ID   LIN56_CAEEL             Reviewed;         322 AA.
AC   Q09377;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Protein lin-56;
DE   AltName: Full=Abnormal cell lineage protein 56;
GN   Name=lin-56; ORFNames=ZK673.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND DISRUPTION PHENOTYPE.
RX   PubMed=21196525; DOI=10.1534/genetics.110.124487;
RA   Davison E.M., Saffer A.M., Huang L.S., DeModena J., Sternberg P.W.,
RA   Horvitz H.R.;
RT   "The LIN-15A and LIN-56 transcriptional regulators interact to negatively
RT   regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate
RT   determination.";
RL   Genetics 187:803-815(2011).
CC   -!- FUNCTION: Required for translation, stability and/or localization of
CC       lin-15a. {ECO:0000269|PubMed:21196525}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21196525}.
CC   -!- TISSUE SPECIFICITY: Widely expressed throughout embryonic development.
CC       Expressed in the six multipotent ventral ectodermal blast cells, P3.p-
CC       P8.p, which generate the vulva and in their descendants throughout
CC       vulval development. {ECO:0000269|PubMed:21196525}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from the early one-cell or late two-cell
CC       stage and continues throughout embryonic and larval development and in
CC       adulthood. {ECO:0000269|PubMed:21196525}.
CC   -!- DISRUPTION PHENOTYPE: Greatly reduced nuclear accumulation of lin-15a
CC       protein but no effect on mRNA levels. {ECO:0000269|PubMed:21196525}.
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DR   EMBL; Z48585; CAA88485.1; -; Genomic_DNA.
DR   PIR; T27966; T27966.
DR   RefSeq; NP_496246.1; NM_063845.3.
DR   AlphaFoldDB; Q09377; -.
DR   BioGRID; 39927; 4.
DR   IntAct; Q09377; 4.
DR   STRING; 6239.ZK673.3; -.
DR   EPD; Q09377; -.
DR   PaxDb; Q09377; -.
DR   PeptideAtlas; Q09377; -.
DR   EnsemblMetazoa; ZK673.3.1; ZK673.3.1; WBGene00003038.
DR   GeneID; 174609; -.
DR   KEGG; cel:CELE_ZK673.3; -.
DR   UCSC; ZK673.3; c. elegans.
DR   CTD; 174609; -.
DR   WormBase; ZK673.3; CE16743; WBGene00003038; lin-56.
DR   eggNOG; ENOG502TK40; Eukaryota.
DR   HOGENOM; CLU_863906_0_0_1; -.
DR   InParanoid; Q09377; -.
DR   SignaLink; Q09377; -.
DR   PRO; PR:Q09377; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00003038; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR   GO; GO:0034504; P:protein localization to nucleus; IMP:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; IMP:UniProtKB.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0040025; P:vulval development; IEP:UniProtKB.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Translation regulation.
FT   CHAIN           1..322
FT                   /note="Protein lin-56"
FT                   /id="PRO_0000065537"
FT   REGION          264..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..309
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   322 AA;  36927 MW;  BC4B948D0416F2DA CRC64;
     MDHHAMYRTA EFNKTTVRLL AEFIEKTGQN ATIVNMDSFL EFFAYLNPTA PIPTVPEIEK
     QLLLKSPIRC IVCGMETESD SAVTLSIDNA SIILTATVIG YCRDPSDAVN QIRKESLRAC
     TKHFNSIFHV IFEGLQIENT YCAHHAKYSL ANRWCKVYTM IRSSLGEQFT KFDVRNFKSI
     LQSFLDTFGE IDDDKKDKES SHFDECFEEM DSENVEIKME SPQEEAAEKS KFSENLVEVK
     LEPIETHELD KTISDFSSSD IIDSSQKLQQ NGFPEKVEQM DKYSNKLKDE ASDKKYEKPG
     KKDYVEEEGY WAPITDSEDD EA