LIGO3_HUMAN
ID LIGO3_HUMAN Reviewed; 592 AA.
AC P0C6S8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3;
DE AltName: Full=Leucine-rich repeat neuronal protein 2;
DE AltName: Full=Leucine-rich repeat neuronal protein 6B;
DE Flags: Precursor;
GN Name=LINGO3; Synonyms=LERN2, LRRN6B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=14686891; DOI=10.1111/j.1460-9568.2003.03003.x;
RA Carim-Todd L., Escarceller M., Estivill X., Sumoy L.;
RT "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with
RT enriched expression in limbic system and neocortex.";
RL Eur. J. Neurosci. 18:3167-3182(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AC004152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45905.1; -.
DR RefSeq; NP_001094861.1; NM_001101391.1.
DR AlphaFoldDB; P0C6S8; -.
DR SMR; P0C6S8; -.
DR STRING; 9606.ENSP00000467753; -.
DR GlyGen; P0C6S8; 9 sites, 1 O-linked glycan (1 site).
DR PhosphoSitePlus; P0C6S8; -.
DR BioMuta; LINGO3; -.
DR DMDM; 182662399; -.
DR MassIVE; P0C6S8; -.
DR PaxDb; P0C6S8; -.
DR PeptideAtlas; P0C6S8; -.
DR PRIDE; P0C6S8; -.
DR ProteomicsDB; 52330; -.
DR Antibodypedia; 64907; 73 antibodies from 14 providers.
DR DNASU; 645191; -.
DR Ensembl; ENST00000585527.1; ENSP00000467753.2; ENSG00000220008.3.
DR GeneID; 645191; -.
DR KEGG; hsa:645191; -.
DR UCSC; uc060rka.1; human.
DR CTD; 645191; -.
DR GeneCards; LINGO3; -.
DR HGNC; HGNC:21206; LINGO3.
DR HPA; ENSG00000220008; Tissue enriched (brain).
DR MIM; 609792; gene.
DR neXtProt; NX_P0C6S8; -.
DR OpenTargets; ENSG00000220008; -.
DR PharmGKB; PA162394097; -.
DR VEuPathDB; HostDB:ENSG00000220008; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000162661; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; P0C6S8; -.
DR OMA; CECAPQL; -.
DR OrthoDB; 399926at2759; -.
DR PhylomeDB; P0C6S8; -.
DR TreeFam; TF334360; -.
DR PathwayCommons; P0C6S8; -.
DR SignaLink; P0C6S8; -.
DR BioGRID-ORCS; 645191; 13 hits in 1064 CRISPR screens.
DR GenomeRNAi; 645191; -.
DR Pharos; P0C6S8; Tdark.
DR PRO; PR:P0C6S8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P0C6S8; protein.
DR Bgee; ENSG00000220008; Expressed in nucleus accumbens and 81 other tissues.
DR Genevisible; P0C6S8; HS.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 7.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..592
FT /note="Leucine-rich repeat and immunoglobulin-like domain-
FT containing nogo receptor-interacting protein 3"
FT /id="PRO_0000326529"
FT TOPO_DOM 25..531
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 532..552
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 553..592
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 25..54
FT /note="LRRNT"
FT REPEAT 55..76
FT /note="LRR 1"
FT REPEAT 79..100
FT /note="LRR 2"
FT REPEAT 103..124
FT /note="LRR 3"
FT REPEAT 127..148
FT /note="LRR 4"
FT REPEAT 151..172
FT /note="LRR 5"
FT REPEAT 175..196
FT /note="LRR 6"
FT REPEAT 207..228
FT /note="LRR 7"
FT REPEAT 247..268
FT /note="LRR 8"
FT REPEAT 271..292
FT /note="LRR 9"
FT REPEAT 295..316
FT /note="LRR 10"
FT REPEAT 319..340
FT /note="LRR 11"
FT DOMAIN 352..406
FT /note="LRRCT"
FT DOMAIN 407..496
FT /note="Ig-like C2-type"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 247
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 488
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 512
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 429..480
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 426
FT /note="R -> H (in dbSNP:rs7258841)"
FT /id="VAR_059395"
SQ SEQUENCE 592 AA; 64881 MW; 54C12AD313CE1414 CRC64;
MTCWLCVLSL PLLLLPAAPP PAGGCPARCE CTVQTRAVAC TRRRLTAVPD GIPAETRLLE
LSRNRIRCLN PGDLAALPAL EELDLSENAI AHVEPGAFAN LPRLRVLRLR GNQLKLIPPG
VFTRLDNLTL LDLSENKLVI LLDYTFQDLH SLRRLEVGDN DLVFVSRRAF AGLLALEELT
LERCNLTALS GESLGHLRSL GALRLRHLAI ASLEDQNFRR LPGLLHLEID NWPLLEEVAA
GSLRGLNLTS LSVTHTNITA VPAAALRHQA HLTCLNLSHN PISTVPRGSF RDLVRLRELH
LAGALLAVVE PQAFLGLRQI RLLNLSNNLL STLEESTFHS VNTLETLRVD GNPLACDCRL
LWIVQRRKTL NFDGRLPACA TPAEVRGDAL RNLPDSVLFE YFVCRKPKIR ERRLQRVTAT
AGEDVRFLCR AEGEPAPTVA WVTPQHRPVT ATSAGRARVL PGGTLEIQDA RPQDSGTYTC
VASNAGGNDT YFATLTVRPE PAANRTPGEA HNETLAALRA PLDLTTILVS TAMGCITFLG
VVLFCFVLLF VWSRGRGQHK NNFSVEYSFR KVDGPAAAAG QGGARKFNMK MI
