LIN53_CAEBR
ID LIN53_CAEBR Reviewed; 416 AA.
AC Q61Y48; A8WWI6;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Probable histone-binding protein lin-53;
GN Name=lin-53 {ECO:0000250|UniProtKB:P90916}; ORFNames=CBG03710;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Core histone-binding subunit that may target chromatin
CC assembly factors, chromatin remodeling factors and histone deacetylases
CC to their histone substrates in a manner that is regulated by
CC nucleosomal DNA. Required for hcp-3 and his-1 stabilization,
CC localization of hcp-3 to centromeres and for proper chromosome
CC segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB
CC proteins are required to repress the induction of vulval development by
CC Ras signaling and probably act by forming the multiprotein DRM complex
CC that represses transcription. {ECO:0000250|UniProtKB:P90916,
CC ECO:0000250|UniProtKB:Q24572}.
CC -!- SUBUNIT: Binds directly to helix 1 of the histone fold of histone H4, a
CC region that is not accessible when H4 is in chromatin. Probable
CC component of a NuRD-like complex, composed of at least lin-53 and hda-
CC 1. Interacts with lin-35. Interacts with hda-1; the interaction is
CC direct. Component of the DRM complex, at least composed of lin-9, lin-
CC 35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1. Interacts with
CC hcp-3. {ECO:0000250|UniProtKB:P90916, ECO:0000250|UniProtKB:Q24572}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P90916}.
CC Chromosome, centromere {ECO:0000250|UniProtKB:P90916}. Note=Localizes
CC to centromeres during metaphase. Requires hcp-3 and knl-2 for nuclear
CC and centromere localization. {ECO:0000250|UniProtKB:P90916}.
CC -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC {ECO:0000255}.
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DR EMBL; HE600990; CAP24558.3; -; Genomic_DNA.
DR AlphaFoldDB; Q61Y48; -.
DR SMR; Q61Y48; -.
DR STRING; 6238.CBG03710; -.
DR EnsemblMetazoa; CBG03710.1; CBG03710.1; WBGene00026512.
DR WormBase; CBG03710; CBP37586; WBGene00026512; Cbr-lin-53.
DR eggNOG; KOG0264; Eukaryota.
DR HOGENOM; CLU_020445_3_1_1; -.
DR InParanoid; Q61Y48; -.
DR OMA; PITDFNW; -.
DR Proteomes; UP000008549; Chromosome I.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0070176; C:DRM complex; IEA:EnsemblMetazoa.
DR GO; GO:0035098; C:ESC/E(Z) complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0016581; C:NuRD complex; IBA:GO_Central.
DR GO; GO:0017053; C:transcription repressor complex; ISS:UniProtKB.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; ISS:UniProtKB.
DR GO; GO:0001708; P:cell fate specification; IEA:EnsemblMetazoa.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0040035; P:hermaphrodite genitalia development; ISS:UniProtKB.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0034514; P:mitochondrial unfolded protein response; IEA:EnsemblMetazoa.
DR GO; GO:0040027; P:negative regulation of vulval development; IEA:EnsemblMetazoa.
DR GO; GO:0045138; P:nematode male tail tip morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Centromere; Chromatin regulator; Chromosome; Developmental protein;
KW Nucleus; Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..416
FT /note="Probable histone-binding protein lin-53"
FT /id="PRO_0000312665"
FT REPEAT 118..158
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 170..210
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 220..260
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 263..303
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 307..347
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 364..404
FT /note="WD 6"
FT /evidence="ECO:0000255"
SQ SEQUENCE 416 AA; 46919 MW; D3C47B35D762689D CRC64;
MATIEDGTSE DRVANDEYKI WKKNTPFLYD LVMTHALEWP SLSVQWLPEI EKESSDHTVH
RLILGTHTSD EQNHLLISKI CMPTDEAQFD ASRYDTERGE FGGFGAVNGK VEPDIRINHE
GEVNRARYMP QKPTIIATKS PSADVYIFDY TKYPSVPKDN TFNPLLKLKG HTKEGYGLSW
NPNKEGLILS ASDDQTVCHW DINGNAGANG ELKAREIFKG HESVVEDVAW HVLHDGVFGS
VGDDKKLLIW DLRTNVPGHA IDAHSAEVNC LAFNPYSEFI LATGSADKTV ALWDLRNLRL
KLHSFESHRD EIFQVQWSPH NETILASSGT DKRLHVWDLS KIGEDQTAED AEDGPPELLF
IHGGHTAKIS DFSWNPNEPW VVCSVSEDNI LQVWQMADNI YNDVEDETPA DMVERS
