ID   LIMD1_XENLA             Reviewed;         612 AA.
AC   Q06BR1;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=LIM domain-containing protein 1;
GN   Name=limd1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH SNAI1.
RX   PubMed=18331720; DOI=10.1016/j.devcel.2008.01.005;
RA   Langer E.M., Feng Y., Zhaoyuan H., Rauscher F.J. III, Kroll K.L.,
RA   Longmore G.D.;
RT   "Ajuba LIM proteins are snail/slug corepressors required for neural crest
RT   development in Xenopus.";
RL   Dev. Cell 14:424-436(2008).
CC   -!- FUNCTION: Acts as a transcriptional corepressor for snai1 and
CC       snai2/slug and plays a role in regulating neural crest development.
CC       {ECO:0000269|PubMed:18331720}.
CC   -!- SUBUNIT: Interacts with snai1. {ECO:0000269|PubMed:18331720}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the zyxin/ajuba family. {ECO:0000305}.
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DR   EMBL; DQ913740; ABI84194.1; -; mRNA.
DR   RefSeq; NP_001090194.1; NM_001096725.1.
DR   AlphaFoldDB; Q06BR1; -.
DR   BioGRID; 607792; 1.
DR   IntAct; Q06BR1; 1.
DR   GeneID; 779085; -.
DR   KEGG; xla:779085; -.
DR   CTD; 779085; -.
DR   Xenbase; XB-GENE-1017241; limd1.L.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 779085; Expressed in spleen and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003714; F:transcription corepressor activity; IMP:UniProtKB.
DR   GO; GO:0014032; P:neural crest cell development; IMP:UniProtKB.
DR   InterPro; IPR028734; LIMD1.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24219:SF3; PTHR24219:SF3; 1.
DR   Pfam; PF00412; LIM; 3.
DR   SMART; SM00132; LIM; 3.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 3.
PE   1: Evidence at protein level;
KW   Cytoplasm; LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..612
FT                   /note="LIM domain-containing protein 1"
FT                   /id="PRO_0000416962"
FT   DOMAIN          414..475
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          479..539
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          540..608
FT                   /note="LIM zinc-binding 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ   SEQUENCE   612 AA;  68332 MW;  884777069F6CFCB3 CRC64;
     MDTYDELSLE ASKFIQDLTL YEASKDGLFR VDKGLSNNPE FEETKRIFAA KMAKIHLQNQ
     QKSIPDTGIS EGNGLTHQYN YSLPKSVEEG PVIYNGLSNS SVGPSDYKTY RESYKGKPDI
     DSADRSEESV FKHDSEIMLP SPLGKVGNTI PTQQFTSKKA ISPSIESLER ERTIKNNITG
     FENYRLCNSS SMKNCKPHQN SRHGEVEDTM AENFTENKTP FKQCSALISS SVTFGDDTHT
     NIPQKKLFNL PSTSSINTQN NSDDVYLSKT NAAKEFHGEQ RGLCSTNSLG FGNPNDVISA
     SYCVGYNDNF PGEIKQKQSP HYTFHSGHSS VDEQPQAIPF CCKDSSGQGP ASTIDSDHTD
     ILQDSSALMK IKLPCQTLSQ SSKQGSSKAE KKLEAITRHV EQEMDAHNKA DYFGTCVKCS
     KGVYGASQAC QAMGNLYHNG CFICSACSRK LRGKAFYFVN GKVYCEEDFL YSGFHQSADR
     CFVCGHWIMD MILQALGKSF HPGCFRCVVC NECLDGVPFT VDMENKIYCV KDYHKILAPK
     CAVCSLPILP SEGTDETIRV VSMDKDYHID CYRCECCALE LNNEDDHRCY PLDGHLFCHN
     CHLKYLENHN LS