ID   LIIP2_ARATH             Reviewed;         333 AA.
AC   F4KFD8; Q9FIB5;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Small GTPase-like protein LIP2 {ECO:0000303|PubMed:17683937};
GN   Name=LIP2 {ECO:0000303|PubMed:17683937};
GN   OrderedLocusNames=At5g09910 {ECO:0000312|Araport:AT5G09910};
GN   ORFNames=MYH9.12 {ECO:0000312|EMBL:BAB09412.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA   Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT   features of the regions of 1,081,958 bp covered by seventeen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:379-391(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=17683937; DOI=10.1016/j.cub.2007.07.018;
RA   Kevei E., Gyula P., Feher B., Toth R., Viczian A., Kircher S., Rea D.,
RA   Dorjgotov D., Schaefer E., Millar A.J., Kozma-Bognar L., Nagy F.;
RT   "Arabidopsis thaliana circadian clock is regulated by the small GTPase
RT   LIP1.";
RL   Curr. Biol. 17:1456-1464(2007).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB09412.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB016893; BAB09412.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED91466.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM69029.1; -; Genomic_DNA.
DR   RefSeq; NP_001318521.1; NM_001343075.1.
DR   RefSeq; NP_196553.2; NM_121028.4.
DR   AlphaFoldDB; F4KFD8; -.
DR   SMR; F4KFD8; -.
DR   STRING; 3702.AT5G09910.1; -.
DR   iPTMnet; F4KFD8; -.
DR   PaxDb; F4KFD8; -.
DR   PRIDE; F4KFD8; -.
DR   ProteomicsDB; 238420; -.
DR   EnsemblPlants; AT5G09910.1; AT5G09910.1; AT5G09910.
DR   EnsemblPlants; AT5G09910.4; AT5G09910.4; AT5G09910.
DR   GeneID; 830852; -.
DR   Gramene; AT5G09910.1; AT5G09910.1; AT5G09910.
DR   Gramene; AT5G09910.4; AT5G09910.4; AT5G09910.
DR   KEGG; ath:AT5G09910; -.
DR   Araport; AT5G09910; -.
DR   TAIR; locus:2178148; AT5G09910.
DR   eggNOG; ENOG502QT3S; Eukaryota.
DR   HOGENOM; CLU_061105_0_0_1; -.
DR   InParanoid; F4KFD8; -.
DR   OMA; PRRTIGC; -.
DR   OrthoDB; 1269342at2759; -.
DR   PRO; PR:F4KFD8; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4KFD8; baseline and differential.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..333
FT                   /note="Small GTPase-like protein LIP2"
FT                   /id="PRO_0000438815"
FT   REGION          11..288
FT                   /note="Small GTPase-like"
FT                   /evidence="ECO:0000305"
FT   REGION          242..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..256
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         29..36
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C5J9"
FT   BINDING         90..94
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C5J9"
FT   BINDING         160..163
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C5J9"
SQ   SEQUENCE   333 AA;  36893 MW;  CBFB28EFD667F28A CRC64;
     MRFWRERGRE NKEHMVAPLC GQIRVLVVGD SGVGKSSLVH LIVKGSSIVR PSQTIGCTVG
     VKHLTYASPA SSSSIIKGDS ERDFFVELWD VSGHERYKDC RSLFYSQING VIFVHDLSQR
     TTKTNLQKWA GEVSVTGEFS APLSSGGPGG LPVPYIVIGN KADIAAKGGT NGSSGNLVDA
     ARHWVEKQGL LPHSDELPLS ESFPSNVGLI MAAKEARYDK EALTKIFHML IRRRYFSDEL
     PSPSSAWSLS HAPSQRLDEG TSDEDQFYKR TSLREGDAYK YNTLPQHNLM QSPTLYPQQP
     PDRYNYAIPR FSLSSVEETS NGNGRSKRMD INV