LICB_HAEIN
ID LICB_HAEIN Reviewed; 292 AA.
AC P14182; O05075; Q57357;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein LicB;
GN Name=licB; OrderedLocusNames=HI_1538;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RM 7004 / Serotype B;
RX PubMed=2479481; DOI=10.1016/0092-8674(89)90011-1;
RA Weiser J.N., Love J.M., Moxon E.R.;
RT "The molecular mechanism of phase variation of H. influenzae
RT lipopolysaccharide.";
RL Cell 59:657-665(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- MISCELLANEOUS: Lipopolysaccharide (LPS) is a glycolipid that is a
CC necessary component and antigenic determinant of the outer membrane and
CC has been shown to be an important factor in the host-parasite
CC interaction in a number of Gram-negative species.
CC -!- MISCELLANEOUS: H.influenzae is able to display an extensive repertoire
CC of different surface configurations through variability of its LPS
CC oligosaccharide.
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DR EMBL; M27280; AAA24972.1; -; Genomic_DNA.
DR EMBL; L42023; AAC23188.1; -; Genomic_DNA.
DR PIR; B33465; B33465.
DR RefSeq; NP_439687.1; NC_000907.1.
DR RefSeq; WP_005672105.1; NC_000907.1.
DR AlphaFoldDB; P14182; -.
DR SMR; P14182; -.
DR STRING; 71421.HI_1538; -.
DR TCDB; 2.A.7.18.1; the drug/metabolite transporter (dmt) superfamily.
DR EnsemblBacteria; AAC23188; AAC23188; HI_1538.
DR KEGG; hin:HI_1538; -.
DR PATRIC; fig|71421.8.peg.1609; -.
DR eggNOG; COG0697; Bacteria.
DR HOGENOM; CLU_044169_1_0_6; -.
DR OMA; NITYVVW; -.
DR BioCyc; HINF71421:G1GJ1-1558-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 2.
PE 4: Predicted;
KW Reference proteome; Repeat.
FT CHAIN 1..292
FT /note="Protein LicB"
FT /id="PRO_0000084417"
FT DOMAIN 70..139
FT /note="EamA 1"
FT DOMAIN 160..286
FT /note="EamA 2"
FT CONFLICT 251
FT /note="S -> L (in Ref. 1; AAA24972)"
FT /evidence="ECO:0000305"
FT CONFLICT 282..292
FT /note="IVTLYYKGEQK -> TLHFITKGNKNECNHFSSRIRQSF (in Ref. 1;
FT AAA24972)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 292 AA; 32449 MW; 43359398135F7B94 CRC64;
MRGYLFGILS AVFWALSGLL YNELPLSEYT ALGKVISLLF LIDFCSLLVI GITLWRKSAV
DFQGVFWQPA LSGILGGPIG MSAYLLSIHY LTIYYAAPLS SLFPVFAALM SYWILKEKIT
KTAQFGFALA IISSSLLAIE VGQEITFNTI GFIFLIICIL GWSSEIVISS YTMRSLSGLQ
VYFLRLCGST IGYLLILFIL SLKNFSLDIL SFNYVQIAGV IIFGALSYCC YYQAIYLLKP
IKAMALNITY SVWAIGLGYL LYKQPIKPIT LLLTLLLSAG VIVTLYYKGE QK
