LIN9_CAEEL
ID LIN9_CAEEL Reviewed; 644 AA.
AC P30630; Q9NB37; Q9NB38;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2003, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein lin-9;
DE AltName: Full=Abnormal cell lineage protein 9;
GN Name=lin-9 {ECO:0000312|WormBase:ZK637.7b};
GN ORFNames=ZK637.7 {ECO:0000312|WormBase:ZK637.7b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION, AND MUTAGENESIS OF
RP GLY-341.
RC STRAIN=Bristol N2;
RX PubMed=10974557; DOI=10.1016/s0378-1119(00)00296-1;
RA Beitel G.J., Lambie E.J., Horvitz H.R.;
RT "The C. elegans gene lin-9, which acts in an Rb-related pathway, is
RT required for gonadal sheath cell development and encodes a novel protein.";
RL Gene 254:253-263(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=1538779; DOI=10.1038/356037a0;
RA Sulston J., Du Z., Thomas K., Wilson R., Hillier L., Staden R.,
RA Halloran N., Green P., Thierry-Mieg J., Qiu L., Dear S., Coulson A.,
RA Craxton M., Durbin R., Berks M., Metzstein M., Hawkins T., Ainscough R.,
RA Waterston R.;
RT "The C. elegans genome sequencing project: a beginning.";
RL Nature 356:37-41(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP FUNCTION, AND MUTAGENESIS OF GLY-341.
RX PubMed=16678779; DOI=10.1016/j.devcel.2006.04.001;
RA Cui M., Chen J., Myers T.R., Hwang B.J., Sternberg P.W., Greenwald I.,
RA Han M.;
RT "SynMuv genes redundantly inhibit lin-3/EGF expression to prevent
RT inappropriate vulval induction in C. elegans.";
RL Dev. Cell 10:667-672(2006).
RN [5]
RP FUNCTION, IDENTIFICATION IN THE DRM COMPLEX, AND DISRUPTION PHENOTYPE.
RX PubMed=17075059; DOI=10.1073/pnas.0608461103;
RA Harrison M.M., Ceol C.J., Lu X., Horvitz H.R.;
RT "Some C. elegans class B synthetic multivulva proteins encode a conserved
RT LIN-35 Rb-containing complex distinct from a NuRD-like complex.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:16782-16787(2006).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=17237514; DOI=10.1534/genetics.106.068148;
RA Reddien P.W., Andersen E.C., Huang M.C., Horvitz H.R.;
RT "DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein
RT to promote programmed cell death in Caenorhabditis elegans.";
RL Genetics 175:1719-1733(2007).
RN [7]
RP DISRUPTION PHENOTYPE.
RX PubMed=27650246; DOI=10.1038/srep33884;
RA Al-Amin M., Min H., Shim Y.H., Kawasaki I.;
RT "Somatically expressed germ-granule components, PGL-1 and PGL-3, repress
RT programmed cell death in C. elegans.";
RL Sci. Rep. 6:33884-33884(2016).
RN [8]
RP FUNCTION, AND INTERACTION WITH ZTF-11.
RX PubMed=31386623; DOI=10.7554/elife.46703;
RA Lee J., Taylor C.A., Barnes K.M., Shen A., Stewart E.V., Chen A.,
RA Xiang Y.K., Bao Z., Shen K.;
RT "A Myt1 family transcription factor defines neuronal fate by repressing
RT non-neuronal genes.";
RL Elife 8:0-0(2019).
CC -!- FUNCTION: Synthetic multivulva class B (synMuvB) protein
CC (PubMed:16678779, PubMed:17075059). SynMuvB proteins are required to
CC repress the induction of vulval development by Ras signaling and
CC probably act by forming the multiprotein DRM complex that represses
CC transcription (PubMed:17075059). Required for the development of sheath
CC cells in the hermaphrodite gonad and for the development of the male
CC spicule, rays and gonad (PubMed:10974557). In association with the zinc
CC finger protein ztf-11, negatively regulates the expression of non-
CC neuronal genes during neurogenesis (PubMed:31386623).
CC {ECO:0000269|PubMed:10974557, ECO:0000269|PubMed:16678779,
CC ECO:0000269|PubMed:17075059, ECO:0000269|PubMed:31386623}.
CC -!- SUBUNIT: Component of the DRM complex, at least composed of lin-9, lin-
CC 35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1 (PubMed:17075059).
CC Interacts with zft-11; the interaction is required to suppress the
CC activation of non-neuronal genes in neurons (PubMed:31386623).
CC {ECO:0000269|PubMed:17075059, ECO:0000269|PubMed:31386623}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b; Synonyms=LIN-9L;
CC IsoId=P30630-1; Sequence=Displayed;
CC Name=a; Synonyms=LIN-9S;
CC IsoId=P30630-2; Sequence=VSP_007013;
CC -!- DISRUPTION PHENOTYPE: Decreased protein levels of DRM complex
CC components including lin-37, lin-52 and lin-54 (PubMed:17075059).
CC Double knockout with the programmed cell death regulator mcd-1 results
CC in 100% lethality during the L1 stage of larval development
CC (PubMed:17237514). RNAi-mediated knockdown in a ced-1 mutant background
CC results in reduced somatic cell apoptosis (PubMed:27650246).
