LICT_BACSU
ID LICT_BACSU Reviewed; 277 AA.
AC P39805;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Transcription antiterminator LicT;
GN Name=licT; OrderedLocusNames=BSU39080; ORFNames=N15A;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BR151;
RX PubMed=8606172; DOI=10.1128/jb.178.7.1971-1979.1996;
RA Schnetz K., Stuelke J., Gertz S., Krueger S., Krieg M., Hecker M., Rak B.;
RT "LicT, a Bacillus subtilis transcriptional antiterminator protein of the
RT BglG family.";
RL J. Bacteriol. 178:1971-1979(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BGSC1A1;
RX PubMed=8969509; DOI=10.1099/13500872-142-11-3113;
RA Yoshida K., Shindo K., Sano H., Seki S., Fujimura M., Yanai N., Miwa Y.,
RA Fujita Y.;
RT "Sequencing of a 65 kb region of the Bacillus subtilis genome containing
RT the lic and cel loci, and creation of a 177 kb contig covering the gnt-
RT sacXY region.";
RL Microbiology 142:3113-3123(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP SEQUENCE REVISION TO 79.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 193-277.
RX PubMed=6087283; DOI=10.1093/nar/12.13.5355;
RA Murphy N., McConnell D.J., Cantwell B.A.;
RT "The DNA sequence of the gene and genetic control sites for the excreted B.
RT subtilis enzyme beta-glucanase.";
RL Nucleic Acids Res. 12:5355-5367(1984).
CC -!- FUNCTION: Mediates positive regulation of the glucanase operon (licST)
CC by functioning as an antiterminator factor of transcription. Prevents
CC termination at terminator lic-t.
CC -!- PTM: Phosphorylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the transcriptional antiterminator BglG family.
CC {ECO:0000305}.
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DR EMBL; Z28340; CAA82194.1; -; Genomic_DNA.
DR EMBL; D83026; BAA11696.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15944.2; -; Genomic_DNA.
DR EMBL; X00754; CAA25326.1; -; Genomic_DNA.
DR PIR; S47216; S47216.
DR RefSeq; NP_391787.2; NC_000964.3.
DR RefSeq; WP_003242598.1; NZ_JNCM01000034.1.
DR PDB; 1H99; X-ray; 1.55 A; A=57-277.
DR PDB; 1L1C; NMR; -; A/B=1-55.
DR PDB; 1TLV; X-ray; 1.95 A; A=57-274.
DR PDB; 6TWR; NMR; -; A/B=1-167.
DR PDBsum; 1H99; -.
DR PDBsum; 1L1C; -.
DR PDBsum; 1TLV; -.
DR PDBsum; 6TWR; -.
DR AlphaFoldDB; P39805; -.
DR BMRB; P39805; -.
DR SMR; P39805; -.
DR STRING; 224308.BSU39080; -.
DR DrugBank; DB04530; S,S-(2-Hydroxyethyl)Thiocysteine.
DR jPOST; P39805; -.
DR PaxDb; P39805; -.
DR PRIDE; P39805; -.
DR EnsemblBacteria; CAB15944; CAB15944; BSU_39080.
DR GeneID; 937503; -.
DR KEGG; bsu:BSU39080; -.
DR PATRIC; fig|224308.179.peg.4231; -.
DR eggNOG; COG3711; Bacteria.
DR InParanoid; P39805; -.
DR OMA; CSIALHI; -.
DR PhylomeDB; P39805; -.
DR BioCyc; BSUB:BSU39080-MON; -.
DR EvolutionaryTrace; P39805; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
DR Gene3D; 2.30.24.10; -; 1.
DR InterPro; IPR004341; CAT_RNA-bd_dom.
DR InterPro; IPR036650; CAT_RNA-bd_dom_sf.
DR InterPro; IPR011608; PRD.
DR InterPro; IPR036634; PRD_sf.
DR InterPro; IPR001550; Transcrpt_antitermin_CS.
DR Pfam; PF03123; CAT_RBD; 1.
DR Pfam; PF00874; PRD; 2.
DR SMART; SM01061; CAT_RBD; 1.
DR SUPFAM; SSF50151; SSF50151; 1.
DR SUPFAM; SSF63520; SSF63520; 2.
DR PROSITE; PS00654; PRD_1; 1.
DR PROSITE; PS51372; PRD_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; Phosphoprotein; Reference proteome; Repeat;
KW RNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..277
FT /note="Transcription antiterminator LicT"
FT /id="PRO_0000204247"
FT DOMAIN 65..170
FT /note="PRD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00704"
FT DOMAIN 171..277
FT /note="PRD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00704"
FT CONFLICT 79
FT /note="S -> H (in Ref. 2; BAA11696)"
FT /evidence="ECO:0000305"
FT STRAND 3..8
FT /evidence="ECO:0007829|PDB:1L1C"
FT STRAND 11..15
FT /evidence="ECO:0007829|PDB:1L1C"
FT STRAND 21..25
FT /evidence="ECO:0007829|PDB:1L1C"
FT STRAND 27..30
FT /evidence="ECO:0007829|PDB:1L1C"
FT HELIX 41..43
FT /evidence="ECO:0007829|PDB:1L1C"
FT STRAND 45..51
FT /evidence="ECO:0007829|PDB:1L1C"
FT TURN 53..55
FT /evidence="ECO:0007829|PDB:6TWR"
FT HELIX 57..59
FT /evidence="ECO:0007829|PDB:1H99"
FT HELIX 63..65
FT /evidence="ECO:0007829|PDB:1TLV"
FT HELIX 68..85
FT /evidence="ECO:0007829|PDB:1H99"
FT HELIX 92..109
FT /evidence="ECO:0007829|PDB:1H99"
FT HELIX 119..125
FT /evidence="ECO:0007829|PDB:1H99"
FT HELIX 127..144
FT /evidence="ECO:0007829|PDB:1H99"
FT HELIX 150..164
FT /evidence="ECO:0007829|PDB:1H99"
FT HELIX 170..190
FT /evidence="ECO:0007829|PDB:1H99"
FT HELIX 199..217
FT /evidence="ECO:0007829|PDB:1H99"
FT HELIX 227..235
FT /evidence="ECO:0007829|PDB:1H99"
FT HELIX 237..254
FT /evidence="ECO:0007829|PDB:1H99"
FT HELIX 260..274
FT /evidence="ECO:0007829|PDB:1H99"
SQ SEQUENCE 277 AA; 32317 MW; E494702FD9B4C4A4 CRC64;
MKIAKVINNN VISVVNEQGK ELVVMGRGLA FQKKSGDDVD EARIEKVFTL DNKDVSEKFK
TLLYDIPIEC MEVSEEIISY AKLQLGKKLN DSIYVSLTDH INFAIQRNQK GLDIKNALLW
ETKRLYKDEF AIGKEALVMV KNKTGVSLPE DEAGFIALHI VNAELNEEMP NIINITKVMQ
EILSIVKYHF KIEFNEESLH YYRFVTHLKF FAQRLFNGTH MESQDDFLLD TVKEKYHRAY
ECTKKIQTYI EREYEHKLTS DELLYLTIHI ERVVKQA
