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LIN37_MOUSE
ID   LIN37_MOUSE             Reviewed;         246 AA.
AC   Q9D8N6;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Protein lin-37 homolog;
DE   AltName: Full=Antolefinin;
DE   AltName: Full=Antolefinine;
GN   Name=Lin37;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ; TISSUE=Brain;
RA   Anton B., Leff P., Matus M., Gonzaga R., Medina R., Calva J.C., Acevedo R.,
RA   Martinez C., Retana I., Saavedra R., Arias A., Zavala E., Pavon L.,
RA   Alagon A.;
RT   "Cloning of a novel 821 bp cDNA from a whole mouse brain with an ORF
RT   encoding a 246 aa protein referred to as antolefinine.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Pancreas;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135; SER-138 AND SER-202, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen, and
RC   Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Component of the DREAM complex (also named LINC complex) at
CC       least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2,
CC       RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent
CC       cells where it represses cell cycle-dependent genes. It dissociates in
CC       S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds
CC       to MYBL2 (By similarity). {ECO:0000250}.
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DR   EMBL; AY428767; AAR06606.1; -; mRNA.
DR   EMBL; AK007858; BAB25310.1; -; mRNA.
DR   CCDS; CCDS21098.1; -.
DR   RefSeq; NP_001277498.1; NM_001290569.1.
DR   RefSeq; NP_083653.1; NM_029377.2.
DR   AlphaFoldDB; Q9D8N6; -.
DR   SMR; Q9D8N6; -.
DR   STRING; 10090.ENSMUSP00000048557; -.
DR   iPTMnet; Q9D8N6; -.
DR   PhosphoSitePlus; Q9D8N6; -.
DR   EPD; Q9D8N6; -.
DR   jPOST; Q9D8N6; -.
DR   MaxQB; Q9D8N6; -.
DR   PaxDb; Q9D8N6; -.
DR   PRIDE; Q9D8N6; -.
DR   ProteomicsDB; 252476; -.
DR   Antibodypedia; 65388; 70 antibodies from 18 providers.
DR   DNASU; 75660; -.
DR   Ensembl; ENSMUST00000043975; ENSMUSP00000048557; ENSMUSG00000036845.
DR   GeneID; 75660; -.
DR   KEGG; mmu:75660; -.
DR   UCSC; uc009gex.1; mouse.
DR   CTD; 55957; -.
DR   MGI; MGI:1922910; Lin37.
DR   VEuPathDB; HostDB:ENSMUSG00000036845; -.
DR   eggNOG; ENOG502QV4J; Eukaryota.
DR   GeneTree; ENSGT00390000002748; -.
DR   InParanoid; Q9D8N6; -.
DR   OMA; CSNKNQM; -.
DR   OrthoDB; 1278998at2759; -.
DR   PhylomeDB; Q9D8N6; -.
DR   TreeFam; TF329230; -.
DR   Reactome; R-MMU-1538133; G0 and Early G1.
DR   BioGRID-ORCS; 75660; 10 hits in 72 CRISPR screens.
DR   ChiTaRS; Lin37; mouse.
DR   PRO; PR:Q9D8N6; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q9D8N6; protein.
DR   Bgee; ENSMUSG00000036845; Expressed in primary oocyte and 65 other tissues.
DR   ExpressionAtlas; Q9D8N6; baseline and differential.
DR   Genevisible; Q9D8N6; MM.
DR   GO; GO:0031523; C:Myb complex; IBA:GO_Central.
DR   GO; GO:0017053; C:transcription repressor complex; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR028226; LIN37.
DR   PANTHER; PTHR31336; PTHR31336; 1.
DR   Pfam; PF15306; LIN37; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Isopeptide bond; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..246
FT                   /note="Protein lin-37 homolog"
FT                   /id="PRO_0000238480"
FT   REGION          39..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
FT   MOD_RES         135
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         138
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         167
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
FT   MOD_RES         182
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
FT   MOD_RES         202
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   CROSSLNK        5
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
FT   CROSSLNK        7
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GY3"
SQ   SEQUENCE   246 AA;  28378 MW;  6FD6104D9945A81D CRC64;
     MFPVKVKVEK SEMEMAKARN QLDAVLQCLL EKSHMDRERL DEEAGKTPLD THNKDCSIAA
     TGKRPSARFP HQRRKKRREM DDGLAEGGPQ RSNTYVIKLF DRSVDLAQFS ENTPLYPICR
     AWMRNSPTVR ERERSPGSPL PPLPEDGEGS EVINSKNRDV YKLPPPTAPG PLGDACRSRI
     PSPLQPETEG TPDDEPSEPE PSPSTLIYRN MQRWKRIRQR WKEASHRNQL RYSESMKILR
     EMYDRQ
 
 
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