LIN52_HUMAN
ID LIN52_HUMAN Reviewed; 116 AA.
AC Q52LA3;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Protein lin-52 homolog;
GN Name=LIN52; Synonyms=C14orf46;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION IN THE DREAM COMPLEX.
RX PubMed=17671431; DOI=10.4161/cc.6.15.4512;
RA Schmit F., Korenjak M., Mannefeld M., Schmitt K., Franke C., von Eyss B.,
RA Gagrica S., Haenel F., Brehm A., Gaubatz S.;
RT "LINC, a human complex that is related to pRB-containing complexes in
RT invertebrates regulates the expression of G2/M genes.";
RL Cell Cycle 6:1903-1913(2007).
RN [3]
RP IDENTIFICATION IN THE DREAM COMPLEX.
RX PubMed=17531812; DOI=10.1016/j.molcel.2007.04.015;
RA Litovchick L., Sadasivam S., Florens L., Zhu X., Swanson S.K.,
RA Velmurugan S., Chen R., Washburn M.P., Liu X.S., DeCaprio J.A.;
RT "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex
RT represses human cell cycle-dependent genes in quiescence.";
RL Mol. Cell 26:539-551(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBUNIT: Component of the DREAM complex (also named LINC complex) at
CC least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2,
CC RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent
CC cells where it represses cell cycle-dependent genes. It dissociates in
CC S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds
CC to MYBL2. {ECO:0000269|PubMed:17531812, ECO:0000269|PubMed:17671431}.
CC -!- INTERACTION:
CC Q52LA3; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-1389456, EBI-6255981;
CC Q52LA3; P43360: MAGEA6; NbExp=3; IntAct=EBI-1389456, EBI-1045155;
CC -!- SIMILARITY: Belongs to the lin-52 family. {ECO:0000305}.
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DR EMBL; BC094003; AAH94003.1; -; mRNA.
DR EMBL; BC094005; AAH94005.1; -; mRNA.
DR RefSeq; NP_001019845.1; NM_001024674.2.
DR PDB; 4YOO; X-ray; 2.40 A; X=15-34.
DR PDB; 6C48; X-ray; 2.32 A; B/E=52-116.
DR PDBsum; 4YOO; -.
DR PDBsum; 6C48; -.
DR AlphaFoldDB; Q52LA3; -.
DR SMR; Q52LA3; -.
DR BioGRID; 124874; 50.
DR CORUM; Q52LA3; -.
DR IntAct; Q52LA3; 10.
DR MINT; Q52LA3; -.
DR STRING; 9606.ENSP00000451812; -.
DR iPTMnet; Q52LA3; -.
DR PhosphoSitePlus; Q52LA3; -.
DR BioMuta; LIN52; -.
DR DMDM; 74754720; -.
DR EPD; Q52LA3; -.
DR jPOST; Q52LA3; -.
DR MassIVE; Q52LA3; -.
DR MaxQB; Q52LA3; -.
DR PaxDb; Q52LA3; -.
DR PeptideAtlas; Q52LA3; -.
DR PRIDE; Q52LA3; -.
DR ProteomicsDB; 62420; -.
DR Antibodypedia; 8; 71 antibodies from 15 providers.
DR DNASU; 91750; -.
DR GeneID; 91750; -.
DR KEGG; hsa:91750; -.
DR UCSC; uc001xpp.3; human.
DR CTD; 91750; -.
DR DisGeNET; 91750; -.
DR GeneCards; LIN52; -.
DR HGNC; HGNC:19856; LIN52.
DR HPA; ENSG00000205659; Low tissue specificity.
DR neXtProt; NX_Q52LA3; -.
DR PharmGKB; PA162394039; -.
DR VEuPathDB; HostDB:ENSG00000205659; -.
DR eggNOG; KOG4402; Eukaryota.
DR HOGENOM; CLU_143062_1_0_1; -.
DR InParanoid; Q52LA3; -.
DR OMA; NANSPPW; -.
DR OrthoDB; 1233803at2759; -.
DR PhylomeDB; Q52LA3; -.
DR TreeFam; TF320091; -.
DR PathwayCommons; Q52LA3; -.
DR Reactome; R-HSA-1362277; Transcription of E2F targets under negative control by DREAM complex.
DR Reactome; R-HSA-1362300; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1.
DR Reactome; R-HSA-1538133; G0 and Early G1.
DR Reactome; R-HSA-156711; Polo-like kinase mediated events.
DR Reactome; R-HSA-69202; Cyclin E associated events during G1/S transition.
DR Reactome; R-HSA-69205; G1/S-Specific Transcription.
DR Reactome; R-HSA-69656; Cyclin A:Cdk2-associated events at S phase entry.
DR SignaLink; Q52LA3; -.
DR SIGNOR; Q52LA3; -.
DR BioGRID-ORCS; 91750; 488 hits in 1082 CRISPR screens.
DR ChiTaRS; LIN52; human.
DR GenomeRNAi; 91750; -.
DR Pharos; Q52LA3; Tbio.
DR PRO; PR:Q52LA3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q52LA3; protein.
DR Bgee; ENSG00000205659; Expressed in secondary oocyte and 198 other tissues.
DR ExpressionAtlas; Q52LA3; baseline and differential.
DR Genevisible; Q52LA3; HS.
DR GO; GO:0070176; C:DRM complex; IEA:InterPro.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR018737; DREAM_LIN52.
DR PANTHER; PTHR31489; PTHR31489; 1.
DR Pfam; PF10044; LIN52; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Phosphoprotein; Reference proteome.
FT CHAIN 1..116
FT /note="Protein lin-52 homolog"
FT /id="PRO_0000252154"
FT MOD_RES 28
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 53
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT HELIX 28..31
FT /evidence="ECO:0007829|PDB:4YOO"
FT HELIX 64..73
FT /evidence="ECO:0007829|PDB:6C48"
FT HELIX 77..106
FT /evidence="ECO:0007829|PDB:6C48"
FT TURN 107..111
FT /evidence="ECO:0007829|PDB:6C48"
SQ SEQUENCE 116 AA; 13001 MW; F9D1F2CA524975D0 CRC64;
MGWKMASPTD GTDLEASLLS FEKLDRASPD LWPEQLPGVA EFAASFKSPI TSSPPKWMAE
IERDDIDMLK ELGSLTTANL MEKVRGLQNL AYQLGLDESR EMTRGKFLNI LEKPKK
