LIN7A_BOVIN
ID LIN7A_BOVIN Reviewed; 233 AA.
AC Q32LM6;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein lin-7 homolog A;
DE Short=Lin-7A;
GN Name=LIN7A;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in establishing and maintaining the asymmetric
CC distribution of channels and receptors at the plasma membrane of
CC polarized cells. Forms membrane-associated multiprotein complexes that
CC may regulate delivery and recycling of proteins to the correct membrane
CC domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or
CC LIN7C), CASK and APBA1 associates with the motor protein KIF17 to
CC transport vesicles containing N-methyl-D-aspartate (NMDA) receptor
CC subunit NR2B along microtubules (By similarity). This complex may have
CC the potential to couple synaptic vesicle exocytosis to cell adhesion in
CC brain. Ensures the proper localization of GRIN2B (subunit 2B of the
CC NMDA receptor) to neuronal postsynaptic density and may function in
CC localizing synaptic vesicles at synapses where it is recruited by beta-
CC catenin and cadherin. Required to localize Kir2 channels, GABA
CC transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the
CC basolateral membrane of epithelial cells (By similarity). {ECO:0000250,
CC ECO:0000250|UniProtKB:Q8JZS0}.
CC -!- SUBUNIT: Forms a complex with CASK and CASKIN1. Component of the brain-
CC specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed
CC of at least APBA1, CASK, and LIN7, which associates with the motor
CC protein KIF17 to transport vesicles along microtubules (By similarity).
CC Can also interact with other modular proteins containing protein-
CC protein interaction domains like PALS1, PALS2, MPP7, DLG1, DLG2 and
CC DLG3 through its L27 domain. Interacts with DLG4, GRIN2B and MARCHF11
CC as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3
CC and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The
CC association of LIN7A with cadherin and beta-catenin is calcium-
CC dependent, occurs at synaptic junctions and requires the actin
CC cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ
CC and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4.
CC Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or
CC LIN7C) (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8JZS0}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8JZS0};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q8JZS0}. Basolateral
CC cell membrane {ECO:0000250|UniProtKB:Q8JZS0}; Peripheral membrane
CC protein {ECO:0000250|UniProtKB:Q8JZS0}. Cell junction
CC {ECO:0000250|UniProtKB:Q8JZS0}. Postsynaptic density membrane
CC {ECO:0000250|UniProtKB:Q8JZS0}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q8JZS0}. Cell junction, tight junction
CC {ECO:0000250|UniProtKB:Q8JZS0}. Note=Mainly basolateral in renal
CC epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0}.
CC -!- DOMAIN: The L27 domain mediates interaction with CASK and is involved
CC in the formation of multimeric complexes and the association of LIN7 to
CC membranes. {ECO:0000250}.
CC -!- DOMAIN: The PDZ domain regulates endocytosis and recycling of the
CC receptor at the membrane. {ECO:0000250}.
CC -!- DOMAIN: The kinase interacting site is required for proper delivery of
CC ERBB2 to the basolateral membrane. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lin-7 family. {ECO:0000305}.
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DR EMBL; BC109509; AAI09510.1; -; mRNA.
DR RefSeq; NP_001073070.1; NM_001079602.2.
DR AlphaFoldDB; Q32LM6; -.
DR SMR; Q32LM6; -.
DR STRING; 9913.ENSBTAP00000015103; -.
DR PaxDb; Q32LM6; -.
DR Ensembl; ENSBTAT00000015103; ENSBTAP00000015103; ENSBTAG00000011367.
DR Ensembl; ENSBTAT00000070192; ENSBTAP00000066458; ENSBTAG00000011367.
DR GeneID; 528379; -.
DR KEGG; bta:528379; -.
DR CTD; 8825; -.
DR VEuPathDB; HostDB:ENSBTAG00000011367; -.
DR VGNC; VGNC:30895; LIN7A.
DR eggNOG; KOG3550; Eukaryota.
DR GeneTree; ENSGT00940000153222; -.
DR HOGENOM; CLU_097962_0_0_1; -.
DR InParanoid; Q32LM6; -.
DR OMA; AIRERKH; -.
DR OrthoDB; 1335138at2759; -.
DR TreeFam; TF316850; -.
DR Reactome; R-BTA-212676; Dopamine Neurotransmitter Release Cycle.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000011367; Expressed in semen and 91 other tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0097025; C:MPP7-DLG1-LIN7 complex; IBA:GO_Central.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0097016; F:L27 domain binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0048839; P:inner ear development; IEA:Ensembl.
DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR GO; GO:1903361; P:protein localization to basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0048489; P:synaptic vesicle transport; IEA:Ensembl.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR017365; LIN7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038039; Lin-7_homologue; 1.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF101288; SSF101288; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Exocytosis; Membrane;
KW Postsynaptic cell membrane; Protein transport; Reference proteome; Synapse;
KW Tight junction; Transport.
FT CHAIN 1..233
FT /note="Protein lin-7 homolog A"
FT /id="PRO_0000238667"
FT DOMAIN 25..80
FT /note="L27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00365"
FT DOMAIN 108..190
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
SQ SEQUENCE 233 AA; 25997 MW; D8D05EF16A93BE7B CRC64;
MLKPSVTSAP TADMATLTVV QPLTLDRDVA RAIELLEKLQ ESGEVPVHKL QSLKKVLQSE
FCTAIREVYQ YMHETITVNG CPEFRARATA KATVAAFAAS EGHSHPRVVE LPKTDEGLGF
NVMGGKEQNS PIYISRIIPG GVAERHGGLK RGDQLLSVNG VSVEGEHHEK AVELLKAAKD
SVKLVVRYTP KVLEEMEARF EKLRTARRRQ QQQLLIQQQQ QQQQQQTQQN HMS
