ID   LIN37_BOVIN             Reviewed;         246 AA.
AC   Q1RMQ5;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Protein lin-37 homolog;
DE   AltName: Full=Antolefinin;
GN   Name=LIN37;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Component of the DREAM complex (also named LINC complex) at
CC       least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2,
CC       RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent
CC       cells where it represses cell cycle-dependent genes. It dissociates in
CC       S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds
CC       to MYBL2 (By similarity). {ECO:0000250}.
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DR   EMBL; BC114775; AAI14776.1; -; mRNA.
DR   RefSeq; NP_001069494.1; NM_001076026.2.
DR   AlphaFoldDB; Q1RMQ5; -.
DR   STRING; 9913.ENSBTAP00000042485; -.
DR   PaxDb; Q1RMQ5; -.
DR   Ensembl; ENSBTAT00000045069; ENSBTAP00000042485; ENSBTAG00000018594.
DR   GeneID; 534550; -.
DR   KEGG; bta:534550; -.
DR   CTD; 55957; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018594; -.
DR   VGNC; VGNC:30892; LIN37.
DR   eggNOG; ENOG502QV4J; Eukaryota.
DR   GeneTree; ENSGT00390000002748; -.
DR   HOGENOM; CLU_090128_0_0_1; -.
DR   InParanoid; Q1RMQ5; -.
DR   OMA; CSNKNQM; -.
DR   OrthoDB; 1278998at2759; -.
DR   TreeFam; TF329230; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000018594; Expressed in laryngeal cartilage and 106 other tissues.
DR   GO; GO:0031523; C:Myb complex; IBA:GO_Central.
DR   GO; GO:0017053; C:transcription repressor complex; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR028226; LIN37.
DR   PANTHER; PTHR31336; PTHR31336; 1.
DR   Pfam; PF15306; LIN37; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Isopeptide bond; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..246
FT                   /note="Protein lin-37 homolog"
FT                   /id="PRO_0000308167"
FT   REGION          36..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
FT   MOD_RES         135
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D8N6"
FT   MOD_RES         138
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
FT   MOD_RES         167
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
FT   MOD_RES         182
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
FT   MOD_RES         202
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
FT   CROSSLNK        5
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
FT   CROSSLNK        7
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
SQ   SEQUENCE   246 AA;  28480 MW;  32D9CD60EA95C424 CRC64;
     MFPVKVKVEK SELEMAKARN QLDAVLQCLL EKSHMDRERL DEEPGKTSLD THNKDCSITA
     TGKRPSARFP HQRRKKRREM DEGLAEGGPQ RSNTYVIKLF DRSVDLAQFS ENTPLYPICR
     AWMRNSPTVR ERERSPSSPL PPLPEDEEGS EVTNSKSRDV YKLPPPTAPG PPGDACRSRI
     PSPLQPETQG TPDDEPSEPE PSPSTLIYRN MQRWKRIRQR WKEASHRNQL RYSESMKILR
     EMYERQ