LIGO4_MOUSE
ID LIGO4_MOUSE Reviewed; 593 AA.
AC Q149C3; A0A4X2;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4;
DE AltName: Full=Leucine-rich repeat neuronal protein 6D;
DE Flags: Precursor;
GN Name=Lingo4; Synonyms=Lrrn6d;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-401.
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI17867.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI17868.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC31214.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BC117866; AAI17867.1; ALT_INIT; mRNA.
DR EMBL; BC117867; AAI17868.1; ALT_INIT; mRNA.
DR EMBL; AK042286; BAC31214.1; ALT_FRAME; mRNA.
DR CCDS; CCDS17592.1; -.
DR RefSeq; NP_796224.1; NM_177250.2.
DR AlphaFoldDB; Q149C3; -.
DR SMR; Q149C3; -.
DR BioGRID; 236263; 1.
DR STRING; 10090.ENSMUSP00000058050; -.
DR GlyGen; Q149C3; 6 sites.
DR iPTMnet; Q149C3; -.
DR PhosphoSitePlus; Q149C3; -.
DR PaxDb; Q149C3; -.
DR PRIDE; Q149C3; -.
DR ProteomicsDB; 252475; -.
DR DNASU; 320747; -.
DR GeneID; 320747; -.
DR KEGG; mmu:320747; -.
DR UCSC; uc008qgb.1; mouse.
DR CTD; 339398; -.
DR MGI; MGI:2444651; Lingo4.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; Q149C3; -.
DR OrthoDB; 428840at2759; -.
DR PhylomeDB; Q149C3; -.
DR TreeFam; TF334360; -.
DR BioGRID-ORCS; 320747; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q149C3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q149C3; protein.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 8.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..593
FT /note="Leucine-rich repeat and immunoglobulin-like domain
FT containing-NOGO receptor-interacting protein 4"
FT /id="PRO_0000324185"
FT TOPO_DOM 30..533
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 534..554
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 555..593
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..60
FT /note="LRRNT"
FT REPEAT 61..82
FT /note="LRR 1"
FT REPEAT 85..106
FT /note="LRR 2"
FT REPEAT 109..130
FT /note="LRR 3"
FT REPEAT 133..154
FT /note="LRR 4"
FT REPEAT 157..178
FT /note="LRR 5"
FT REPEAT 181..202
FT /note="LRR 6"
FT REPEAT 210..231
FT /note="LRR 7"
FT REPEAT 253..274
FT /note="LRR 8"
FT REPEAT 277..298
FT /note="LRR 9"
FT REPEAT 301..322
FT /note="LRR 10"
FT REPEAT 325..346
FT /note="LRR 11"
FT DOMAIN 358..412
FT /note="LRRCT"
FT DOMAIN 412..502
FT /note="Ig-like C2-type"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 253
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 263
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 492
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 508
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 515
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 435..484
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 593 AA; 64189 MW; CCF153432BE07A5B CRC64;
MDAATAPKQA WLPWSPLLFL LLLPGGSISS CPTVCDCTSQ TRAVFCAHRR LDTIPGGLPL
DTELLDLSGN RLWGLQRGML SRLGQLQELD LSYNQLSTLE PGAFHGLQSL LTLRLQGNRL
RIVGPGIFSG LTALTLLDLR LNQIVLFLDG AFSELGSLQQ LEVGDNHLVF VAPGAFAGLA
KLSTITLERC NLSTVPGLAL AQLPALVALR LRELDIERLP AGALRGLGQL KELEIHHWPS
LEALDPGSLV GLNLSSLAIT RCNLSSVPFQ ALHHLSFLRI LDLSQNPISA IPARRLSPLV
RLQELRLSGA CLTSIAAHAF HGLTAFHLLD VADNALQTLE ETAFPSPDKL VTLRLSGNPL
TCDCRLLWLL RLRRRLDFGT SPPACAGPQH VQGKSLREFS DILPPGHFTC KPALIRKSGP
RWVIAEEGGH AVFSCSGDGD PAPTVSWMRP QGAWLGRVGR VRVLEDGTLE IRSVQLRDRG
AYVCVVSNVA GNDSLRTWLE VIQVEPPNGT LSDPNITMPG IPGPFFLDSR GVAMVLAVGF
LPFLTSVTLC FGLIALWSKG KGRVKHHMTF DFVAPRPSGD KNSGGNRVTA KLF
