ID   LIMD1_XENTR             Reviewed;         593 AA.
AC   B7ZUL2; Q28I83;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=LIM domain-containing protein 1;
GN   Name=limd1; ORFNames=TEgg075f13;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional corepressor for snai1 and
CC       snai2/slug and plays a role in regulating neural crest development.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with snai1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the zyxin/ajuba family. {ECO:0000305}.
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DR   EMBL; CR760537; CAJ81256.1; -; mRNA.
DR   EMBL; BC171270; AAI71270.1; -; mRNA.
DR   RefSeq; NP_001016606.1; NM_001016606.2.
DR   RefSeq; XP_012820161.1; XM_012964707.2.
DR   RefSeq; XP_012820162.1; XM_012964708.2.
DR   RefSeq; XP_012820163.1; XM_012964709.2.
DR   AlphaFoldDB; B7ZUL2; -.
DR   STRING; 8364.ENSXETP00000058624; -.
DR   PaxDb; B7ZUL2; -.
DR   GeneID; 549360; -.
DR   KEGG; xtr:549360; -.
DR   CTD; 8994; -.
DR   Xenbase; XB-GENE-1017238; limd1.
DR   eggNOG; KOG1701; Eukaryota.
DR   InParanoid; B7ZUL2; -.
DR   OrthoDB; 326249at2759; -.
DR   Reactome; R-XTR-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000031781; Expressed in egg cell and 11 other tissues.
DR   GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
DR   GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0035331; P:negative regulation of hippo signaling; IBA:GO_Central.
DR   GO; GO:0014032; P:neural crest cell development; ISS:UniProtKB.
DR   GO; GO:2000637; P:positive regulation of miRNA-mediated gene silencing; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IBA:GO_Central.
DR   InterPro; IPR028734; LIMD1.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24219:SF3; PTHR24219:SF3; 1.
DR   Pfam; PF00412; LIM; 3.
DR   SMART; SM00132; LIM; 3.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 3.
PE   2: Evidence at transcript level;
KW   Cytoplasm; LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..593
FT                   /note="LIM domain-containing protein 1"
FT                   /id="PRO_0000416963"
FT   DOMAIN          395..456
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          460..520
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          521..589
FT                   /note="LIM zinc-binding 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   REGION          308..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        137
FT                   /note="T -> I (in Ref. 1; CAJ81256)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   593 AA;  66160 MW;  DB6C66661085965E CRC64;
     MDTYEELSLE ASKFIQDLTL YEASKDGLFR VDKGASNNPE FEETKRIFAA KMAKIHLQNQ
     QKNIPDTGTS EGNGSNLQYT YSMPKSVEEV PVTYNGQSSS SVGQSDYKTY RESYKVKPEI
     DSADSSEEPV IRHEHETMLL SPVSKVGHAI PSQQFTCKKA ISPSNESLER ERIGSENMHS
     DLNLSSMINC KPMEKNTPHN KCSPLISSSV IFGEETNTHI PQQKFFNLSS PSSINLQKTS
     DHVCLSETKA AKEFNGEQRG FCSTNSLNSG SSNDVKLSAL SSYCVGYNEN SSDQIKQMQA
     PCYTFNSGHS SADEQPQEIP FSCTDSSAEP PASTLDSDHI DIVQDSSTLM KIKLPCQTLS
     QSSKQGSSRA EKKLEAITRH LEQEMDAHTR ADYFGTCVKC SKGVYGANQA CQAMGNLYHN
     GCFICSACSR KLRGKAFYFV NGKVYCEEDF LYSGFHQSAD RCFVCGHWIM DMILQALGKS
     FHPGCFRCAV CNECLDGVPF TVDMENKIYC VKDYHKILAP KCAACSLPIL PSEGTDETIR
     VVSMDKDYHI DCYRCESCAL ELNNEDDHRC YPLEGHLFCH NCHLKYLENH NLS