LIMS3_HUMAN
ID LIMS3_HUMAN Reviewed; 117 AA.
AC P0CW19; A0A0A6YYD2; B4DPH6; Q9HB10;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=LIM and senescent cell antigen-like-containing domain protein 3;
DE AltName: Full=Particularly interesting new Cys-His protein 3;
DE Short=PINCH-3;
GN Name=LIMS3; Synonyms=PINCH3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RA Sha J.H., Li J.M., Zhou Z.M.;
RT "A new pinch protein of human testis.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Brain;
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P0CW19-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P0CW19-2; Sequence=VSP_054392;
CC -!- TISSUE SPECIFICITY: Detected in testis. {ECO:0000269|Ref.1}.
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DR EMBL; AF288404; AAF99328.1; -; mRNA.
DR EMBL; AK298340; BAG60588.1; -; mRNA.
DR EMBL; AK316210; BAH14581.1; -; mRNA.
DR EMBL; AC013271; AAY14903.1; -; Genomic_DNA.
DR EMBL; AC108938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC093812; AAH93812.1; -; mRNA.
DR EMBL; BC112233; AAI12234.1; -; mRNA.
DR CCDS; CCDS2084.1; -. [P0CW19-1]
DR RefSeq; NP_001192217.1; NM_001205288.1. [P0CW19-1]
DR RefSeq; NP_277049.1; NM_033514.4. [P0CW19-1]
DR AlphaFoldDB; P0CW19; -.
DR BMRB; P0CW19; -.
DR SMR; P0CW19; -.
DR BioGRID; 125178; 12.
DR BioGRID; 940351; 11.
DR STRING; 9606.ENSP00000404432; -.
DR iPTMnet; P0CW19; -.
DR PhosphoSitePlus; P0CW19; -.
DR BioMuta; LIMS3; -.
DR DMDM; 334350997; -.
DR jPOST; P0CW19; -.
DR MassIVE; P0CW19; -.
DR MaxQB; P0CW19; -.
DR PaxDb; P0CW19; -.
DR PeptideAtlas; P0CW19; -.
DR PRIDE; P0CW19; -.
DR ProteomicsDB; 4785; -.
DR Antibodypedia; 66681; 80 antibodies from 12 providers.
DR DNASU; 96626; -.
DR Ensembl; ENST00000437679.3; ENSP00000405165.2; ENSG00000256977.13. [P0CW19-1]
DR Ensembl; ENST00000631420.1; ENSP00000488227.1; ENSG00000256977.13. [P0CW19-2]
DR GeneID; 100288695; -.
DR GeneID; 96626; -.
DR KEGG; hsa:100288695; -.
DR KEGG; hsa:96626; -.
DR CTD; 100288695; -.
DR CTD; 96626; -.
DR DisGeNET; 100288695; -.
DR DisGeNET; 96626; -.
DR GeneCards; LIMS3; -.
DR HGNC; HGNC:30047; LIMS3.
DR HPA; ENSG00000256977; Tissue enhanced (endometrium, fallopian tube).
DR neXtProt; NX_P0CW19; -.
DR OpenTargets; ENSG00000257207; -.
DR PharmGKB; PA134917873; -.
DR VEuPathDB; HostDB:ENSG00000256977; -.
DR eggNOG; KOG2272; Eukaryota.
DR GeneTree; ENSGT00940000153518; -.
DR HOGENOM; CLU_2084116_0_0_1; -.
DR InParanoid; P0CW19; -.
DR OMA; SSIRTCH; -.
DR TreeFam; TF314113; -.
DR PathwayCommons; P0CW19; -.
DR SignaLink; P0CW19; -.
DR SIGNOR; P0CW19; -.
DR BioGRID-ORCS; 100288695; 114 hits in 617 CRISPR screens.
DR BioGRID-ORCS; 96626; 214 hits in 902 CRISPR screens.
DR Pharos; P0CW19; Tbio.
DR PRO; PR:P0CW19; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P0CW19; protein.
DR Bgee; ENSG00000256977; Expressed in endometrium and 100 other tissues.
DR ExpressionAtlas; P0CW19; baseline and differential.
DR Genevisible; P0CW19; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR017351; PINCH_1-like.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24210; PTHR24210; 1.
DR Pfam; PF00412; LIM; 1.
DR SMART; SM00132; LIM; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; LIM domain; Metal-binding;
KW Reference proteome; Zinc.
FT CHAIN 1..117
FT /note="LIM and senescent cell antigen-like-containing
FT domain protein 3"
FT /id="PRO_0000266013"
FT DOMAIN 70..117
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT VAR_SEQ 115..117
FT /note="ERT -> FEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRC
FT DLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHP
FT DHFNCANCGQEGSDCRCTGAERGAILPAMP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054392"
SQ SEQUENCE 117 AA; 13251 MW; F260926C06DA51CE CRC64;
MAFSGRARPC IIPENEEIPR AALNTVHEAN GTEDERAVSK LQRRHSDVKV YKEFCDFYAK
FNMANALASA TCERCKGGFA PAETIVNSNG ELYHEQCFVC AQCFQQFPEG LFYEERT
