ID   LIN25_CAEBR             Reviewed;        1142 AA.
AC   Q9GNN7;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein lin-25;
DE   AltName: Full=Abnormal cell lineage protein 25;
GN   Name=lin-25 {ECO:0000312|EMBL:AAG17638.1}; ORFNames=CBG08546;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:AAG17638.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11063686; DOI=10.1093/genetics/156.3.1083;
RA   Nilsson L., Tiensuu T., Tuck S.;
RT   "Caenorhabditis elegans lin-25: a study of its role in multiple cell fate
RT   specification events involving ras and the identification and
RT   characterization of evolutionarily conserved domains.";
RL   Genetics 156:1083-1096(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Participates in the inductive signaling pathway downstream of
CC       let-60 Ras and the RAF/MAP kinase cascade to regulate specification and
CC       differentiation of many cell types. Positively regulates the fate of
CC       vulval precursor cells. Required for induction of the P12 and excretory
CC       duct cell fates. In males, it is also required for proper formation of
CC       spicules. Does not function in the signaling pathway that promotes exit
CC       from pachytene (By similarity). {ECO:0000250|UniProtKB:Q10573}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q10573}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q10573}.
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DR   EMBL; AF263434; AAG17638.1; -; mRNA.
DR   EMBL; HE601197; CAP28468.3; -; Genomic_DNA.
DR   RefSeq; XP_002636261.1; XM_002636215.1.
DR   AlphaFoldDB; Q9GNN7; -.
DR   STRING; 6238.CBG08546; -.
DR   EnsemblMetazoa; CBG08546.1; CBG08546.1; WBGene00030313.
DR   GeneID; 8578256; -.
DR   KEGG; cbr:CBG_08546; -.
DR   CTD; 8578256; -.
DR   WormBase; CBG08546; CBP02128; WBGene00030313; Cbr-lin-25.
DR   eggNOG; ENOG502S9A0; Eukaryota.
DR   HOGENOM; CLU_301410_0_0_1; -.
DR   InParanoid; Q9GNN7; -.
DR   OMA; HCPLPRI; -.
DR   OrthoDB; 1236368at2759; -.
DR   Proteomes; UP000008549; Chromosome V.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0001708; P:cell fate specification; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:EnsemblMetazoa.
DR   GO; GO:0040025; P:vulval development; IEA:EnsemblMetazoa.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..1142
FT                   /note="Protein lin-25"
FT                   /id="PRO_0000338449"
FT   REGION          600..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        600..614
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        633..664
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..704
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1142 AA;  131215 MW;  2316F7E6D6662A46 CRC64;
     MHIAVDNLTI SVPKIDKPTK AALDYVELLR ESFSAKKRQK FSKASLAIRP SDFPDLSNQQ
     LCDILVRVAY NGSHIDEDFR KHVLDLVEDQ SLTWNQVLLS VIRTQSDQLY MKSQLCELIT
     EMIRFVQIKS FHDPKHADSL ISVILPTFVF LTKLILELLS DEDEMETIQI EYETKFPPYH
     KPLQALNTLI HDNLCGPLLA MYRSSEEVTR QLVLCSEAFS KLERPDESSV GLLDLILEKH
     QDNCKPTKYE YTPDGLAAYD LKNPSVRILV PIFACFRCHE TSKQMAETVQ IFVDIMRVSG
     DDVVFDLLHA AILLKCEESN NLLHLSKQHR LDFRWQSTTF FYKKLPQIIE HLVSFGKVTA
     EDVQKGMERA LNDLTMLFDV ADISWQNASF LTVLNALEPL IGSEAANPLR HRRREYMRKT
     ASLTALADSD EKLIENTDID RLLNAVKQVM NLQFGQNEEF YQEFIRKVNG DDCEDFDAVM
     SILISEGRLL EVGKAFAMKS KLAQYPSELS LDERIKKFDE TFLLLTRIIV KFPGLSIGLL
     VNGGPGEISI ADSIFYRWSM WYVKRVPRKD KSEEKSEEEL EAMRIQAKVL IEEINKEVGI
     EEEIEEEEED IEPEVVKEMK ESGTEKEKEE EEEDGNKETK NETANDEEMP GDEQKTEEKM
     DTSETPAEPP IQQQSTPEDP PKVEEPAERI NQEKPEEKPK EPLEPTWNEM NCALPRISRK
     KARRYLGLLK QGNPFWSTDN NSLNIGAILA ALPSMGKLLI EEHNEEKHRV DRKSAEEHMA
     NIIHALESMP CLFVCLVQWV DCAPASPART LLAKTMKNAL EKRVSSSSAS IADDTNLPKW
     RFILSTCNEM IHELTDRVPV FPDITCTAFS AARRLCPFVT RDEIPDSTKL KHAWYYMCQQ
     SWTSPHALRL LEHANIHSEY NTWIHLYITK IVGGGCGEIM KDQVDMIFGM LMMDDLNVII
     RMHEIMMDFW LSEEAGNLQL DGRFDPLSMT AVIRLMANVM LISEWTLDRL INDGPPLVEF
     DFTSAMTPEP EDPLRREKWV FLLRQMLDRT VNRLFKILRQ GVLCTVVNTI VRLIKAIAGS
     ADCKAKRLLI KRIPPEIVFQ LAYIEPQCAD YALMNAYCDP KNEEHTRTKI RFLCALRRSH
     IL