ID   LIN52_ONCMY             Reviewed;         112 AA.
AC   Q6X4M3;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Protein lin-52 homolog;
DE   AltName: Full=12.5 kDa retinal tissue protein;
DE   AltName: Full=Rtp12.5;
GN   Name=lin52;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAP94225.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   TISSUE=Retina {ECO:0000312|EMBL:AAP94225.1};
RX   PubMed=14662307; DOI=10.1016/s1096-4959(03)00262-8;
RA   Dann S.G., Allison W.T., Levin D.B., Hawryshyn C.W.;
RT   "Identification of a unique transcript down-regulated in the retina of
RT   rainbow trout (Oncorhynchus mykiss) at smoltification.";
RL   Comp. Biochem. Physiol. 136B:849-860(2003).
CC   -!- FUNCTION: May be involved in retinal development.
CC       {ECO:0000303|PubMed:14662307}.
CC   -!- SUBUNIT: Component of the DREAM complex. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the brain, liver and retina. Highly
CC       expressed in the retinal ganglion cell and inner nuclear layers at the
CC       parr stage. Expressed at a lower level in inner segments of some
CC       retinal photoreceptors. {ECO:0000269|PubMed:14662307}.
CC   -!- DEVELOPMENTAL STAGE: Down-regulated in the retina at smoltification,
CC       the metamorphic transformation from a parr to a molt.
CC       {ECO:0000269|PubMed:14662307}.
CC   -!- SIMILARITY: Belongs to the lin-52 family. {ECO:0000305}.
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DR   EMBL; AY255832; AAP94225.1; -; mRNA.
DR   RefSeq; NP_001117925.1; NM_001124453.1.
DR   AlphaFoldDB; Q6X4M3; -.
DR   SMR; Q6X4M3; -.
DR   GeneID; 100136175; -.
DR   KEGG; omy:100136175; -.
DR   OrthoDB; 1513733at2759; -.
DR   GO; GO:0070176; C:DRM complex; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR018737; DREAM_LIN52.
DR   PANTHER; PTHR31489; PTHR31489; 1.
DR   Pfam; PF10044; LIN52; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein.
FT   CHAIN           1..112
FT                   /note="Protein lin-52 homolog"
FT                   /id="PRO_0000097519"
SQ   SEQUENCE   112 AA;  12485 MW;  4DAA1BB1BA54D026 CRC64;
     MASPNGGDDF ESSLLSFEKL DRASPDLWPE QLPGVADFAA SCKNPITNSP PKWMAELESE
     DIEMLKKLGS LTTANLMEKV KGLQNLAYQL GLEESREMTR GKFLNILERP KK