LIN1_YEAST
ID LIN1_YEAST Reviewed; 340 AA.
AC P38852; D3DLA5;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Protein LIN1;
GN Name=LIN1; OrderedLocusNames=YHR156C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH IRR1; PRP8; HEX3; NFI1; WSS1;
RP RFC1 AND YJL149W.
RX PubMed=12402242; DOI=10.1002/yea.919;
RA Bialkowska A., Kurlandzka A.;
RT "Proteins interacting with Lin 1p, a putative link between chromosome
RT segregation, mRNA splicing and DNA replication in Saccharomyces
RT cerevisiae.";
RL Yeast 19:1323-1333(2002).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- SUBUNIT: Interacts with the cohesin subunit IRR1. Interacts with PRP8,
CC HEX3, NFI1, WSS1, RFC1 and YJL149W. {ECO:0000269|PubMed:12402242}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12402242}.
CC Note=Probably associated with chromatin.
CC -!- MISCELLANEOUS: Present with 799 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the LIN1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U10397; AAB68990.1; -; Genomic_DNA.
DR EMBL; AY557881; AAS56207.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06849.1; -; Genomic_DNA.
DR PIR; S46768; S46768.
DR RefSeq; NP_012026.1; NM_001179287.1.
DR AlphaFoldDB; P38852; -.
DR BioGRID; 36590; 116.
DR ComplexPortal; CPX-29; U5 small nuclear ribonucleoprotein complex.
DR DIP; DIP-4407N; -.
DR IntAct; P38852; 11.
DR MINT; P38852; -.
DR STRING; 4932.YHR156C; -.
DR MaxQB; P38852; -.
DR PaxDb; P38852; -.
DR PRIDE; P38852; -.
DR EnsemblFungi; YHR156C_mRNA; YHR156C; YHR156C.
DR GeneID; 856561; -.
DR KEGG; sce:YHR156C; -.
DR SGD; S000001199; LIN1.
DR VEuPathDB; FungiDB:YHR156C; -.
DR eggNOG; KOG2950; Eukaryota.
DR HOGENOM; CLU_065846_1_0_1; -.
DR InParanoid; P38852; -.
DR OMA; WMNDVIN; -.
DR BioCyc; YEAST:G3O-31191-MON; -.
DR PRO; PR:P38852; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38852; protein.
DR GO; GO:0000785; C:chromatin; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0005681; C:spliceosomal complex; IC:ComplexPortal.
DR GO; GO:0005682; C:U5 snRNP; IDA:SGD.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IC:ComplexPortal.
DR Gene3D; 3.30.1490.40; -; 1.
DR InterPro; IPR039905; CD2BP2/Lin1.
DR InterPro; IPR003169; GYF.
DR InterPro; IPR035445; GYF-like_dom_sf.
DR PANTHER; PTHR13138; PTHR13138; 1.
DR Pfam; PF02213; GYF; 1.
DR SMART; SM00444; GYF; 1.
DR SUPFAM; SSF55277; SSF55277; 1.
DR PROSITE; PS50829; GYF; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..340
FT /note="Protein LIN1"
FT /id="PRO_0000195038"
FT DOMAIN 282..340
FT /note="GYF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00101"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 40369 MW; 59A10D63E0C8715C CRC64;
MKYTQYPNSS KLKRNSDRRE HDEKLSDELH NQSTIYEDEE LSRAEYDSDS DSSVEDSTDN
ENSGKEMDEK SYEKNEDHVE DHRKRKKSKI QLLDIAEFKK ENLADLDYQI GNSESKVEKG
VNIEPFNIDD EIKHGVFDKD GNYIKTENAT ENDQQDNEEW MNDVINTEEV NRLEKEQSVK
TQNSRHYMVH EALNLLKFFL VDENETVLES LGRLNKLRKI AISKKNKSLK YVIHGIELLS
DLINILEKKG FSEVYEYNRL KVQDAIEEEI FDDSSRIVNH KTKLWGFKWL NKLDEYHGLY
TNYEMSYWQK SYFKNSVIVK FHSEPDRDEN WIHVSCLSFM
