LIF_RAT
ID LIF_RAT Reviewed; 202 AA.
AC P17777;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Leukemia inhibitory factor;
DE Short=LIF;
DE AltName: Full=Cholinergic neuronal differentiation factor;
DE Flags: Precursor;
GN Name=Lif;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Heart;
RX PubMed=2512641; DOI=10.1126/science.2512641;
RA Yamamori T., Fukada K., Aebersold R., Korsching S., Fann M.-J.,
RA Patterson P.H.;
RT "The cholinergic neuronal differentiation factor from heart cells is
RT identical to leukemia inhibitory factor.";
RL Science 246:1412-1416(1989).
CC -!- FUNCTION: LIF has the capacity to induce terminal differentiation in
CC leukemic cells. Its activities include the induction of hematopoietic
CC differentiation in normal and myeloid leukemia cells, the induction of
CC neuronal cell differentiation, and the stimulation of acute-phase
CC protein synthesis in hepatocytes.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the LIF/OSM family. {ECO:0000305}.
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DR EMBL; M32748; AAA41530.1; -; mRNA.
DR PIR; A40078; A40078.
DR AlphaFoldDB; P17777; -.
DR SMR; P17777; -.
DR STRING; 10116.ENSRNOP00000009313; -.
DR GlyGen; P17777; 7 sites.
DR PaxDb; P17777; -.
DR PRIDE; P17777; -.
DR UCSC; RGD:620865; rat.
DR RGD; 620865; Lif.
DR eggNOG; ENOG502S3JD; Eukaryota.
DR InParanoid; P17777; -.
DR PhylomeDB; P17777; -.
DR Reactome; R-RNO-6788467; IL-6-type cytokine receptor ligand interactions.
DR PRO; PR:P17777; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0005125; F:cytokine activity; ISO:RGD.
DR GO; GO:0008083; F:growth factor activity; ISO:RGD.
DR GO; GO:0005146; F:leukemia inhibitory factor receptor binding; IMP:RGD.
DR GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR GO; GO:0031100; P:animal organ regeneration; IMP:RGD.
DR GO; GO:0048708; P:astrocyte differentiation; IMP:RGD.
DR GO; GO:0001974; P:blood vessel remodeling; ISO:RGD.
DR GO; GO:0046697; P:decidualization; ISO:RGD.
DR GO; GO:0007566; P:embryo implantation; ISO:RGD.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0048861; P:leukemia inhibitory factor signaling pathway; ISO:RGD.
DR GO; GO:0048286; P:lung alveolus development; ISO:RGD.
DR GO; GO:0030324; P:lung development; ISO:RGD.
DR GO; GO:0060463; P:lung lobe morphogenesis; ISO:RGD.
DR GO; GO:0060426; P:lung vasculature development; ISO:RGD.
DR GO; GO:0060135; P:maternal process involved in female pregnancy; ISO:RGD.
DR GO; GO:0048644; P:muscle organ morphogenesis; ISO:RGD.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IDA:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISO:RGD.
DR GO; GO:0046888; P:negative regulation of hormone secretion; ISO:RGD.
DR GO; GO:0045835; P:negative regulation of meiotic nuclear division; ISO:RGD.
DR GO; GO:0048666; P:neuron development; ISO:RGD.
DR GO; GO:0048711; P:positive regulation of astrocyte differentiation; ISO:RGD.
DR GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0051461; P:positive regulation of corticotropin secretion; IDA:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:1901676; P:positive regulation of histone H3-K27 acetylation; ISO:RGD.
DR GO; GO:0045651; P:positive regulation of macrophage differentiation; ISO:RGD.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR GO; GO:0072108; P:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; ISO:RGD.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IDA:RGD.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:RGD.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; ISO:RGD.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
DR GO; GO:1900182; P:positive regulation of protein localization to nucleus; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
DR GO; GO:0045595; P:regulation of cell differentiation; ISO:RGD.
DR GO; GO:0072307; P:regulation of metanephric nephron tubule epithelial cell differentiation; ISO:RGD.
DR GO; GO:1903025; P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0060041; P:retina development in camera-type eye; IDA:RGD.
DR GO; GO:0060708; P:spongiotrophoblast differentiation; ISO:RGD.
DR GO; GO:0048863; P:stem cell differentiation; ISO:RGD.
DR GO; GO:0019827; P:stem cell population maintenance; ISO:RGD.
DR GO; GO:0060290; P:transdifferentiation; IMP:RGD.
DR GO; GO:0060707; P:trophoblast giant cell differentiation; ISO:RGD.
DR GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; ISO:RGD.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003624; Leukemia_IF.
DR InterPro; IPR001581; Leukemia_IF/oncostatin.
DR InterPro; IPR019827; Leukemia_IF/oncostatin_CS.
DR PANTHER; PTHR10633; PTHR10633; 1.
DR Pfam; PF01291; LIF_OSM; 1.
DR PRINTS; PR01883; LEUKAEMIAIF.
DR SMART; SM00080; LIF_OSM; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00590; LIF_OSM; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT CHAIN 23..202
FT /note="Leukemia inhibitory factor"
FT /id="PRO_0000017718"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 85
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 34..156
FT /evidence="ECO:0000250"
FT DISULFID 40..153
FT /evidence="ECO:0000250"
FT DISULFID 82..185
FT /evidence="ECO:0000250"
SQ SEQUENCE 202 AA; 22113 MW; 022373582D296164 CRC64;
MKVLAAGIVP LLLILHWKHG AGSPLPITPV NATCAIRHPC HGNLMNQIKS QLAQLNGSAN
ALFISYYTAQ GEPFPNNVDK LCAPNMTDFP PFHANGTEKT KLVELYRMVT YLGASLTNIT
WDQKNLNPTA VSLQIKLNAT TDVMRGLLSS VLCRLCNKYH VGHVDVPCVP DNSSKEAFQR
KKLGCQLLGT YKQVISVLAQ AF
