ID   LICA_BACIU              Reviewed;          12 AA.
AC   P83878;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 1.
DT   11-DEC-2019, entry version 31.
DE   RecName: Full=Subpeptin JM4-A;
OS   Bacillus subtilis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1423;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP   STAGE, AND MASS SPECTROMETRY.
RC   STRAIN=JM4;
RX   PubMed=16211432; DOI=10.1007/s00284-005-0004-3;
RA   Wu S.-M., Jia S.-F., Sun D.-D., Chen M.-L., Chen X., Zhong J., Huan L.-D.;
RT   "Purification and characterization of two novel antimicrobial peptides
RT   Subpeptin JM4-A and Subpeptin JM4-B produced by Bacillus subtilis JM4.";
RL   Curr. Microbiol. 51:292-296(2005).
CC   -!- FUNCTION: Has antibacterial activity against Gram-positive and Gram-
CC       negative bacteria including Salmonella, B.cereus, B.megaterium,
CC       L.casei, L.viridescens, M.flavus, C.glutamicum, C.crenatum,
CC       L.mesenteroides and E.faecalis. {ECO:0000269|PubMed:16211432}.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Active from pH 2.0 to 8.0. Retains some activity up to pH 12.0.;
CC       Temperature dependence:
CC         Active from 20 to 100 degrees Celsius.;
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:16211432}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16211432}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from the mid-exponential phase, maximum
CC       activity is reached at the stationary phase.
CC       {ECO:0000269|PubMed:16211432}.
CC   -!- MASS SPECTROMETRY: Mass=1422.71; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16211432};
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Secreted.
FT   PEPTIDE         1..12
FT                   /note="Subpeptin JM4-A"
FT                   /id="PRO_0000044152"
SQ   SEQUENCE   12 AA;  1535 MW;  1C03499EF8436AE0 CRC64;
     XXKEIXWIFH DN