LIG_AEDAE
ID LIG_AEDAE Reviewed; 1250 AA.
AC Q16VD3; Q16VC9; Q16VD0; Q16VD1; Q16VD2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Protein lingerer;
GN Name=lig {ECO:0000250|UniProtKB:Q86S05}; ORFNames=AAEL009607;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000312|EMBL:EAT38502.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Acts in the nervous system to mediate the control of
CC copulatory organs during courtship. {ECO:0000250|UniProtKB:Q86S05}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86S05}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=A {ECO:0000269|PubMed:17510324};
CC IsoId=Q16VD3-1; Sequence=Displayed;
CC Name=B {ECO:0000269|PubMed:17510324};
CC IsoId=Q16VD3-2; Sequence=VSP_052636, VSP_052638;
CC Name=C {ECO:0000269|PubMed:17510324};
CC IsoId=Q16VD3-3; Sequence=VSP_052636;
CC Name=D {ECO:0000269|PubMed:17510324};
CC IsoId=Q16VD3-4; Sequence=VSP_052635, VSP_052636;
CC Name=E {ECO:0000269|PubMed:17510324};
CC IsoId=Q16VD3-5; Sequence=VSP_052636, VSP_052637;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH477597; EAT38499.1; -; Genomic_DNA.
DR EMBL; CH477597; EAT38500.1; -; Genomic_DNA.
DR EMBL; CH477597; EAT38501.1; -; Genomic_DNA.
DR EMBL; CH477597; EAT38502.1; -; Genomic_DNA.
DR EMBL; CH477597; EAT38503.1; -; Genomic_DNA.
DR RefSeq; XP_001653854.1; XM_001653804.1.
DR RefSeq; XP_001653855.1; XM_001653805.1.
DR RefSeq; XP_001653856.1; XM_001653806.1.
DR RefSeq; XP_001653857.1; XM_001653807.1.
DR RefSeq; XP_001653858.1; XM_001653808.1.
DR AlphaFoldDB; Q16VD3; -.
DR SMR; Q16VD3; -.
DR STRING; 7159.AAEL009607-PE; -.
DR PRIDE; Q16VD3; -.
DR VEuPathDB; VectorBase:AAEL009607; -.
DR eggNOG; ENOG502QPRH; Eukaryota.
DR HOGENOM; CLU_005969_0_0_1; -.
DR InParanoid; Q16VD3; -.
DR OMA; PPYNIAG; -.
DR OrthoDB; 689121at2759; -.
DR PhylomeDB; Q16VD3; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0007620; P:copulation; ISS:UniProtKB.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR022166; UBAP2/Lig.
DR Pfam; PF12478; DUF3697; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Behavior; Cytoplasm; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1250
FT /note="Protein lingerer"
FT /id="PRO_0000314619"
FT DOMAIN 107..147
FT /note="UBA"
FT /evidence="ECO:0000255"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 812
FT /note="Missing (in isoform D)"
FT /evidence="ECO:0000303|PubMed:17510324"
FT /id="VSP_052635"
FT VAR_SEQ 921..939
FT /note="SMSSPSLGLTNTKVTNSTA -> T (in isoform B, isoform C,
FT isoform D and isoform E)"
FT /evidence="ECO:0000303|PubMed:17510324"
FT /id="VSP_052636"
FT VAR_SEQ 1218
FT /note="Q -> QMDNRTYNSGSGVMR (in isoform E)"
FT /evidence="ECO:0000303|PubMed:17510324"
FT /id="VSP_052637"
FT VAR_SEQ 1219..1250
FT /note="DSNSSGQRPQSNSQGKTATKQGYSPSYWTGQN -> V (in isoform
FT B)"
FT /evidence="ECO:0000303|PubMed:17510324"
FT /id="VSP_052638"
SQ SEQUENCE 1250 AA; 131545 MW; 1AD19FE9F376E209 CRC64;
MSTQTRSGGG GGGRNKSKAS KENKENAGMD EQPQPQLQQQ KGNATVNSGG GEKQKKGIDN
SGSKGGDSKD KQHQQTTTHT IKTKQPTAEQ IRIAQITDIK SGMDDPKIQE KIQKLMETTQ
RSEEEVCCAL QECDNDLDRA VIFLLETLPV GAFATTSKKK KNKSQNKEQN DSATGDGDWD
NGGNVGSGSG GGGGLSADSK DRRGNRPGNQ RSGGGPGGPG SRGGRGGFRD GERGGDRDRN
GFDRGGRGPR GRDGRDGGPG RGSYGGGSRG GRGGGPRVGT RGPGMRESNR APRITDHQEI
DVWDSVATPS ANDLNKPEES SAFADTWGDW DNEEYTGSLS DTKVFTPSTQ VAATTPPAQQ
QQQQPTSSST QSQPTSQPQQ PTTPQPVQSQ IAPVQPATVS SSVTSLEQQI LNPLQPKETD
LVQQYSTTVV SSTATAAAAA TVQYPDLHSA PSAAQHLRQA LEMPQINNSS SSLSAEQSQY
FNTLSSQNSN LQSSVVNSYQ QSSVQYPTSY GSSSTYSDQV TSSQQAPTAR RQRARVPPPS
KIPSSAVEMP GDSLNNIGYL DVQFGGLDFG TDDTFDSVPV TDKFNTNSLE QSTPSSVQLP
SAVQPTQSEV NDYQSKPSVV NNLQQKSSLT SSLQSTQILP GQSDALTATQ SDSLSNSYSQ
RNTSTVVPSS VSSGVNVNSI NSTTSTLEQL TKTDPYSQST GTNAGSGGYQ NVSYSTSQAN
KTSSYPSSAA PQGYNNSSYS STQVSTNTYP ASSNNYSSYN QSGVNSYQQP SSNVSSSVVP
NNNSTSSVGV STVNQSNPNL PVNNNVSNNS SSNTNTGYLS SQYPVSQTSS AFPSQQSYQN
SSQNVYGNTG LNSNTGYSGS TSTSSGQYSN FSSSKLKDTP VSTQFDSVSS STVSNNNSAN
NNSVSSSSSS LPNSSVVSTT SMSSPSLGLT NTKVTNSTAK SSSSSGTGVV PNIPMVSPYI
QPGVPFYQQP LYSYEDLQML QQRMSHVPGY YDMNYQTPTS LGAAGVRDAN LGSVAYSTMS
DGRFTRTDNN SSPVSNVPST MSQQTGSGGP MLNLPYAYFY GGNVMPGGFQ YGTPAVYPPQ
PMATNATSGG QFQKPAYNSG YGTSGYDTLS QSGQDYNKNP YPSSGVGQQS KGQTVSNQQS
AGGSGSDIAP SMYGKSHVAL NKVNSYEKQS FHSGTPPPYN IAGTQTAGAT SGQPYGQHLY
IPQIPTHHNI NMHQAMHQDS NSSGQRPQSN SQGKTATKQG YSPSYWTGQN
