LIMS4_HUMAN
ID LIMS4_HUMAN Reviewed; 117 AA.
AC P0CW20; C9K0W2;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=LIM and senescent cell antigen-like-containing domain protein 4;
DE AltName: Full=LIM and senescent cell antigen-like-containing domain protein 3-like;
GN Name=LIMS4 {ECO:0000312|HGNC:HGNC:39941}; Synonyms=LIMS3L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- INTERACTION:
CC P0CW20; Q03989: ARID5A; NbExp=3; IntAct=EBI-10196832, EBI-948603;
CC P0CW20; P41182: BCL6; NbExp=6; IntAct=EBI-10196832, EBI-765407;
CC P0CW20; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-10196832, EBI-12809220;
CC P0CW20; O43186: CRX; NbExp=3; IntAct=EBI-10196832, EBI-748171;
CC P0CW20; Q8IW50-3: FAM219A; NbExp=3; IntAct=EBI-10196832, EBI-13358054;
CC P0CW20; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-10196832, EBI-745707;
CC P0CW20; Q96G42: KLHDC7B; NbExp=3; IntAct=EBI-10196832, EBI-9478422;
CC P0CW20; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10196832, EBI-1052037;
CC P0CW20; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-10196832, EBI-6257312;
CC P0CW20; P0CI26: TRIM49C; NbExp=3; IntAct=EBI-10196832, EBI-12889036;
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DR EMBL; AC108938; AAY24131.1; -; Genomic_DNA.
DR EMBL; AC112229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS54387.1; -.
DR RefSeq; NP_001192217.1; NM_001205288.1.
DR RefSeq; NP_277049.1; NM_033514.4.
DR AlphaFoldDB; P0CW20; -.
DR BMRB; P0CW20; -.
DR SMR; P0CW20; -.
DR BioGRID; 125178; 12.
DR BioGRID; 940351; 11.
DR IntAct; P0CW20; 10.
DR iPTMnet; P0CW20; -.
DR PhosphoSitePlus; P0CW20; -.
DR BioMuta; LIMS4; -.
DR DMDM; 334350996; -.
DR jPOST; P0CW20; -.
DR MassIVE; P0CW20; -.
DR MaxQB; P0CW20; -.
DR PRIDE; P0CW20; -.
DR Antibodypedia; 77119; 16 antibodies from 3 providers.
DR DNASU; 96626; -.
DR Ensembl; ENST00000413601.3; ENSP00000404432.2; ENSG00000256671.7.
DR GeneID; 100288695; -.
DR GeneID; 96626; -.
DR KEGG; hsa:100288695; -.
DR KEGG; hsa:96626; -.
DR UCSC; uc002tff.4; human.
DR CTD; 100288695; -.
DR CTD; 96626; -.
DR DisGeNET; 100288695; -.
DR DisGeNET; 96626; -.
DR GeneCards; LIMS4; -.
DR HGNC; HGNC:39941; LIMS4.
DR HPA; ENSG00000256671; Not detected.
DR neXtProt; NX_P0CW20; -.
DR VEuPathDB; HostDB:ENSG00000256671; -.
DR GeneTree; ENSGT00940000153518; -.
DR HOGENOM; CLU_2084116_0_0_1; -.
DR InParanoid; P0CW20; -.
DR OrthoDB; 292981at2759; -.
DR PathwayCommons; P0CW20; -.
DR SignaLink; P0CW20; -.
DR SIGNOR; P0CW20; -.
DR BioGRID-ORCS; 100288695; 114 hits in 617 CRISPR screens.
DR BioGRID-ORCS; 96626; 214 hits in 902 CRISPR screens.
DR ChiTaRS; LIMS4; human.
DR Pharos; P0CW20; Tdark.
DR PRO; PR:P0CW20; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P0CW20; protein.
DR Bgee; ENSG00000256671; Expressed in descending thoracic aorta and 93 other tissues.
DR ExpressionAtlas; P0CW20; baseline.
DR Genevisible; P0CW20; HS.
DR GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR017351; PINCH_1-like.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24210; PTHR24210; 1.
DR Pfam; PF00412; LIM; 1.
DR SMART; SM00132; LIM; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE 1: Evidence at protein level;
KW LIM domain; Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..117
FT /note="LIM and senescent cell antigen-like-containing
FT domain protein 4"
FT /id="PRO_0000409553"
FT DOMAIN 70..117
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ SEQUENCE 117 AA; 13251 MW; F260926C06DA51CE CRC64;
MAFSGRARPC IIPENEEIPR AALNTVHEAN GTEDERAVSK LQRRHSDVKV YKEFCDFYAK
FNMANALASA TCERCKGGFA PAETIVNSNG ELYHEQCFVC AQCFQQFPEG LFYEERT
