LIMA_DICDI
ID LIMA_DICDI Reviewed; 1183 AA.
AC Q54QR1; P90533;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=LIM domain-containing protein A;
GN Name=limA; ORFNames=DDB_G0283599;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 561-1183.
RC STRAIN=AX4;
RA Iranfar N., Loomis W.F.;
RT "Dictyostelium discoideum LimA (limA) mRNA.";
RL Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AAFI02000056; EAL65566.1; -; Genomic_DNA.
DR EMBL; U83086; AAB40929.1; -; mRNA.
DR RefSeq; XP_638962.1; XM_633870.1.
DR AlphaFoldDB; Q54QR1; -.
DR STRING; 44689.DDB0191181; -.
DR PaxDb; Q54QR1; -.
DR PRIDE; Q54QR1; -.
DR EnsemblProtists; EAL65566; EAL65566; DDB_G0283599.
DR GeneID; 8624208; -.
DR KEGG; ddi:DDB_G0283599; -.
DR dictyBase; DDB_G0283599; limA.
DR eggNOG; KOG1044; Eukaryota.
DR HOGENOM; CLU_272783_0_0_1; -.
DR InParanoid; Q54QR1; -.
DR OMA; DARHEIM; -.
DR PRO; PR:Q54QR1; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 3.
DR SMART; SM00132; LIM; 4.
DR PROSITE; PS00478; LIM_DOMAIN_1; 4.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 2: Evidence at transcript level;
KW LIM domain; Metal-binding; Reference proteome; Repeat; Zinc.
FT CHAIN 1..1183
FT /note="LIM domain-containing protein A"
FT /id="PRO_0000328164"
FT DOMAIN 3..61
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 982..1043
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 1052..1117
FT /note="LIM zinc-binding 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 1118..1179
FT /note="LIM zinc-binding 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT REGION 56..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..537
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..590
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..736
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..923
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..945
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 570
FT /note="K -> I (in Ref. 2; AAB40929)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1183 AA; 132913 MW; 9EFF9BAFDB1E110F CRC64;
MLFICRKCNT RVEGETIFVF GYHYHPNCFV CVSCNCSLSD VYFEIDKLPY CELDYKKPRP
GDPTNVPVLK KKPFSKPVDA SNLPRTWNNS VKPTNNNNIN NNNSNNSNNN NNNNNNNNNN
NNSNLNNTTN NSNNNNNNNS KPNYNPLTSF GSNNLKKSTS VENNLKSSNG ISSGGGSGSG
SGSGSGNPEL MYMEKNGADQ QSIPVVLDST NKNNNNNNNN SNNNNNSNNN NNSNDSDNKQ
TPVNVYSASI ENQIIEPKHG SLINDGNNST KSKSNSNTGV PNNSTQYNAT PSPSSEVVNQ
FVVVESDKGQ NPTNAKRSNS FGDSLDDIIS SMEMIPKNNV STGSNVFNIQ DDEKFKEIQL
KKHNENNNNN NNNNNNNNNN NNNNYNYNNN NNGENNQNNS NKKQPHIGGG ENLDEQVDIK
INKCNEVNDS YQPSKPSVAI YSSNNNNNLK PGNIAYGNNS QSSDPSEPVV IGDHRSNSPR
TKSQLDLNQY QPTPNVGKST QPTTTTTTTT TTSTTKTLPN KDNDNHLHGH DHQNDDNNNS
SSDSSDSEDD SVHDSSSSSE DESDHERKRK ARKEKKKQQK QLKHRQGHHI HNHEVGGGGA
AVVIDNDNEN PDDKSKSKKG GLHLDVDFTF GKKEHHHQQQ KEHDDDAEEE QAKVKYVDKG
VQAGSDLSIS NPSGTMIVED IHTAKLKEND HHAHPNPLEH SHPHQSHSHS HSHSHPQHPH
SHPQHPHSHP HQSHSHSHAH SQPTTTVQPQ QQQQHSLSTV VHPHNATPSH HHHHQHSHSQ
PHSFDHNQHQ HQPLQHHHHT HSQPISIQHQ HIENKHIDSP IQHHVSHNIK NSHHQHQHQH
PSHSDEPIVQ QHVQETTKTT TTQYKPPQSS IQNNNNNNNN LIIEDSTHHS HNLHNNNGRD
GIKSYSKTFI TDDPNYHQNQ NQNQHHSHQH HSHQHHSHQH HHHQHQPYQQ QQQQIKVDSL
PPQRPKEKVY TQTITTIVSS GKNCKRCKLE IFGNTLINHL QETYHPECFK CSNCFSSIVD
PYFTEPSTNK IFCAKCQIVL NDLAKPKRDS LGFCCSCYKF LTEEDDIIVI DKEKYHNKCF
KCSSCKEVIR GNNFSREQMT STSSNYCCNT CLHSGRVDKC AYCHGVILGV SMLAMGQNYH
PKCFKCSTCH VVIRHNTPFT INKNQTPTCQ NCINTSSVGV ASR
