LIN36_CAEEL
ID LIN36_CAEEL Reviewed; 962 AA.
AC P34427; Q9U552;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-2002, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Protein lin-36;
DE AltName: Full=Abnormal cell lineage protein 36;
GN Name=lin-36; ORFNames=F44B9.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF ARG-189; GLU-241; PRO-246;
RP HIS-284; GLY-324 AND TYR-325, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=10393123; DOI=10.1242/dev.126.15.3449;
RA Thomas J.H., Horvitz H.R.;
RT "The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb
RT pathway.";
RL Development 126:3449-3459(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required to negatively regulate vulval development.
CC Antagonizes Ras-mediated vulval induction. Acts cell autonomously.
CC {ECO:0000269|PubMed:10393123}.
CC -!- INTERACTION:
CC P34427; P51875: goa-1; NbExp=3; IntAct=EBI-322214, EBI-316062;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10393123}.
CC -!- TISSUE SPECIFICITY: Expressed in vulval precursor P(3-8).p cells and
CC their descendants, neurons of the head, tail and ventral cord,
CC hypodermal and intestinal cells and germline cells.
CC {ECO:0000269|PubMed:10393123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF104917; AAD22772.1; -; mRNA.
DR EMBL; FO080400; CCD63449.1; -; Genomic_DNA.
DR PIR; S44812; S44812.
DR RefSeq; NP_498747.2; NM_066346.4.
DR AlphaFoldDB; P34427; -.
DR BioGRID; 41334; 49.
DR DIP; DIP-26933N; -.
DR IntAct; P34427; 38.
DR MINT; P34427; -.
DR STRING; 6239.F44B9.6; -.
DR iPTMnet; P34427; -.
DR EPD; P34427; -.
DR PaxDb; P34427; -.
DR PeptideAtlas; P34427; -.
DR PRIDE; P34427; -.
DR EnsemblMetazoa; F44B9.6.1; F44B9.6.1; WBGene00003021.
DR GeneID; 176128; -.
DR KEGG; cel:CELE_F44B9.6; -.
DR UCSC; F44B9.6; c. elegans.
DR CTD; 176128; -.
DR WormBase; F44B9.6; CE30992; WBGene00003021; lin-36.
DR eggNOG; ENOG502TG7M; Eukaryota.
DR HOGENOM; CLU_010483_0_0_1; -.
DR InParanoid; P34427; -.
DR OMA; YSNDGAQ; -.
DR OrthoDB; 455065at2759; -.
DR SignaLink; P34427; -.
DR PRO; PR:P34427; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003021; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; IGI:WormBase.
DR InterPro; IPR006612; THAP_Znf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 2.
DR PROSITE; PS50950; ZF_THAP; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..962
FT /note="Protein lin-36"
FT /id="PRO_0000068655"
FT ZN_FING 161..249
FT /note="THAP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 189
FT /note="R->Q: In N772."
FT /evidence="ECO:0000269|PubMed:10393123"
FT MUTAGEN 241
FT /note="E->K: In N747."
FT /evidence="ECO:0000269|PubMed:10393123"
FT MUTAGEN 246
FT /note="P->L: In N750 and N2240."
FT /evidence="ECO:0000269|PubMed:10393123"
FT MUTAGEN 284
FT /note="H->Y: In N3097."
FT /evidence="ECO:0000269|PubMed:10393123"
FT MUTAGEN 324
FT /note="G->E: In N2243."
FT /evidence="ECO:0000269|PubMed:10393123"
FT MUTAGEN 325
FT /note="Y->N: In N3090."
FT /evidence="ECO:0000269|PubMed:10393123"
SQ SEQUENCE 962 AA; 107944 MW; 0822197B43572514 CRC64;
MSEELLSTRP SKRDYNDIEE PEDSHVTVHS VEQDSQHSGE ESSTVDALQE TEGDVDVIGE
DEDEHDIPVM PTVTSSGEVL DESQVTPTKQ ASSSQPREEI IHGKGESVYS SFPCQVIPET
LSRMTRTPPD GEHLEVYRMS NGRLRIYVVD HFKKFSPYSN LTHKPCTVCN RVMKSGEMHL
NFPADLDRRR IWANLLGFKY KDILRSKMGP VSFSIAAGPI CTEHFAEECF RNHNFNKSAI
EAFGVPVAIS PDVKTTPSKK SSRVPWVCTV CEFHSCSVVE LQTHLLNHTE EMLKKKDNVL
DVPEAGFMCP FCRKCTYGYK TISGYRRHLN AGPIHHCHLR RIYEFAKMNC RATELDPAES
WDNWTRRNVY VAYHGCEPPA NEIVLTPSPT KKAYVQNPEE RTKMVHDEEK RKKAVRTLSF
VGKEGGTSVN DLNVMQRQVF LQLRREAEIN TKAEESAQGT KEQESSQKKH AEEESDDVSE
LTSHQSPQAP MGSGERRKAT RLATSATNSP IKKVAKHEVP ATAPSTPAKK RKISHEEEHD
PTPESVEREP TVSPNDPRER LRLKERDEQF AKMVQKRSQQ VKRLINAKQF KKQEAATKKP
RKALAYNLAK GIAATSSTEP EDKVTSSEQT PEPTTSQKFI ARNTRSKTKE SAVQKVEKPA
TPVAKPAPVE KEPEERPLKS MLARSFVAGV RPSMAKYQIP LESFTATASL GGGRSLSSGV
ISRPPTSSSP GGIFSQRVMG AVAQEKGPAK RPSVLSRRPL ILSPRKKTST PRPTLSHHES
SPNFSASSPV VVSDEYLIPA TDMEVEMVEE VIDSMGNSSS EDVATSSTSS ERQPMLTLAE
ALEMDGSSGT VKDQDMEEIS KEMMKDAHYY RAMEDAIKCR TVTKMRADMR LSRHCIRQIE
AARARARLFG ERTEDYQIFY SNDGAQVLTK KDPKWRELQQ QQQQQQQQQE QFPGQGSSDS
QQ
