LIN52_CAEEL
ID LIN52_CAEEL Reviewed; 161 AA.
AC Q10120; G3MTX2;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein lin-52;
DE AltName: Full=Abnormal cell lineage protein 52;
GN Name=lin-52 {ECO:0000312|WormBase:ZK632.13a};
GN ORFNames=ZK632.13 {ECO:0000312|WormBase:ZK632.13a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND INTERACTION WITH LIN-35.
RX PubMed=12750327; DOI=10.1093/genetics/164.1.135;
RA Thomas J.H., Ceol C.J., Schwartz H.T., Horvitz H.R.;
RT "New genes that interact with lin-35 Rb to negatively regulate the let-60
RT ras pathway in Caenorhabditis elegans.";
RL Genetics 164:135-151(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP FUNCTION, AND MUTAGENESIS OF GLU-36.
RX PubMed=16020796; DOI=10.1534/genetics.104.034173;
RA Davison E.M., Harrison M.M., Walhout A.J., Vidal M., Horvitz H.R.;
RT "lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval
RT induction, encodes a novel nuclear protein that interacts with the LIN-35
RT Rb protein.";
RL Genetics 171:1017-1031(2005).
RN [5]
RP FUNCTION, AND IDENTIFICATION IN THE DRM COMPLEX.
RX PubMed=17075059; DOI=10.1073/pnas.0608461103;
RA Harrison M.M., Ceol C.J., Lu X., Horvitz H.R.;
RT "Some C. elegans class B synthetic multivulva proteins encode a conserved
RT LIN-35 Rb-containing complex distinct from a NuRD-like complex.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:16782-16787(2006).
RN [6]
RP FUNCTION, AND INTERACTION WITH ZTF-11.
RX PubMed=31386623; DOI=10.7554/elife.46703;
RA Lee J., Taylor C.A., Barnes K.M., Shen A., Stewart E.V., Chen A.,
RA Xiang Y.K., Bao Z., Shen K.;
RT "A Myt1 family transcription factor defines neuronal fate by repressing
RT non-neuronal genes.";
RL Elife 8:0-0(2019).
CC -!- FUNCTION: Synthetic multivulva class B (synMuvB) protein
CC (PubMed:16020796, PubMed:17075059). SynMuvB proteins are required to
CC repress the induction of vulval development by Ras signaling and
CC probably act by forming the multiprotein DRM complex that represses
CC transcription (PubMed:17075059). In association with the zinc finger
CC protein ztf-11, negatively regulates the expression of non-neuronal
CC genes during neurogenesis (PubMed:31386623).
CC {ECO:0000269|PubMed:16020796, ECO:0000269|PubMed:17075059,
CC ECO:0000269|PubMed:31386623}.
CC -!- SUBUNIT: Component of the DRM complex, at least composed of lin-9, lin-
CC 35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1 (PubMed:17075059).
CC Interacts with zft-11; the interaction is required to suppress the
CC activation of non-neuronal genes in neurons (PubMed:31386623).
CC {ECO:0000269|PubMed:17075059, ECO:0000269|PubMed:31386623}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:ZK632.13a};
CC IsoId=Q10120-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:ZK632.13b};
CC IsoId=Q10120-2; Sequence=VSP_060463;
CC -!- SIMILARITY: Belongs to the lin-52 family. {ECO:0000305}.
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DR EMBL; AY324109; AAP85302.1; -; mRNA.
DR EMBL; BX284603; CAA80188.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD31173.1; -; Genomic_DNA.
DR PIR; H88566; H88566.
DR RefSeq; NP_001255033.1; NM_001268104.1. [Q10120-1]
DR RefSeq; NP_001255034.1; NM_001268105.1. [Q10120-2]
DR AlphaFoldDB; Q10120; -.
DR SMR; Q10120; -.
DR BioGRID; 41587; 2.
DR ComplexPortal; CPX-1100; DRM complex.
DR DIP; DIP-61305N; -.
DR IntAct; Q10120; 6.
DR STRING; 6239.ZK632.13a; -.
DR EPD; Q10120; -.
DR PaxDb; Q10120; -.
DR PeptideAtlas; Q10120; -.
DR EnsemblMetazoa; ZK632.13a.1; ZK632.13a.1; WBGene00003035. [Q10120-1]
DR EnsemblMetazoa; ZK632.13b.1; ZK632.13b.1; WBGene00003035. [Q10120-2]
DR GeneID; 176393; -.
DR KEGG; cel:CELE_ZK632.13; -.
DR UCSC; ZK632.13.1; c. elegans. [Q10120-1]
DR CTD; 31499; -.
DR WormBase; ZK632.13a; CE01711; WBGene00003035; lin-52. [Q10120-1]
DR WormBase; ZK632.13b; CE46358; WBGene00003035; lin-52. [Q10120-2]
DR eggNOG; KOG4402; Eukaryota.
DR GeneTree; ENSGT00390000008402; -.
DR HOGENOM; CLU_138751_0_0_1; -.
DR InParanoid; Q10120; -.
DR OMA; NTMSHCP; -.
DR OrthoDB; 1493942at2759; -.
DR Reactome; R-CEL-1538133; G0 and Early G1.
DR SignaLink; Q10120; -.
DR PRO; PR:Q10120; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003035; Expressed in embryo and 4 other tissues.
DR GO; GO:0070176; C:DRM complex; IDA:ComplexPortal.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:1903507; P:negative regulation of nucleic acid-templated transcription; IC:ComplexPortal.
DR GO; GO:0009968; P:negative regulation of signal transduction; IMP:WormBase.
DR GO; GO:0040027; P:negative regulation of vulval development; IDA:ComplexPortal.
DR GO; GO:0050767; P:regulation of neurogenesis; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR018737; DREAM_LIN52.
DR PANTHER; PTHR31489; PTHR31489; 1.
DR Pfam; PF10044; LIN52; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..161
FT /note="Protein lin-52"
FT /id="PRO_0000084430"
FT REGION 137..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..40
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_060463"
FT MUTAGEN 36
FT /note="E->K: In n771; temperature-sensitive multivulva
FT phenotype in a lin-8 n111, n2741, n2376, n2378, n2403,
FT n2738, n2731 or n2739 mutant background."
FT /evidence="ECO:0000269|PubMed:16020796"
SQ SEQUENCE 161 AA; 18180 MW; 601BFBDED4FF68FC CRC64;
MSRPLGFIGY EFGDDEMFVQ QMIEKKSNAE QAKMLEQQKK MLECTETMPE ESEPVPMKCL
DFEEAFQSES VSKGYESPYK NISFLKEDAV TVNTMSHCPA DDIAKLIRNI QNSVYTLGIE
EARQCRRGKL LNVLKPTGSA SPRYLQPTPP KNVAEETTGS Q
