ID   LIN14_CAEBR             Reviewed;         543 AA.
AC   Q9GNL2; A8XQU4; Q9GNL0; Q9GNL1;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Protein lin-14;
DE   AltName: Full=Abnormal cell lineage protein 14;
GN   Name=lin-14; ORFNames=CBG17326;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A; B1 AND B2).
RX   PubMed=11139502; DOI=10.1093/genetics/157.1.199;
RA   Reinhart B.J., Ruvkun G.;
RT   "Isoform-specific mutations in the Caenorhabditis elegans heterochronic
RT   gene lin-14 affect stage-specific patterning.";
RL   Genetics 157:199-209(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Heterochronic protein which controls the choice of stage
CC       specific cell fates. Involved in the temporal progression of vulval
CC       fate patterning, possibly by inhibiting lin-12. Acts as a transcription
CC       factor involved in the stage-specific repression of insulin/insulin-
CC       like growth factor gene ins-33. {ECO:0000250|UniProtKB:Q21446}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q21446}. Note=May
CC       associate with mitotic chromosomes. {ECO:0000250|UniProtKB:Q21446}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=B1;
CC         IsoId=Q9GNL2-1; Sequence=Displayed;
CC       Name=A;
CC         IsoId=Q9GNL2-2; Sequence=VSP_012680;
CC       Name=B2;
CC         IsoId=Q9GNL2-3; Sequence=VSP_012681;
CC   -!- PTM: Cleaved by caspase ced-3 in vitro. {ECO:0000250|UniProtKB:Q21446}.
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DR   EMBL; AF304863; AAG41199.1; -; Genomic_DNA.
DR   EMBL; AF304862; AAG41199.1; JOINED; Genomic_DNA.
DR   EMBL; AF304863; AAG41200.1; -; Genomic_DNA.
DR   EMBL; AF304860; AAG41200.1; JOINED; Genomic_DNA.
DR   EMBL; AF304861; AAG41200.1; JOINED; Genomic_DNA.
DR   EMBL; AF304862; AAG41200.1; JOINED; Genomic_DNA.
DR   EMBL; AF304863; AAG41201.1; -; Genomic_DNA.
DR   EMBL; AF304861; AAG41201.1; JOINED; Genomic_DNA.
DR   EMBL; AF304862; AAG41201.1; JOINED; Genomic_DNA.
DR   EMBL; HE600924; CAP35019.1; -; Genomic_DNA.
DR   RefSeq; XP_002643961.1; XM_002643915.1. [Q9GNL2-1]
DR   AlphaFoldDB; Q9GNL2; -.
DR   SMR; Q9GNL2; -.
DR   STRING; 6238.CBG17326; -.
DR   EnsemblMetazoa; CBG17326b.1; CBG17326b.1; WBGene00036988. [Q9GNL2-1]
DR   GeneID; 8585954; -.
DR   KEGG; cbr:CBG_17326; -.
DR   CTD; 8585954; -.
DR   WormBase; CBG17326a; CBP43403; WBGene00036988; Cbr-lin-14.
DR   eggNOG; ENOG502S18Y; Eukaryota.
DR   HOGENOM; CLU_520958_0_0_1; -.
DR   InParanoid; Q9GNL2; -.
DR   OMA; PIFPFPQ; -.
DR   OrthoDB; 796674at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Alternative splicing; Developmental protein; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..543
FT                   /note="Protein lin-14"
FT                   /id="PRO_0000084424"
FT   REGION          165..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          268..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..64
FT                   /note="MGKGQPIEPNIEQSLVDLCKRTVAMNLLHCYPTTTEHELSCEEWGNGTERSQ
FT                   SMAACQGCVELR -> MDLPGTSTSDEFLQHFASFNFNSPTSPVGQQHPGIMPTLQAMY
FT                   PTLIQVPDLKGDYLMRSDISAF (in isoform A)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_012680"
FT   VAR_SEQ         1..24
FT                   /note="Missing (in isoform B2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_012681"
SQ   SEQUENCE   543 AA;  60099 MW;  96D4B87381E73057 CRC64;
     MGKGQPIEPN IEQSLVDLCK RTVAMNLLHC YPTTTEHELS CEEWGNGTER SQSMAACQGC
     VELRKEVHDL RTAVNLILPM LPLYPQLPNT FTTAANIAAQ PALHQVLQQS LLRRKPTAHT
     PTVPQPECPG QLRTVLSSPG SALPNVMLMN HLMINGLKPV SPTLPNGHIQ PAVGEASMQT
     DEQQVKWSSP SSVDSNGQKT DSSAASAGDN QNIDVIGDGS ESPTSSNHSV QELAMLTSHQ
     NLFNAFKDSQ FIFNQVPKQE PVAPLRVAPA TNGTTNGATK AAGPERKPRK PVNDDIVKIV
     RNQDLSEENI ATFQIPVPKA HLSDPTFRPV SEQQIIQQII QGKKYDEMEV GETMIQLCKK
     LAEKRVFGPR LMSQTTVAGL NHSNYSNLPI KGICYIQHVC RKVLYDKFEN EEDFWDKFRE
     AMRKLAARCR RVRHAKKTKH NREEAQAEML SKRYGEDIPF NLNGSGLIIP KSEPSETPAV
     NGDINMITMG QIGTLLTQFN ADRKTPLTEV LPAELLTTFL SYLNRPKQEV QSPPPAQNPQ
     NPN