CC {ECO:0000269|PubMed:17075059, ECO:0000269|PubMed:17237514,
CC ECO:0000269|PubMed:27650246}.
CC -!- SIMILARITY: Belongs to the lin-9 family. {ECO:0000305}.
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DR EMBL; AF269693; AAF76192.1; -; mRNA.
DR EMBL; AF269694; AAF76193.1; -; mRNA.
DR EMBL; BX284603; CAA77454.2; -; Genomic_DNA.
DR EMBL; BX284603; CAC42391.1; -; Genomic_DNA.
DR PIR; A88542; A88542.
DR PIR; S15794; S15794.
DR RefSeq; NP_001023015.1; NM_001027844.2. [P30630-2]
DR RefSeq; NP_001023016.1; NM_001027845.2. [P30630-1]
DR AlphaFoldDB; P30630; -.
DR SMR; P30630; -.
DR BioGRID; 41457; 5.
DR ComplexPortal; CPX-1100; DRM complex.
DR DIP; DIP-61304N; -.
DR IntAct; P30630; 5.
DR STRING; 6239.ZK637.7b; -.
DR iPTMnet; P30630; -.
DR EPD; P30630; -.
DR PaxDb; P30630; -.
DR PeptideAtlas; P30630; -.
DR PRIDE; P30630; -.
DR EnsemblMetazoa; ZK637.7a.1; ZK637.7a.1; WBGene00002998. [P30630-2]
DR EnsemblMetazoa; ZK637.7b.1; ZK637.7b.1; WBGene00002998. [P30630-1]
DR GeneID; 176256; -.
DR KEGG; cel:CELE_ZK637.7; -.
DR UCSC; ZK637.7b.2; c. elegans. [P30630-1]
DR CTD; 176256; -.
DR WormBase; ZK637.7a; CE28194; WBGene00002998; lin-9. [P30630-2]
DR WormBase; ZK637.7b; CE28195; WBGene00002998; lin-9. [P30630-1]
DR eggNOG; KOG1019; Eukaryota.
DR GeneTree; ENSGT00390000003188; -.
DR InParanoid; P30630; -.
DR OMA; RYKKARQ; -.
DR OrthoDB; 622946at2759; -.
DR PhylomeDB; P30630; -.
DR Reactome; R-CEL-1538133; G0 and Early G1.
DR PRO; PR:P30630; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00002998; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0070176; C:DRM complex; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0008406; P:gonad development; IMP:WormBase.
DR GO; GO:0008584; P:male gonad development; IMP:WormBase.
DR GO; GO:1903507; P:negative regulation of nucleic acid-templated transcription; IC:ComplexPortal.
DR GO; GO:0040027; P:negative regulation of vulval development; IDA:ComplexPortal.
DR GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0050767; P:regulation of neurogenesis; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0000003; P:reproduction; IMP:WormBase.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR033471; DIRP.
DR InterPro; IPR010561; LIN-9/ALY1.
DR InterPro; IPR045831; LIN9_C.
DR PANTHER; PTHR21689; PTHR21689; 1.
DR Pfam; PF06584; DIRP; 1.
DR Pfam; PF19438; LIN9_C; 1.
DR SMART; SM01135; DIRP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Nucleus; Reference proteome;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..644
FT /note="Protein lin-9"
FT /id="PRO_0000084433"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 104..105
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000303|PubMed:10974557"
FT /id="VSP_007013"
FT MUTAGEN 341
FT /note="G->E: In n112; weak synthetic multivulva phenotype.
FT Temperature-sensitive multivulva phenotype in a lin-8 n111
FT mutant background."
FT /evidence="ECO:0000269|PubMed:10974557,
FT ECO:0000269|PubMed:16678779"
SQ SEQUENCE 644 AA; 73333 MW; C224EB2AE6FEAF92 CRC64;
MSSAVRSPRK KAASDTSDPD RTSSPYSLRE TSKVPSRYRN EELYLSPSRS IKRTGSPKKS
PAKRLNGGRD SPSVNSLTRN SSLTMLAKAA LDYESSSCAL EYIFQPKEER RPPRRALALS
PPPAPSNDLL AKDLEMIEMH QNLVAGLDDL DNPANMTNEA VEHRDTQSFF NMFSTDQERS
AMMKQFKTYK NQTSEDVSTF MRANIKKLYN LLRYKKARQW VMCEFFYSAI DEQIFKEENE
FATIIRESFP NLKNWNLTRI EWRSIRKLLG KPRRCSKVFF EEERMYLEEK RMKIRSVYEG
SYLNDPSIDL KDLPAKLPRP MVVGNRVFAR IRNPYDGIYS GIIDAVIPKG FRIIFDKPDI
PPTLVSDTEI LLDGKLDLLS IAYFIEQANS KLPSGVRPFV AAVRDSSHPH LVRDVLVSRK
IERSGGPLMG PNDERLNGKN AEMVGNFPLK FLVNLVKLTK LIDIKKGLIR QLNELNADAE
IQNMTSDKYS KAFQEKYAKT IIDLEHVNQN IDINMNGIQD HHMYFSSNDI STSNMKPEAV
RQMCSQQAGR FVEHCNQGLN VENVHALTLI QSLTAVLLQV RTMGTQKISA VDLQSLGDAI
SEIRTAIHPR NVAFFQDYVE VHMKQFHTIM LESGALAGTV SNRK