LIGO3_MOUSE
ID LIGO3_MOUSE Reviewed; 589 AA.
AC Q6GQU6; E9QK50;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3;
DE AltName: Full=Leucine-rich repeat neuronal protein 6B;
DE Flags: Precursor;
GN Name=Lingo3; Synonyms=Lrrn6b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AC166937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC072620; AAH72620.1; -; mRNA.
DR CCDS; CCDS24035.1; -.
DR RefSeq; NP_001013780.2; NM_001013758.2.
DR RefSeq; XP_006513683.1; XM_006513620.3.
DR RefSeq; XP_006513684.1; XM_006513621.3.
DR RefSeq; XP_006513685.1; XM_006513622.3.
DR RefSeq; XP_006513686.1; XM_006513623.2.
DR AlphaFoldDB; Q6GQU6; -.
DR SMR; Q6GQU6; -.
DR STRING; 10090.ENSMUSP00000054960; -.
DR GlyConnect; 2467; 3 N-Linked glycans (2 sites).
DR GlyGen; Q6GQU6; 8 sites, 3 N-linked glycans (2 sites).
DR iPTMnet; Q6GQU6; -.
DR PhosphoSitePlus; Q6GQU6; -.
DR PaxDb; Q6GQU6; -.
DR PeptideAtlas; Q6GQU6; -.
DR PRIDE; Q6GQU6; -.
DR ProteomicsDB; 252474; -.
DR Antibodypedia; 64907; 73 antibodies from 14 providers.
DR Ensembl; ENSMUST00000053986; ENSMUSP00000054960; ENSMUSG00000051067.
DR GeneID; 237403; -.
DR KEGG; mmu:237403; -.
DR UCSC; uc007gey.3; mouse.
DR CTD; 645191; -.
DR MGI; MGI:3609246; Lingo3.
DR VEuPathDB; HostDB:ENSMUSG00000051067; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000162661; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; Q6GQU6; -.
DR OMA; CECAPQL; -.
DR OrthoDB; 399926at2759; -.
DR PhylomeDB; Q6GQU6; -.
DR TreeFam; TF334360; -.
DR BioGRID-ORCS; 237403; 8 hits in 73 CRISPR screens.
DR PRO; PR:Q6GQU6; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q6GQU6; protein.
DR Bgee; ENSMUSG00000051067; Expressed in retinal neural layer and 94 other tissues.
DR ExpressionAtlas; Q6GQU6; baseline and differential.
DR Genevisible; Q6GQU6; MM.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 8.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..589
FT /note="Leucine-rich repeat and immunoglobulin-like domain-
FT containing nogo receptor-interacting protein 3"
FT /id="PRO_0000326530"
FT TOPO_DOM 24..528
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 529..549
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 550..589
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 24..53
FT /note="LRRNT"
FT REPEAT 54..75
FT /note="LRR 1"
FT REPEAT 78..99
FT /note="LRR 2"
FT REPEAT 102..123
FT /note="LRR 3"
FT REPEAT 126..147
FT /note="LRR 4"
FT REPEAT 150..171
FT /note="LRR 5"
FT REPEAT 174..195
FT /note="LRR 6"
FT REPEAT 206..227
FT /note="LRR 7"
FT REPEAT 246..267
FT /note="LRR 8"
FT REPEAT 270..291
FT /note="LRR 9"
FT REPEAT 294..315
FT /note="LRR 10"
FT REPEAT 318..339
FT /note="LRR 11"
FT DOMAIN 351..405
FT /note="LRRCT"
FT DOMAIN 406..495
FT /note="Ig-like C2-type"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 246
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 275
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 323
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 487
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 501
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 509
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 428..479
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 76
FT /note="L -> F (in Ref. 2; AAH72620)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 589 AA; 64683 MW; CD0E38941EE7B47A CRC64;
MTCWLHMLGL HLLLLPTAPL AAGCPARCEC SASTRTVACG RRRLTAIPEG IPAETRMLEL
SRNRIRCLNP GDLASLPTLE ELDLNHNVIA HVEPGAFANL PRLRVLRLRG NQLKLIPPGV
FTHLDSLTLL DLSENKLVIL LDFSFQDLRS LQRLEVGDND LVFISRRAFA GLLGLAELTL
ERCNLTSLSP ESLGHLRGLG ALRLRHLAIA ALEDQNFQKL PGLSHLEIDN WPLLEEVAPG
SLRGLNLTSL SITHTNITAV PAAALRQQAH LTCLNLSHNP ISMVPRGSFR DLVRLRELHL
AGALLAVIEP QAFVGLRQIR LLNLSDNLLS TLEENTFHSV NTLETLRVDG NPLACDCRLL
WIVQRRKTLN FDGRLPACAT PAEVRGDALH NLPDSVLFEY FVCRKPKIRE RRLQHVTATE
GDDVRFLCRA EGEPAPTVAW VTPQHHSVTA ASRGRARVLP GGTLTIADTR PQDSGTYTCV
ASNAGGNDTY FATLTVQPAA NRTQGDGHNE TQVGVRFPLD LTTILVSTAM GCITFLGVVL
FCFLLLFVWS RGRGQHKNNF SVEYSFRKVD GPAAAAGQGG ARKFNMKMI
