LIF_BOVIN
ID LIF_BOVIN Reviewed; 202 AA.
AC Q27956; O02804; P79116;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Leukemia inhibitory factor;
DE Short=LIF;
DE AltName: Full=bLIF;
DE Flags: Precursor;
GN Name=LIF;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Holstein; TISSUE=Mammary gland;
RA Kato Y., Kudo T., Sato S., Sutou S.;
RT "Cloning and sequence analysis of the bovine leukemia inhibitory factor
RT (LIF) gene.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Holstein; TISSUE=Endometrium;
RA Brisson C., Ethier J.-F., Lussier J.G., Goff A.K., Silversides D.W.;
RT "Bovine leukemia inhibitory factor (bLIF) is expressed in endometrial cell
RT primary culture and immortalized cell lines.";
RL Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9124702; DOI=10.1111/j.1365-2052.1997.00054.x;
RA Piedrahita J.A., Weaks R., Petrescu A., Shrode T.W., Derr J.N.,
RA Womack J.E.;
RT "Genetic characterization of the bovine leukaemia inhibitory factor (LIF)
RT gene: isolation and sequencing, chromosome assignment and microsatellite
RT analysis.";
RL Anim. Genet. 28:14-20(1997).
CC -!- FUNCTION: LIF has the capacity to induce terminal differentiation in
CC leukemic cells. Its activities include the induction of hematopoietic
CC differentiation in normal and myeloid leukemia cells, the induction of
CC neuronal cell differentiation, and the stimulation of acute-phase
CC protein synthesis in hepatocytes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the LIF/OSM family. {ECO:0000305}.
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DR EMBL; D50337; BAA19511.1; -; Genomic_DNA.
DR EMBL; U65394; AAB39324.1; -; mRNA.
DR EMBL; U63311; AAC27535.1; -; Genomic_DNA.
DR RefSeq; NP_776356.1; NM_173931.1.
DR RefSeq; XP_005218077.1; XM_005218020.3.
DR RefSeq; XP_015331027.1; XM_015475541.1.
DR AlphaFoldDB; Q27956; -.
DR SMR; Q27956; -.
DR STRING; 9913.ENSBTAP00000009761; -.
DR PaxDb; Q27956; -.
DR Ensembl; ENSBTAT00000009761; ENSBTAP00000009761; ENSBTAG00000007424.
DR GeneID; 280840; -.
DR KEGG; bta:280840; -.
DR CTD; 3976; -.
DR VEuPathDB; HostDB:ENSBTAG00000007424; -.
DR VGNC; VGNC:30880; LIF.
DR eggNOG; ENOG502S3JD; Eukaryota.
DR GeneTree; ENSGT00390000000059; -.
DR HOGENOM; CLU_117011_0_0_1; -.
DR InParanoid; Q27956; -.
DR OMA; DVSYGPD; -.
DR OrthoDB; 1240691at2759; -.
DR TreeFam; TF336245; -.
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000007424; Expressed in ureter and 67 other tissues.
DR ExpressionAtlas; Q27956; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005146; F:leukemia inhibitory factor receptor binding; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0048861; P:leukemia inhibitory factor signaling pathway; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0009893; P:positive regulation of metabolic process; IEA:UniProt.
DR GO; GO:0010646; P:regulation of cell communication; IEA:UniProt.
DR GO; GO:0045595; P:regulation of cell differentiation; IBA:GO_Central.
DR GO; GO:0023051; P:regulation of signaling; IEA:UniProt.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003624; Leukemia_IF.
DR InterPro; IPR001581; Leukemia_IF/oncostatin.
DR InterPro; IPR019827; Leukemia_IF/oncostatin_CS.
DR PANTHER; PTHR10633; PTHR10633; 1.
DR Pfam; PF01291; LIF_OSM; 1.
DR PRINTS; PR01883; LEUKAEMIAIF.
DR SMART; SM00080; LIF_OSM; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00590; LIF_OSM; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT CHAIN 23..202
FT /note="Leukemia inhibitory factor"
FT /id="PRO_0000017714"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 85
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 34..156
FT /evidence="ECO:0000250"
FT DISULFID 40..153
FT /evidence="ECO:0000250"
FT DISULFID 82..185
FT /evidence="ECO:0000250"
SQ SEQUENCE 202 AA; 22063 MW; 2FF441C8B1029E78 CRC64;
MKVLAAGVVP LLLVLHWKHG AGSPLPITPV NATCATRHPC PSNLMNQIRN QLGQLNSSAN
SLFILYYTAQ GEPFPNNLDK LCSPNVTDFP PFHANGTEKA RLVELYRIIA YLGASLGNIT
RDQKVLNPYA HGLHSKLSTT ADVLRGLLSN VLCRLCSKYH VSHVDVTYGP DTSGKDVFQK
KKLGCQLLGK YKQVIAVLAQ AF
