LIN31_CAEEL
ID LIN31_CAEEL Reviewed; 237 AA.
AC P34683;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Protein lin-31;
DE AltName: Full=Abnormal cell lineage protein 31;
GN Name=lin-31; ORFNames=K10G6.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=8504934; DOI=10.1101/gad.7.6.933;
RA Miller L.M., Gallegos M.E., Morisseau B.A., Kim S.K.;
RT "lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor
RT homolog, specifies three alternative cell fates in vulval development.";
RL Genes Dev. 7:933-947(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Lin-31 regulates how vulval precursor cells choose their
CC fate. It helps specify three alternative cell fates in vulval
CC development.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; L11148; AAA28104.1; -; Genomic_DNA.
DR EMBL; FO081624; CCD72892.1; -; Genomic_DNA.
DR PIR; A47368; A47368.
DR RefSeq; NP_494704.1; NM_062303.4.
DR AlphaFoldDB; P34683; -.
DR SMR; P34683; -.
DR BioGRID; 39096; 3.
DR IntAct; P34683; 1.
DR MINT; P34683; -.
DR STRING; 6239.K10G6.1; -.
DR PaxDb; P34683; -.
DR EnsemblMetazoa; K10G6.1.1; K10G6.1.1; WBGene00003017.
DR GeneID; 173740; -.
DR KEGG; cel:CELE_K10G6.1; -.
DR UCSC; K10G6.1; c. elegans.
DR CTD; 173740; -.
DR WormBase; K10G6.1; CE12098; WBGene00003017; lin-31.
DR eggNOG; KOG3562; Eukaryota.
DR GeneTree; ENSGT00940000161970; -.
DR HOGENOM; CLU_040357_6_2_1; -.
DR InParanoid; P34683; -.
DR OMA; MAIQDSD; -.
DR OrthoDB; 1270467at2759; -.
DR PRO; PR:P34683; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00003017; Expressed in material anatomical entity and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:WormBase.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0040025; P:vulval development; IMP:WormBase.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..237
FT /note="Protein lin-31"
FT /id="PRO_0000091908"
FT DNA_BIND 12..103
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 110..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 237 AA; 26896 MW; 9C89B362ACD34D4B CRC64;
MPRPGKDSYD EQKPPYSYIW LTYMAIQDSD DKMLPLTEIY KYIMDRFPFY RKNTQRWQNS
LRHNLSFNDC FIKIPRRADR PGKGSYWAVH PNASGMFENG SCLRRRKRFR ARGGQDDDDD
DFHHPAPSKI SRKNPLPLLP EPPITPPLLS SLFPNLPPSL PNFCLFPPGM DPTKSLLLNP
LSLLLMPHFL KNSSNFESST PHSETSEISG SGSSSSKTPT PEAGFNSSFS IESILSS
