFLWT KVKEEHGENF GDYALKRLDA AFKLLEELP
