LICC_HAEIN
ID LICC_HAEIN Reviewed; 233 AA.
AC P14183; O05076;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein LicC;
GN Name=licC; OrderedLocusNames=HI_1539;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RM 7004 / Serotype B;
RX PubMed=2479481; DOI=10.1016/0092-8674(89)90011-1;
RA Weiser J.N., Love J.M., Moxon E.R.;
RT "The molecular mechanism of phase variation of H. influenzae
RT lipopolysaccharide.";
RL Cell 59:657-665(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- MISCELLANEOUS: Lipopolysaccharide (LPS) is a glycolipid that is a
CC necessary component and antigenic determinant of the outer membrane and
CC has been shown to be an important factor in the host-parasite
CC interaction in a number of Gram-negative species.
CC -!- MISCELLANEOUS: H.influenzae is able to display an extensive repertoire
CC of different surface configurations through variability of its LPS
CC oligosaccharide.
CC -!- MISCELLANEOUS: LicC is critical for the expression of the 6A2-specific
CC epitope.
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DR EMBL; M27280; AAA24973.1; -; Genomic_DNA.
DR EMBL; L42023; AAC23189.1; -; Genomic_DNA.
DR PIR; C33465; C33465.
DR PIR; D64128; D64128.
DR RefSeq; NP_439688.1; NC_000907.1.
DR RefSeq; WP_005693563.1; NC_000907.1.
DR AlphaFoldDB; P14183; -.
DR SMR; P14183; -.
DR STRING; 71421.HI_1539; -.
DR EnsemblBacteria; AAC23189; AAC23189; HI_1539.
DR KEGG; hin:HI_1539; -.
DR PATRIC; fig|71421.8.peg.1610; -.
DR eggNOG; COG4750; Bacteria.
DR HOGENOM; CLU_029499_5_2_6; -.
DR OMA; KNPKLYW; -.
DR PhylomeDB; P14183; -.
DR BioCyc; HINF71421:G1GJ1-1559-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR017189; CTP-phospocholine_CTT.
DR InterPro; IPR025877; MobA-like_NTP_Trfase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF12804; NTP_transf_3; 1.
DR PIRSF; PIRSF037382; CCT_LicC; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 4: Predicted;
KW Reference proteome.
FT CHAIN 1..233
FT /note="Protein LicC"
FT /id="PRO_0000084418"
FT CONFLICT 118
FT /note="K -> R (in Ref. 1; AAA24973)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="I -> M (in Ref. 1; AAA24973)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="D -> E (in Ref. 1; AAA24973)"
FT /evidence="ECO:0000305"
FT CONFLICT 157..159
FT /note="ISF -> VSY (in Ref. 1; AAA24973)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="Q -> R (in Ref. 1; AAA24973)"
FT /evidence="ECO:0000305"
FT CONFLICT 198..233
FT /note="KLNIYTEQLNSDDIFEMDNLDDYHHILQKLTPNKEK -> N (in Ref.
FT 1; AAA24973)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 233 AA; 27319 MW; 5123FBF35AC29E55 CRC64;
MNAIILAAGL GSRFKDITQS THKSLLDIHG TPNLERTLTF LRQANIDNIV IVTGYLHEQF
EYLKKKYDCT LIYNEKYREY NSIYSFSLAQ DFFNDCYVID ADVVLNRNIF LTKPSHSKYF
TVIRSKTHNE WLPILNSNGQ VIRIDIGSLN QPSLSGISFW TTQDCNIILT LLKEYTSEVR
LKNPKLYWDT IPMEYIEKLN IYTEQLNSDD IFEMDNLDDY HHILQKLTPN KEK
