LIN7B_BOVIN
ID LIN7B_BOVIN Reviewed; 201 AA.
AC Q2KIB6;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein lin-7 homolog B;
DE Short=Lin-7B;
GN Name=LIN7B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in establishing and maintaining the asymmetric
CC distribution of channels and receptors at the plasma membrane of
CC polarized cells. Forms membrane-associated multiprotein complexes that
CC may regulate delivery and recycling of proteins to the correct membrane
CC domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or
CC LIN7C), CASK and APBA1 associates with the motor protein KIF17 to
CC transport vesicles containing N-methyl-D-aspartate (NMDA) receptor
CC subunit NR2B along microtubules (By similarity). This complex may have
CC the potential to couple synaptic vesicle exocytosis to cell adhesion in
CC brain. Ensures the proper localization of GRIN2B (subunit 2B of the
CC NMDA receptor) to neuronal postsynaptic density and may function in
CC localizing synaptic vesicles at synapses where it is recruited by beta-
CC catenin and cadherin. Required to localize Kir2 channels, GABA
CC transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the
CC basolateral membrane of epithelial cells. May increase the amplitude of
CC ASIC3 acid-evoked currents by stabilizing the channel at the cell
CC surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88951}.
CC -!- SUBUNIT: Forms a complex with CASK and CASKIN1 (By similarity).
CC Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-
CC LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which
CC associates with the motor protein KIF17 to transport vesicles along
CC microtubules (By similarity). Forms a heterotrimeric complex composed
CC of MMP5, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts
CC with the L27 domain of PATJ and the C-terminal L27 domain of PALS1
CC interacts with the L27 domain of LIN7B (By similarity). Forms a
CC heterotrimeric complex with DLG1 and CASK via their L27 domains (By
CC similarity). Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1,
CC the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and
CC SLC6A12/BGT-1 via its PDZ domain (By similarity). The association of
CC LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at
CC synaptic junctions and requires the actin cytoskeleton. Interacts with
CC EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains (By
CC similarity). Interacts with ASIC3 (By similarity). Interacts with TOPK.
CC Interacts with RTKN (By similarity). Associates with KIF17 via APBA1
CC (By similarity). Interacts with APBA1 (By similarity). Interacts with
CC MPP7 (By similarity). Interacts with DLG2 (By similarity). Interacts
CC with DLG3 (By similarity). {ECO:0000250|UniProtKB:O88951,
CC ECO:0000250|UniProtKB:Q9HAP6, ECO:0000250|UniProtKB:Q9Z252}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O88951};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Basolateral
CC cell membrane {ECO:0000250|UniProtKB:O88951}; Peripheral membrane
CC protein {ECO:0000250|UniProtKB:O88951}. Cell junction
CC {ECO:0000250|UniProtKB:O88951}. Postsynaptic density membrane
CC {ECO:0000250|UniProtKB:O88951}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O88951}. Cell junction, tight junction
CC {ECO:0000250|UniProtKB:O88951}. Note=Mainly basolateral in renal
CC epithelial cells. {ECO:0000250|UniProtKB:O88951}.
CC -!- DOMAIN: The kinase interacting site is required for proper delivery of
CC ERBB2 to the basolateral membrane. {ECO:0000250}.
CC -!- DOMAIN: The PDZ domain regulates endocytosis and recycling of the
CC receptor at the membrane. {ECO:0000250}.
CC -!- DOMAIN: The L27 domain mediates interaction with CASK and is involved
CC in the formation of multimeric complexes and the association of LIN7 to
CC membranes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lin-7 family. {ECO:0000305}.
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DR EMBL; BC112698; AAI12699.1; -; mRNA.
DR RefSeq; NP_001040042.1; NM_001046577.2.
DR AlphaFoldDB; Q2KIB6; -.
DR SMR; Q2KIB6; -.
DR STRING; 9913.ENSBTAP00000040675; -.
DR PaxDb; Q2KIB6; -.
DR PRIDE; Q2KIB6; -.
DR Ensembl; ENSBTAT00000043080; ENSBTAP00000040675; ENSBTAG00000023415.
DR GeneID; 616283; -.
DR KEGG; bta:616283; -.
DR CTD; 64130; -.
DR VEuPathDB; HostDB:ENSBTAG00000023415; -.
DR VGNC; VGNC:30896; LIN7B.
DR eggNOG; KOG3550; Eukaryota.
DR GeneTree; ENSGT00940000153222; -.
DR HOGENOM; CLU_097962_0_0_1; -.
DR InParanoid; Q2KIB6; -.
DR OMA; YYHPGKE; -.
DR OrthoDB; 1335138at2759; -.
DR TreeFam; TF316850; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000023415; Expressed in retina and 103 other tissues.
DR ExpressionAtlas; Q2KIB6; baseline and differential.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0097025; C:MPP7-DLG1-LIN7 complex; IBA:GO_Central.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0097016; F:L27 domain binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR GO; GO:1903361; P:protein localization to basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR017365; LIN7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038039; Lin-7_homologue; 1.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF101288; SSF101288; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Exocytosis; Membrane;
KW Postsynaptic cell membrane; Protein transport; Reference proteome; Synapse;
KW Tight junction; Transport.
FT CHAIN 1..201
FT /note="Protein lin-7 homolog B"
FT /id="PRO_0000286351"
FT DOMAIN 10..65
FT /note="L27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00365"
FT DOMAIN 93..175
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT MOTIF 1..13
FT /note="Kinase interacting site"
FT /evidence="ECO:0000250"
SQ SEQUENCE 201 AA; 22280 MW; EEF4BC2CEBF797CA CRC64;
MAALVEPLGL EREVSRAVEL LERLQRSGEL PPQKLQALQR VLQSRFCSAI REVYEQLYDT
LDITGSAEIR AHATAKATVA AFTASEGHAH PRVVELPKTD EGLGFNIMGG KEQNSPIYIS
RVIPGGVADR HGGLKRGDQL LSVNGVSVEG EQHEKAVELL KAAQGSVKLV VRYTPRVLEE
MEARFEKMRS ARRRQQHQSY S
