LICD_HAEIN
ID LICD_HAEIN Reviewed; 265 AA.
AC P14184; P71393;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Lipopolysaccharide cholinephosphotransferase LicD;
DE EC=2.7.8.-;
GN Name=licD; OrderedLocusNames=HI_1540;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RM 7004 / Serotype B;
RX PubMed=2479481; DOI=10.1016/0092-8674(89)90011-1;
RA Weiser J.N., Love J.M., Moxon E.R.;
RT "The molecular mechanism of phase variation of H. influenzae
RT lipopolysaccharide.";
RL Cell 59:657-665(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [3]
RP FUNCTION.
RX PubMed=10632893; DOI=10.1046/j.1365-2958.2000.01707.x;
RA Lysenko E., Richards J.C., Cox A.D., Stewart A., Martin A., Kapoor M.,
RA Weiser J.N.;
RT "The position of phosphorylcholine on the lipopolysaccharide of Haemophilus
RT influenzae affects binding and sensitivity to C-reactive protein-mediated
RT killing.";
RL Mol. Microbiol. 35:234-245(2000).
CC -!- FUNCTION: Transfers phosphorylcholine (ChoP) from choline
CC diphosphonucleoside to the lipopolysaccharide (LPS).
CC {ECO:0000269|PubMed:10632893}.
CC -!- MISCELLANEOUS: Lipopolysaccharide (LPS) is a glycolipid that is a
CC necessary component and antigenic determinant of the outer membrane and
CC has been shown to be an important factor in the host-parasite
CC interaction in a number of Gram-negative species.
CC -!- MISCELLANEOUS: H.influenzae is able to display an extensive repertoire
CC of different surface configurations through variability of its LPS
CC oligosaccharide.
CC -!- MISCELLANEOUS: LicD is required for the expression of the 12D9-specific
CC epitope.
CC -!- SIMILARITY: Belongs to the LicD transferase family. {ECO:0000305}.
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DR EMBL; M27280; AAA24974.1; -; Genomic_DNA.
DR EMBL; L42023; AAC23190.1; -; Genomic_DNA.
DR PIR; D33465; D33465.
DR PIR; E64128; E64128.
DR RefSeq; NP_439689.1; NC_000907.1.
DR RefSeq; WP_005693564.1; NC_000907.1.
DR AlphaFoldDB; P14184; -.
DR STRING; 71421.HI_1540; -.
DR EnsemblBacteria; AAC23190; AAC23190; HI_1540.
DR KEGG; hin:HI_1540; -.
DR PATRIC; fig|71421.8.peg.1611; -.
DR eggNOG; COG3475; Bacteria.
DR HOGENOM; CLU_075543_1_0_6; -.
DR OMA; IYDGVPN; -.
DR PhylomeDB; P14184; -.
DR BioCyc; HINF71421:G1GJ1-1560-MON; -.
DR BioCyc; MetaCyc:MON-18962; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR007074; LicD_fam.
DR Pfam; PF04991; LicD; 1.
PE 3: Inferred from homology;
KW Lipopolysaccharide biosynthesis; Reference proteome; Transferase.
FT CHAIN 1..265
FT /note="Lipopolysaccharide cholinephosphotransferase LicD"
FT /id="PRO_0000204725"
FT CONFLICT 27..30
FT /note="YKIS -> HQIH (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 77
FT /note="H -> Y (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 80
FT /note="M -> I (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 83
FT /note="A -> V (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 90
FT /note="Y -> K (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 106..116
FT /note="DAKGRKSPMFM -> EIAGKKSAMFI (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="E -> D (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 132..134
FT /note="YPL -> CSF (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 138..146
FT /note="HRRIKLRFS -> YRRTHRRFY (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 154
FT /note="R -> K (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 160..161
FT /note="VQ -> LW (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 171..172
FT /note="FL -> LI (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 181
FT /note="A -> E (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="K -> T (in Ref. 1; AAA24974)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="Y -> YDDY (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 265 AA; 31873 MW; D59EE2BA4D6D49A4 CRC64;
MKKLTLREQQ LVCLNILDYF HALCERYKIS YSLGGGTLIG AIRHKGFIPW DDDIDVYMHR
DEYQRFVDVW FQETHEHYNM ETAEDILAQY TGEMAKIFDC RTQITDAKGR KSPMFMDIFI
YDGVPNEPKI IYPLMKKHRR IKLRFSSCKK RWLRAKENTV QKAILNKLSH FLFSKMQKNL
AQFQIKYPIK QCDYIGLVLS DYGGWQKSYM PKEYFNHVIY KEFEGRQFQV MNGYHEHLTQ
YYGDYMKLPP EEDQKPHHIQ EAYIL
