LIGO2_MOUSE
ID LIGO2_MOUSE Reviewed; 606 AA.
AC Q3URE9; Q8BLC0; Q8BZD4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2;
DE AltName: Full=Leucine-rich repeat neuronal protein 6C;
DE Flags: Precursor;
GN Name=Lingo2; Synonyms=Lrrn6c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AK035778; BAC29183.1; -; mRNA.
DR EMBL; AK045639; BAC32442.1; -; mRNA.
DR EMBL; AK141568; BAE24739.1; -; mRNA.
DR EMBL; BC090619; AAH90619.1; -; mRNA.
DR EMBL; BC145692; AAI45693.1; -; mRNA.
DR CCDS; CCDS18040.1; -.
DR RefSeq; NP_001159471.1; NM_001165999.1.
DR RefSeq; NP_001159472.1; NM_001166000.1.
DR RefSeq; NP_001159473.1; NM_001166001.1.
DR RefSeq; NP_780725.2; NM_175516.4.
DR RefSeq; XP_006537965.1; XM_006537902.2.
DR RefSeq; XP_006537966.1; XM_006537903.2.
DR RefSeq; XP_006537967.1; XM_006537904.3.
DR RefSeq; XP_011248319.1; XM_011250017.2.
DR RefSeq; XP_011248320.1; XM_011250018.2.
DR RefSeq; XP_011248321.1; XM_011250019.2.
DR RefSeq; XP_011248322.1; XM_011250020.2.
DR RefSeq; XP_011248324.1; XM_011250022.2.
DR RefSeq; XP_011248325.1; XM_011250023.2.
DR RefSeq; XP_011248327.1; XM_011250025.2.
DR RefSeq; XP_011248328.1; XM_011250026.2.
DR RefSeq; XP_017175684.1; XM_017320195.1.
DR RefSeq; XP_017175685.1; XM_017320196.1.
DR RefSeq; XP_017175686.1; XM_017320197.1.
DR RefSeq; XP_017175687.1; XM_017320198.1.
DR AlphaFoldDB; Q3URE9; -.
DR SMR; Q3URE9; -.
DR STRING; 10090.ENSMUSP00000069772; -.
DR GlyConnect; 2466; 1 N-Linked glycan (1 site).
DR GlyGen; Q3URE9; 10 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q3URE9; -.
DR PhosphoSitePlus; Q3URE9; -.
DR MaxQB; Q3URE9; -.
DR PaxDb; Q3URE9; -.
DR PRIDE; Q3URE9; -.
DR ProteomicsDB; 292253; -.
DR ABCD; Q3URE9; 17 sequenced antibodies.
DR Antibodypedia; 3035; 149 antibodies from 23 providers.
DR DNASU; 242384; -.
DR Ensembl; ENSMUST00000065173; ENSMUSP00000069772; ENSMUSG00000045083.
DR Ensembl; ENSMUST00000098151; ENSMUSP00000095754; ENSMUSG00000045083.
DR Ensembl; ENSMUST00000108122; ENSMUSP00000103757; ENSMUSG00000045083.
DR Ensembl; ENSMUST00000108124; ENSMUSP00000103759; ENSMUSG00000045083.
DR Ensembl; ENSMUST00000164772; ENSMUSP00000130423; ENSMUSG00000045083.
DR GeneID; 242384; -.
DR KEGG; mmu:242384; -.
DR UCSC; uc008sgz.2; mouse.
DR CTD; 158038; -.
DR MGI; MGI:2442298; Lingo2.
DR VEuPathDB; HostDB:ENSMUSG00000045083; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000156665; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; Q3URE9; -.
DR OMA; QELHMVG; -.
DR OrthoDB; 399926at2759; -.
DR PhylomeDB; Q3URE9; -.
DR TreeFam; TF334360; -.
DR BioGRID-ORCS; 242384; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Lingo2; mouse.
DR PRO; PR:Q3URE9; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q3URE9; protein.
DR Bgee; ENSMUSG00000045083; Expressed in animal zygote and 65 other tissues.
DR ExpressionAtlas; Q3URE9; baseline and differential.
DR Genevisible; Q3URE9; MM.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 11.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..606
FT /note="Leucine-rich repeat and immunoglobulin-like domain-
FT containing nogo receptor-interacting protein 2"
FT /id="PRO_0000324390"
FT TOPO_DOM 28..545
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 567..606
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 28..57
FT /note="LRRNT"
FT REPEAT 58..79
FT /note="LRR 1"
FT REPEAT 82..103
FT /note="LRR 2"
FT REPEAT 106..127
FT /note="LRR 3"
FT REPEAT 130..151
FT /note="LRR 4"
FT REPEAT 154..175
FT /note="LRR 5"
FT REPEAT 178..199
FT /note="LRR 6"
FT REPEAT 202..223
FT /note="LRR 7"
FT REPEAT 226..247
FT /note="LRR 8"
FT REPEAT 250..271
FT /note="LRR 9"
FT REPEAT 274..295
FT /note="LRR 10"
FT REPEAT 298..319
FT /note="LRR 11"
FT REPEAT 322..343
FT /note="LRR 12"
FT DOMAIN 355..409
FT /note="LRRCT"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 250
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 260
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 279
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 327
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 491
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 522
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 527
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 432..483
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 537
FT /note="D -> G (in Ref. 1; BAC32442)"
FT /evidence="ECO:0000305"
FT CONFLICT 550
FT /note="F -> Y (in Ref. 1; BAC29183)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 68069 MW; 4E0930B9E948AE33 CRC64;
MLHTAIPCWQ PFLGLAVVLL LMGSTIGCPA RCECSAQNKS VSCHRRRLLA IPEGIPIETK
ILDLSKNRLK SINPEEFISY PLLEEIDLSD NIIANVEPGA FNNLFNLRSL RLKGNRLKLV
PLGVFTGLSN LTKLDISENK IVILLDYMFQ DLHNLKSLEV GDNDLVYISH RAFSGLLSLE
QLTLEKCNLT AVPTEALSHL RSLIALHLKH LNINNMPVYA FKRLFHLKNL EIDYWPLLDL
MPANSLYGLN LTSLSITNTN LSTVPFLAFK HLVYLTHLNL SYNPISTIEA GMFSDLIRLQ
ELHIVGAQLR TIEPHSFQGL RFLRVLNVSQ NLLETLEENV FSSPRALEVL SINNNPLACD
CRLLWLLQRQ PNLQFGGQQP MCAGPDTIRE RSFKDFHSTA LSFYFTCKKP KIREKKLQHL
LVDEGQTVQL ECNADGDPQP VISWVTPRRR FITTKSNGRA TVLGDGTLEI RFAQDQDSGM
YVCIASNAAG NDTFTASLTV KGFTSDRFLY ANRTPMYMTD SNDTVSNGTN ANTFSLDLKT
ILVSTAMGCF TFLGVVLFCF LLLFVWSRGK GKHKNSIDLE YVPRKNNGAV VEGEVAGPRR
FNMKMI
