LIN7C_CHICK
ID LIN7C_CHICK Reviewed; 197 AA.
AC Q5F425;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein lin-7 homolog C;
DE Short=Lin-7C;
GN Name=LIN7C; ORFNames=RCJMB04_3l24;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Plays a role in establishing and maintaining the asymmetric
CC distribution of channels and receptors at the plasma membrane of
CC polarized cells. Forms membrane-associated multiprotein complexes that
CC may regulate delivery and recycling of proteins to the correct membrane
CC domains (By similarity). The tripartite complex composed of LIN7
CC (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor
CC protein KIF17 to transport vesicles containing N-methyl-D-aspartate
CC (NMDA) receptor subunit NR2B along microtubules (By similarity).
CC {ECO:0000250, ECO:0000250|UniProtKB:O88952}.
CC -!- SUBUNIT: Component of the brain-specific heterotrimeric complex (LIN-
CC 10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7,
CC which associates with the motor protein KIF17 to transport vesicles
CC along microtubules. {ECO:0000250|UniProtKB:O88952}.
CC -!- INTERACTION:
CC Q5F425; Q8AYS8: KCNMA1; NbExp=3; IntAct=EBI-1636456, EBI-1635766;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}. Cell junction {ECO:0000250}.
CC -!- DOMAIN: The L27 domain mediates interaction with CASK and is involved
CC in the formation of multimeric complexes and the association of LIN7 to
CC membranes. {ECO:0000250}.
CC -!- DOMAIN: The PDZ domain regulates endocytosis and recycling of the
CC receptor at the membrane. {ECO:0000250}.
CC -!- DOMAIN: The kinase interacting site is required for proper delivery of
CC ERBB2 to the basolateral membrane. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lin-7 family. {ECO:0000305}.
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DR EMBL; AJ851475; CAH65109.1; -; mRNA.
DR RefSeq; NP_001026238.1; NM_001031067.1.
DR RefSeq; XP_015141655.1; XM_015286169.1.
DR AlphaFoldDB; Q5F425; -.
DR SMR; Q5F425; -.
DR BioGRID; 682402; 1.
DR IntAct; Q5F425; 1.
DR STRING; 9031.ENSGALP00000039371; -.
DR PaxDb; Q5F425; -.
DR PRIDE; Q5F425; -.
DR Ensembl; ENSGALT00000040172; ENSGALP00000039371; ENSGALG00000012170.
DR GeneID; 421608; -.
DR KEGG; gga:421608; -.
DR CTD; 55327; -.
DR VEuPathDB; HostDB:geneid_421608; -.
DR eggNOG; KOG3550; Eukaryota.
DR GeneTree; ENSGT00940000153222; -.
DR HOGENOM; CLU_097962_0_0_1; -.
DR InParanoid; Q5F425; -.
DR OMA; MENRFER; -.
DR OrthoDB; 1335138at2759; -.
DR PhylomeDB; Q5F425; -.
DR TreeFam; TF316850; -.
DR Reactome; R-GGA-212676; Dopamine Neurotransmitter Release Cycle.
DR PRO; PR:Q5F425; -.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000012170; Expressed in colon and 13 other tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0097025; C:MPP7-DLG1-LIN7 complex; IBA:GO_Central.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0097016; F:L27 domain binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR GO; GO:1903361; P:protein localization to basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR017365; LIN7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038039; Lin-7_homologue; 1.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF101288; SSF101288; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW Cell junction; Cell membrane; Exocytosis; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..197
FT /note="Protein lin-7 homolog C"
FT /id="PRO_0000238669"
FT DOMAIN 10..65
FT /note="L27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00365"
FT DOMAIN 93..175
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT MOTIF 1..13
FT /note="Kinase interacting site"
FT /evidence="ECO:0000250"
SQ SEQUENCE 197 AA; 21847 MW; 61F0FBFA3BD24F45 CRC64;
MAALGEPVRL ERDICRAIEL LEKLQRSGEV PPQKLQALQR VLQSEFCNAV REVYEHVYET
VDISSSPEVR ANATAKATVA AFAASEGHSH PRVVELPKTE EGLGFNIMGG KEQNSPIYIS
RIIPGGIADR HGGLKRGDQL LSVNGVSVEG EHHEKAVELL KAAQGKVKLV VRYTPKVLEE
MESRFEKMRS AKRRQQN
