LIG_DROPS
ID LIG_DROPS Reviewed; 1327 AA.
AC Q290X3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 3.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Protein lingerer;
GN Name=lig {ECO:0000250|UniProtKB:Q86S05}; ORFNames=GA21277;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Acts in the nervous system to mediate the control of
CC copulatory organs during courtship. {ECO:0000250|UniProtKB:Q86S05}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86S05}.
CC Note=Found in the cytoplasm of many neuronal and glial cells in the
CC brain and ventral ganglion, and in imaginal disks.
CC {ECO:0000250|UniProtKB:Q86S05}.
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DR EMBL; CM000071; EAL25239.2; -; Genomic_DNA.
DR AlphaFoldDB; Q290X3; -.
DR SMR; Q290X3; -.
DR STRING; 7237.FBpp0277686; -.
DR eggNOG; ENOG502QPRH; Eukaryota.
DR HOGENOM; CLU_005969_0_0_1; -.
DR InParanoid; Q290X3; -.
DR OMA; PPYNIAG; -.
DR ChiTaRS; lig; fly.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0007620; P:copulation; ISS:UniProtKB.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR022166; UBAP2/Lig.
DR Pfam; PF12478; DUF3697; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
PE 3: Inferred from homology;
KW Behavior; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..1327
FT /note="Protein lingerer"
FT /id="PRO_0000314622"
FT DOMAIN 80..120
FT /note="UBA"
FT /evidence="ECO:0000255"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1236..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1294..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 656
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 657
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1327 AA; 133811 MW; 3C3D3C6B39E74FC5 CRC64;
MSTQTRSGGG GGGGGNSRSQ KKSNSANVGG GTAHDAAPHA AANKKGDANK TDKPEKAQPK
ATTEQLRIAQ ITNSTTEDPQ INEKVTLLLT MTQRSEEEVC CALNECDYDL EAAANFLIEE
LPQGAFAKYE KKRKRPASTA ADGAAGDGEW ADGNANADKR ENTRNRSSNR GGGRGGTDSR
GWRGRETREN ERNTRESRGG GGERGGERGD DRANDNYRGQ RNGGRSAPGG GGGRGGGFVS
RSGRGGGRMG GRSSGPRGDR TSGSGGFGAG RSSNANEDHH EVELWDNTIA QNAEKQQPGH
DDSWGDWNNE EYEGSLKDSK VFTTSNLSTQ TAAAVVSGGG AAAGAASSTG SGGELSAPPG
LEHHLGSMGT TGEDNSGSSG PPATPPSALS GSATTPLLQY SAAVSNPPPQ MQSQGTQHSS
GGGTAAGGGG SASSSFVSAA SDTFTSAASA AATLVQQAQQ QQQLQQTTPI KPSATLSVEQ
SQYFNSLASQ GVSPGSTAVQ PTPAGYAPSS ATAYSQTSTS VGGGGGVGGS TYPSTYANVF
GSTAGDQSQQ QTQVRRARVK LPPPSKIPAT AVEMPGDNAL NNIGYLDVQF GALDFGTDDS
FDSMPEKFNA SVEQQQQQQD DYQSKSQQQQ QSTLTAGLQS SQIGDALSAA GYAARSTAQQ
QQQSASSTVA SNALDQLTKN DPYGQASSAS SAYQNAYQSS AASKANSAYQ TSAQGSYSSS
SYANVQSSVA NSYQQQGYGS YQPNVNSYQQ QQTVAGTQPS VGGVVPGSGS ASTQNIPVGG
SASQNSSSGN ASSAYLTSGY STPQSAYQSS QSVYGNSSGF AGSASNASSQ YASFGTSAKL
KDASTASGAA HYDSVSTSSG VSSSSGSTGN GAAGAVSGQP GVNQASVSNN NNVSGSSSNS
NVTAGVTSGN VAGGGVSQSG VSSGGVGVAG GSGSASSVGV NVNNNNAGSV GGAAVAAQTA
AGTAAVLASL TNKNSSSSNS SGSGVGGGAT TAGGVGGAST GSGVGAGSGA GSGGGGGSGS
GLVPTNIQMV SQYIQTGLPY YQQPVYSYEE LQMMQQRVPH VQGYYDLNYT PTSLGAGRDN
LGSVAYSTMT DGRFARTDNN SSPVSNVSST MSQQAGSSAP MLNVPYAYFY GGNVMPGGFQ
YGTPAIYPQQ IPTANTASGG QFPKPSYSAG YGSTNYDTLS QTTQDYSKGG YSTSVNQQTK
TQTVSNQPQA GTASDLTSSM YGKGHVALNK VNSYEKQSFH SGTPPPFNMA NTQTAGGTSA
QPYGMYLPMP AAGHHNMIHQ PIHQMDGRIH SSSRRDSNSA GQRQQSSSQS KSAGKQGYSP
SYWTGQN
