LIGO2_HUMAN
ID LIGO2_HUMAN Reviewed; 606 AA.
AC Q7L985; A8K4K7; B2RPM5; Q6ZMD0;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2;
DE AltName: Full=Leucine-rich repeat neuronal protein 3;
DE AltName: Full=Leucine-rich repeat neuronal protein 6C;
DE Flags: Precursor;
GN Name=LINGO2; Synonyms=LERN3, LRRN6C; ORFNames=UNQ9234/PRO31993;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD18799.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY358114; AAQ88481.1; -; mRNA.
DR EMBL; AK056372; BAB71167.1; -; mRNA.
DR EMBL; AK172834; BAD18799.1; ALT_INIT; mRNA.
DR EMBL; AK290972; BAF83661.1; -; mRNA.
DR EMBL; CH471071; EAW58557.1; -; Genomic_DNA.
DR EMBL; BC137514; AAI37515.1; -; mRNA.
DR CCDS; CCDS6524.1; -.
DR RefSeq; NP_001245211.1; NM_001258282.1.
DR RefSeq; NP_689783.1; NM_152570.2.
DR RefSeq; XP_011516021.1; XM_011517719.1.
DR RefSeq; XP_011516026.1; XM_011517724.2.
DR RefSeq; XP_011516030.1; XM_011517728.2.
DR RefSeq; XP_016869792.1; XM_017014303.1.
DR RefSeq; XP_016869793.1; XM_017014304.1.
DR RefSeq; XP_016869794.1; XM_017014305.1.
DR RefSeq; XP_016869795.1; XM_017014306.1.
DR RefSeq; XP_016869796.1; XM_017014307.1.
DR AlphaFoldDB; Q7L985; -.
DR SMR; Q7L985; -.
DR BioGRID; 127640; 18.
DR IntAct; Q7L985; 11.
DR STRING; 9606.ENSP00000369328; -.
DR GlyGen; Q7L985; 5 sites.
DR iPTMnet; Q7L985; -.
DR PhosphoSitePlus; Q7L985; -.
DR BioMuta; LINGO2; -.
DR DMDM; 172046190; -.
DR jPOST; Q7L985; -.
DR MassIVE; Q7L985; -.
DR PaxDb; Q7L985; -.
DR PeptideAtlas; Q7L985; -.
DR PRIDE; Q7L985; -.
DR ProteomicsDB; 68843; -.
DR Antibodypedia; 3035; 149 antibodies from 23 providers.
DR DNASU; 158038; -.
DR Ensembl; ENST00000308675.5; ENSP00000310126.3; ENSG00000174482.10.
DR Ensembl; ENST00000379992.6; ENSP00000369328.1; ENSG00000174482.10.
DR Ensembl; ENST00000613945.3; ENSP00000479634.1; ENSG00000174482.10.
DR GeneID; 158038; -.
DR KEGG; hsa:158038; -.
DR UCSC; uc064smp.1; human.
DR CTD; 158038; -.
DR DisGeNET; 158038; -.
DR GeneCards; LINGO2; -.
DR HGNC; HGNC:21207; LINGO2.
DR HPA; ENSG00000174482; Tissue enhanced (endometrium, smooth muscle).
DR MIM; 609793; gene.
DR neXtProt; NX_Q7L985; -.
DR OpenTargets; ENSG00000174482; -.
DR PharmGKB; PA162394096; -.
DR VEuPathDB; HostDB:ENSG00000174482; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000156665; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; Q7L985; -.
DR OMA; QELHMVG; -.
DR OrthoDB; 399926at2759; -.
DR PhylomeDB; Q7L985; -.
DR TreeFam; TF334360; -.
DR PathwayCommons; Q7L985; -.
DR SignaLink; Q7L985; -.
DR BioGRID-ORCS; 158038; 14 hits in 1070 CRISPR screens.
DR ChiTaRS; LINGO2; human.
DR GenomeRNAi; 158038; -.
DR Pharos; Q7L985; Tbio.
DR PRO; PR:Q7L985; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q7L985; protein.
DR Bgee; ENSG00000174482; Expressed in secondary oocyte and 121 other tissues.
DR Genevisible; Q7L985; HS.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 11.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..606
FT /note="Leucine-rich repeat and immunoglobulin-like domain-
FT containing nogo receptor-interacting protein 2"
FT /id="PRO_0000324389"
FT TOPO_DOM 28..545
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 567..606
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 28..57
FT /note="LRRNT"
FT REPEAT 58..79
FT /note="LRR 1"
FT REPEAT 82..103
FT /note="LRR 2"
FT REPEAT 106..127
FT /note="LRR 3"
FT REPEAT 130..151
FT /note="LRR 4"
FT REPEAT 154..175
FT /note="LRR 5"
FT REPEAT 178..199
FT /note="LRR 6"
FT REPEAT 202..223
FT /note="LRR 7"
FT REPEAT 226..247
FT /note="LRR 8"
FT REPEAT 250..271
FT /note="LRR 9"
FT REPEAT 274..295
FT /note="LRR 10"
FT REPEAT 298..319
FT /note="LRR 11"
FT REPEAT 322..343
FT /note="LRR 12"
FT DOMAIN 355..409
FT /note="LRRCT"
FT DOMAIN 410..499
FT /note="Ig-like C2-type"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 279
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 327
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 432..483
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 507
FT /note="R -> H (in dbSNP:rs17506843)"
FT /id="VAR_039798"
FT CONFLICT 89
FT /note="S -> G (in Ref. 2; BAF83661)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 68066 MW; CB608E281B066B9D CRC64;
MLHTAISCWQ PFLGLAVVLI FMGSTIGCPA RCECSAQNKS VSCHRRRLIA IPEGIPIETK
ILDLSKNRLK SVNPEEFISY PLLEEIDLSD NIIANVEPGA FNNLFNLRSL RLKGNRLKLV
PLGVFTGLSN LTKLDISENK IVILLDYMFQ DLHNLKSLEV GDNDLVYISH RAFSGLLSLE
QLTLEKCNLT AVPTEALSHL RSLISLHLKH LNINNMPVYA FKRLFHLKHL EIDYWPLLDM
MPANSLYGLN LTSLSVTNTN LSTVPFLAFK HLVYLTHLNL SYNPISTIEA GMFSDLIRLQ
ELHIVGAQLR TIEPHSFQGL RFLRVLNVSQ NLLETLEENV FSSPRALEVL SINNNPLACD
CRLLWILQRQ PTLQFGGQQP MCAGPDTIRE RSFKDFHSTA LSFYFTCKKP KIREKKLQHL
LVDEGQTVQL ECSADGDPQP VISWVTPRRR FITTKSNGRA TVLGDGTLEI RFAQDQDSGM
YVCIASNAAG NDTFTASLTV KGFASDRFLY ANRTPMYMTD SNDTISNGTN ANTFSLDLKT
ILVSTAMGCF TFLGVVLFCF LLLFVWSRGK GKHKNSIDLE YVPRKNNGAV VEGEVAGPRR
FNMKMI
