LIG1B_DANRE
ID LIG1B_DANRE Reviewed; 622 AA.
AC Q66HV9; A8BAU5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1-B;
DE Flags: Precursor;
GN Name=lingo1b; Synonyms=lingo1; ORFNames=si:ch211-116a8.1, zgc:92338;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=18296487; DOI=10.1101/gr.7187808;
RA Bushell K.M., Soellner C., Schuster-Boeckler B., Bateman A., Wright G.J.;
RT "Large-scale screening for novel low-affinity extracellular protein
RT interactions.";
RL Genome Res. 18:622-630(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in regulating axonal regeneration and
CC plasticity in the adult central nervous system. {ECO:0000250}.
CC -!- INTERACTION:
CC Q66HV9; Q6NW92: igfbp7; NbExp=2; IntAct=EBI-2263743, EBI-1579483;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
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DR EMBL; CU468744; CAP07968.1; -; mRNA.
DR EMBL; BX470207; CAM13144.1; -; Genomic_DNA.
DR EMBL; BC081651; AAH81651.1; -; mRNA.
DR RefSeq; NP_001004576.1; NM_001004576.1.
DR AlphaFoldDB; Q66HV9; -.
DR SMR; Q66HV9; -.
DR IntAct; Q66HV9; 1.
DR STRING; 7955.ENSDARP00000052112; -.
DR PaxDb; Q66HV9; -.
DR Ensembl; ENSDART00000052113; ENSDARP00000052112; ENSDARG00000035899.
DR GeneID; 447837; -.
DR KEGG; dre:447837; -.
DR CTD; 447837; -.
DR ZFIN; ZDB-GENE-040912-136; lingo1b.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000154996; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; Q66HV9; -.
DR OMA; IMWQSPR; -.
DR OrthoDB; 399926at2759; -.
DR PhylomeDB; Q66HV9; -.
DR TreeFam; TF334360; -.
DR PRO; PR:Q66HV9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 7.
DR Bgee; ENSDARG00000035899; Expressed in anterior presumptive neural plate and 23 other tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0042552; P:myelination; IMP:ZFIN.
DR GO; GO:0048666; P:neuron development; IMP:ZFIN.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..43
FT /evidence="ECO:0000255"
FT CHAIN 44..622
FT /note="Leucine-rich repeat and immunoglobulin-like domain-
FT containing nogo receptor-interacting protein 1-B"
FT /id="PRO_0000328648"
FT TOPO_DOM 44..563
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 585..622
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 44..73
FT /note="LRRNT"
FT REPEAT 74..95
FT /note="LRR 1"
FT REPEAT 98..119
FT /note="LRR 2"
FT REPEAT 122..143
FT /note="LRR 3"
FT REPEAT 146..167
FT /note="LRR 4"
FT REPEAT 170..191
FT /note="LRR 5"
FT REPEAT 194..215
FT /note="LRR 6"
FT REPEAT 218..239
FT /note="LRR 7"
FT REPEAT 266..287
FT /note="LRR 8"
FT REPEAT 290..311
FT /note="LRR 9"
FT REPEAT 314..335
FT /note="LRR 10"
FT REPEAT 338..359
FT /note="LRR 11"
FT DOMAIN 371..425
FT /note="LRRCT"
FT DOMAIN 413..515
FT /note="Ig-like C2-type"
FT CARBOHYD 146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 266
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 343
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 494
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 507
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 528
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 544
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 44..50
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 48..59
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 375..398
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 377..423
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 448..499
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 622 AA; 70446 MW; 62BFF0139DB7F628 CRC64;
MTFLQVTIKM VAREASGHSY LVACWQPILI LMLGTVLSGS ATGCPSRCEC SAQERSVVCH
RRKLITLPEG IPIDTRLLDL SKNRLKAINP EEFLNYPQLE DLQLNENIIS VIEPGAFSNL
LGLRTLGLRN NNLKLIQLGV FTGLSNLTRL DISENKIVIL LDYMFQELYN LKELEVGDND
LVFISHRAFH GLSSLEQLTM ERCNLTSVPT EAFSHLHNLL TLKLRHLNVN VIRDFSFRRL
YRLKILEIAN WPLLESLTAK SLHGLNITTL SITNCNLTAV PYVAIQHLVY LRFFNLSFNP
IEVVEGNKMH NLLRLQAFHL VGGRLVSIEP YSFKGLNYLR VLNVSSNSLS TLEESAFHSV
GNLETLALHD NPLACDCRLL WVFRRRWRLN FNRQQPSCET PEFLQGKEFK DFPDVLPPNY
FTCQKSKIRD HKAIHRFVDE GTTVQFPCQA DGDPTPMIMW QSPKKQFITT KSIGRLSVSL
DGTLEVRYAQ IQDNGTYTCF AVNAGGNDTR LAHLHVHSYS PNWPHQPNKT FAFILNQPSD
NSANGTGAMD PFPFDMKTLI IATTMGFISF LGVVLFCLVL LFLWSRGKGN AKPNIEIEYV
PRKVDGENSP NEGSHKISMK MI
